Slc22a7 solute carrier family 22 (organic anion transporter), member 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc22a7provided by MGI
Official Full Name: solute carrier family 22 (organic anion transporter), member 7provided by MGI
Primary source: MGI:MGI:1859559
See related: Ensembl:ENSMUSG00000067144 AllianceGenome:MGI:1859559
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NLT; OAT2
Summary: Enables alpha-ketoglutarate transmembrane transporter activity and prostaglandin transmembrane transporter activity. Involved in alpha-ketoglutarate transport; prostaglandin transport; and response to stilbenoid. Located in apical plasma membrane. Is expressed in metanephros. Orthologous to human SLC22A7 (solute carrier family 22 member 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward kidney adult (RPKM 85.4) See more
Orthologs: human all
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Genomic context

Location:: 17 C; 17 22.9 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (46743111..46749403, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (46432185..46438477, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

propionate (3-carbon SCFA) was transported by mOat2 in a time-dependent manner.
Title: Mouse organic anion transporter 2 (mOat2) mediates the transport of short chain fatty acid propionate.
there exists a sex- and species-related differential gene expression of the OAT2 isoform.
Title: Isolation, characterization and differential gene expression of multispecific organic anion transporter 2 in mice.
OAT2 in mouse kidney exhibiting gender differences (F > M) that appear in puberty and are caused by strong androgen inhibition and weak estrogen and progesterone stimulation
Title: Renal expression of organic anion transporter OAT2 in rats and mice is regulated by sex hormones.
Results indicate that mOAT2 plays a role for the transport of bumetanide on the luminal membranes of kidney proximal tubules.
Title: Mouse organic anion transporter 2 and 3 (mOAT2/3[Slc22a7/8]) mediates the renal transport of bumetanide.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

General gene information

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Markers

Slc22a7 (e-PCR), detects polymorphism
- UniSTS:463374

Slc22a7 (e-PCR), detects polymorphism
- UniSTS:545993

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables alpha-ketoglutarate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables alpha-ketoglutarate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables organic anion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables organic anion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables organic anion transmembrane transporter activity	TAS Traceable Author Statement more info	PubMed
enables prostaglandin transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables prostaglandin transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables sodium-independent organic anion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables sodium-independent organic anion transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in alpha-ketoglutarate transport	IDA Inferred from Direct Assay more info	PubMed
involved_in alpha-ketoglutarate transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in organic anion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within organic anion transport	TAS Traceable Author Statement more info	PubMed
involved_in prostaglandin transport	IDA Inferred from Direct Assay more info	PubMed
involved_in prostaglandin transport	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to stilbenoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basal plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: solute carrier family 22 member 7

Names: mOAT2; organic anion transporter 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_144856.2 → NP_659105.2 solute carrier family 22 member 7

See identical proteins and their annotated locations for NP_659105.2

Status: VALIDATED

Source sequence(s)

AK082865, AK143949

Consensus CDS

CCDS28829.1

UniProtKB/Swiss-Prot

Q3UNX2, Q8BUQ9, Q8K4S9, Q8R0M7, Q8R125, Q91WU2

UniProtKB/TrEMBL

A0A0R4J122

Related

ENSMUSP00000084234.6, ENSMUST00000087012.7

Conserved Domains (2) summary

cd06174
Location:146 → 511

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

TIGR00898
Location:11 → 521

2A0119; cation transport protein