Katnal1 katanin p60 subunit A-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Katnal1provided by MGI
Official Full Name: katanin p60 subunit A-like 1provided by MGI
Primary source: MGI:MGI:2387638
See related: Ensembl:ENSMUSG00000041298 AllianceGenome:MGI:2387638
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables microtubule severing ATPase activity. Acts upstream of or within microtubule severing and spermatogenesis. Located in microtubule cytoskeleton. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Orthologous to human KATNAL1 (katanin catalytic subunit A1 like 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in testis adult (RPKM 10.1), cerebellum adult (RPKM 7.7) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G3; 5 89.04 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (148808394..148865978, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (148871584..148929168, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The katanin A-subunits KATNA1 and KATNAL1 act co-operatively in mammalian meiosis and spermiogenesis to achieve male fertility.
Title: The katanin A-subunits KATNA1 and KATNAL1 act co-operatively in mammalian meiosis and spermiogenesis to achieve male fertility.
circ-Katnal1 Enhances Inflammatory Pyroptosis in Sepsis-Induced Liver Injury through the miR-31-5p/GSDMD Axis.
Title: circ-Katnal1 Enhances Inflammatory Pyroptosis in Sepsis-Induced Liver Injury through the miR-31-5p/GSDMD Axis.
Katanin p60 ATPase-containing subunit A-like 1 was predominant in the ovaries and oocytes, indicating its essential roles in oocyte meiosis. It was also revealed that p60 kataninlike 1 was concentrated at the spindle poles and colocalized and interacted with gammatubulin, indicating that it may be involved in pole organization.
Title: Microtubule‑severing protein Katanin p60 ATPase‑containing subunit A‑like 1 is involved in pole‑based spindle organization during mouse oocyte meiosis.
more active and more stable katanin subunit, KATNAL1, plays more important role in process elongation.
Title: KATNAL1 is a more active and stable isoform of katanin, and is expressed dominantly in neurons.
The identification of KATNAL1 as an essential regulator of male fertility provides a significant novel entry point into advancing our understanding of how SC microtubule dynamics promotes male fertility
Title: KATNAL1 regulation of sertoli cell microtubule dynamics is essential for spermiogenesis and male fertility.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule severing ATPase activity	IDA Inferred from Direct Assay more info	PubMed
enables microtubule severing ATPase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in microtubule severing	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within microtubule severing	IDA Inferred from Direct Assay more info	PubMed
involved_in microtubule severing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
part_of katanin complex	IEA Inferred from Electronic Annotation more info
part_of katanin complex	ISO Inferred from Sequence Orthology more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in microtubule	ISS Inferred from Sequence or Structural Similarity more info
is_active_in microtubule cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in spindle	ISO Inferred from Sequence Orthology more info
located_in spindle	ISS Inferred from Sequence or Structural Similarity more info
located_in spindle pole	ISO Inferred from Sequence Orthology more info
located_in spindle pole	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: katanin p60 ATPase-containing subunit A-like 1

Names: p60 katanin-like 1

NP_705800.1

EC 5.6.1.1

XP_006504891.1

EC 5.6.1.1

XP_006504892.1

EC 5.6.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153572.2 → NP_705800.1 katanin p60 ATPase-containing subunit A-like 1

See identical proteins and their annotated locations for NP_705800.1

Status: VALIDATED

Source sequence(s)

AC107720, AI844773, BC030434, BE653455

Consensus CDS

CCDS39404.1

UniProtKB/Swiss-Prot

Q8K0T4

Related

ENSMUSP00000043210.9, ENSMUST00000047257.15

Conserved Domains (1) summary

COG0464
Location:186 → 481

SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

148808394..148865978 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006504829.4 → XP_006504892.1 katanin p60 ATPase-containing subunit A-like 1 isoform X1

See identical proteins and their annotated locations for XP_006504892.1

UniProtKB/Swiss-Prot

Q8K0T4

Conserved Domains (1) summary

COG0464
Location:186 → 481

SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
XM_006504828.5 → XP_006504891.1 katanin p60 ATPase-containing subunit A-like 1 isoform X1

See identical proteins and their annotated locations for XP_006504891.1

UniProtKB/Swiss-Prot

Q8K0T4

Conserved Domains (1) summary

COG0464
Location:186 → 481

SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]