Ticam1 TIR domain containing adaptor molecule 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ticam1provided by MGI
Official Full Name: TIR domain containing adaptor molecule 1provided by MGI
Primary source: MGI:MGI:2147032
See related: Ensembl:ENSMUSG00000047123 AllianceGenome:MGI:2147032
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TRIF; TICAM-1
Summary: Enables signaling adaptor activity. Involved in several processes, including cellular response to oxidised low-density lipoprotein particle stimulus; positive regulation of canonical NF-kappaB signal transduction; and positive regulation of cytokine production. Acts upstream of or within several processes, including lipopolysaccharide-mediated signaling pathway; positive regulation of lymphocyte activation; and positive regulation of metabolic process. Located in cytosol and mitochondrion. Is expressed in brain and genitourinary system. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human TICAM1 (TIR domain containing adaptor molecule 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in duodenum adult (RPKM 44.7), small intestine adult (RPKM 31.1) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 D; 17 29.24 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (56576462..56583767, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (56269462..56276767, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ZCCHC3 modulates TLR3-mediated signaling by promoting recruitment of TRIF to TLR3.
Title: ZCCHC3 modulates TLR3-mediated signaling by promoting recruitment of TRIF to TLR3.
ferroptosis orchestrates neutrophil recruitment to injured myocardium by promoting adhesion of neutrophils to coronary vascular endothelial cells through a TLR4/TRIF/type I IFN signaling pathway.
Title: Ferroptotic cell death and TLR4/Trif signaling initiate neutrophil recruitment after heart transplantation.
TRIF K27-linked polyubiquitination and deubiquitination as a critical regulatory mechanism of TLR3/4-mediated innate immune responses.
Title: Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination.
The TRIF pathway plays an important role in protecting a microenvironment surrounding motor neurons by eliminating aberrantly activated astrocytes.
Title: Innate immune adaptor TRIF deficiency accelerates disease progression of ALS mice with accumulation of aberrantly activated astrocytes.
These data suggest that TLR3 signaling controls the onset and severity of acute pancreatitis.
Title: Loss of TLR3 and its downstream signaling accelerates acinar cell damage in the acute phase of pancreatitis.
Together, our findings demonstrate that TRIF signaling is required for caspase-11-dependent immune responses and lethality in endotoxemia and sepsis, and provide novel mechanistic insights into how LPS induces caspase-11 activation during bacterial infection.
Title: TRIF signaling is required for caspase-11-dependent immune responses and lethality in sepsis.
Findings confirm that signalling through MyD88 is the primary driver for Lipopolysaccharide-dependent NF-kappaB translocation to the nucleus. The pattern of NF-kappaB dynamics in TRIF-deficient cells does not, however, directly reflect the kinetics of TNFalpha promoter activation, supporting the concept that TRIF-dependent signalling plays an important role in the transcription of this cytokine.
Title: Lipopolysaccharide-induced NF-κB nuclear translocation is primarily dependent on MyD88, but TNFα expression requires TRIF and MyD88.
STING-mediated innate immune responses and dendritic cell maturation do not require TICAM-1 in myeloid lineage immune cells.
Title: TICAM-1 is dispensable in STING-mediated innate immune responses in myeloid immune cells.
Mice with myeloid cell specific TIR-domain-containing adapter-inducing interferon-beta (TRIF) knockout showed a trend towards accelerated onset of STZ-induced diabetes, while TRIF deficiency resulted in reduced IDO expression in vivo and in vitro. MyD88 signaling in myeloid cells is a critical pathogenic factor in autoimmune diabetes, which is antagonized by TRIF-dependent responses.
Title: Differential role of MyD88 and TRIF signaling in myeloid cells in the pathogenesis of autoimmune diabetes.
Findings suggest that Toll/IL-1R domain-containing adapter-inducing IFN-beta may be involved in the epileptogenesis of temporal lobe epilepsy, which would make it a potential therapeutic target for the treatment of epilepsy.
Title: TRIF contributes to epileptogenesis in temporal lobe epilepsy during TLR4 activation.

Submit: New GeneRIF Correction See all GeneRIFs (85)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (3) 1 citation
Endonuclease-mediated (5)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW547018 (e-PCR)
- UniSTS:181044

NoName (e-PCR)
- UniSTS:237669

AW046014 (e-PCR)
- UniSTS:166068

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables signaling adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables signaling adaptor activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of B cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of B cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within MyD88-independent toll-like receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in TRIF-dependent toll-like receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in TRIF-dependent toll-like receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in TRIF-dependent toll-like receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to oxidised low-density lipoprotein particle stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of chemokine production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of chemokine production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of interferon-beta production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within macrophage activation involved in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of macrophage cytokine production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of macrophage cytokine production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of macrophage cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of nitric oxide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of B cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of B cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of chemokine production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of chemokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytokine production involved in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of interferon-beta production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of macrophage cytokine production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of macrophage cytokine production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of macrophage cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of myeloid dendritic cell cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of natural killer cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of nitric oxide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of protein binding	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of tumor necrosis factor production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of tumor necrosis factor production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of type I interferon production	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of type I interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of type I interferon production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein-containing complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to exogenous dsRNA	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to exogenous dsRNA	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to exogenous dsRNA	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to exogenous dsRNA	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within response to lipopolysaccharide	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in toll-like receptor 3 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in toll-like receptor 3 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in toll-like receptor 4 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in toll-like receptor 4 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in toll-like receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of tumor necrosis factor production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of tumor necrosis factor production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of type I interferon production	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in autophagosome	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome	IEA Inferred from Electronic Annotation more info
is_active_in early endosome	ISO Inferred from Sequence Orthology more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endosome	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in endosome membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
part_of ripoptosome	IEA Inferred from Electronic Annotation more info
part_of ripoptosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: TIR domain-containing adapter molecule 1

Names: TIR domain-containing adapter protein inducing IFN-beta; TIR domain-containing adaptor inducing interferon-beta; toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta; toll-like receptor adaptor molecule 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.