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    Trim27 tripartite motif-containing 27 [ Mus musculus (house mouse) ]

    Gene ID: 19720, updated on 4-Jan-2025

    Summary

    Official Symbol
    Trim27provided by MGI
    Official Full Name
    tripartite motif-containing 27provided by MGI
    Primary source
    MGI:MGI:97904
    See related
    Ensembl:ENSMUSG00000021326 AllianceGenome:MGI:97904
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rfp; Gm19403
    Summary
    Predicted to enable identical protein binding activity; transcription coactivator activity; and ubiquitin-like protein transferase activity. Involved in innate immune response; negative regulation of viral transcription; and suppression of viral release by host. Acts upstream of or within negative regulation of transcription by RNA polymerase II and positive regulation of actin nucleation. Located in cytoplasm. Is expressed in several structures, including central nervous system; genitourinary system; liver; lung; and retina. Orthologous to human TRIM27 (tripartite motif containing 27). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in ovary adult (RPKM 33.3), adrenal adult (RPKM 32.0) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Trim27 in Genome Data Viewer
    Location:
    13 A3.1; 13 7.67 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (21363570..21378893)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (21179450..21194723)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA glutamine 7 (anticodon CTG) Neighboring gene nuclear encoded tRNA leucine 4 (anticodon CAA) Neighboring gene STARR-positive B cell enhancer ABC_E1870 Neighboring gene nuclear encoded tRNA leucine 1 (anticodon CAA) Neighboring gene predicted gene, 32420 Neighboring gene nuclear encoded tRNA arginine 3 (anticodon CCG)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (3) 
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding  
    enables SUMO transferase activity  
    enables identical protein binding  
    enables identical protein binding  
    enables protein binding PubMed 
    enables transcription coactivator activity  
    enables transcription coactivator activity  
    enables ubiquitin protein ligase activity  
    enables ubiquitin protein ligase activity  
    enables ubiquitin protein ligase activity  
    enables ubiquitin-protein transferase activity  
    enables ubiquitin-protein transferase activity  
    enables zinc ion binding  
    Items 1 - 25 of 36
    Process Evidence Code Pubs
    involved_in Arp2/3 complex-mediated actin nucleation  
    involved_in Arp2/3 complex-mediated actin nucleation  
    involved_in innate immune response  
    involved_in innate immune response PubMed 
    involved_in innate immune response  
    involved_in negative regulation of adaptive immune response  
    involved_in negative regulation of adaptive immune response  
    involved_in negative regulation of autophagy  
    involved_in negative regulation of autophagy  
    involved_in negative regulation of calcium ion import  
    involved_in negative regulation of calcium ion import  
    acts_upstream_of_or_within negative regulation of gene expression, epigenetic PubMed 
    involved_in negative regulation of interleukin-2 production  
    involved_in negative regulation of interleukin-2 production  
    involved_in negative regulation of protein kinase activity  
    involved_in negative regulation of protein kinase activity  
    involved_in negative regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II PubMed 
    involved_in negative regulation of tumor necrosis factor production  
    involved_in negative regulation of tumor necrosis factor production  
    involved_in negative regulation of type I interferon production  
    involved_in negative regulation of type I interferon production  
    involved_in negative regulation of viral transcription  
    involved_in negative regulation of viral transcription PubMed 
    involved_in negative regulation of viral transcription  
    involved_in positive regulation of DNA-binding transcription factor activity  
    involved_in positive regulation of DNA-templated transcription  
    acts_upstream_of_or_within positive regulation of actin nucleation PubMed 
    involved_in positive regulation of type II interferon production  
    involved_in positive regulation of type II interferon production  
    involved_in protein K63-linked ubiquitination  
    involved_in protein K63-linked ubiquitination  
    involved_in retrograde transport, endosome to Golgi  
    involved_in retrograde transport, endosome to Golgi  
    involved_in suppression of viral release by host PubMed 
    Items 1 - 25 of 36
    Component Evidence Code Pubs
    located_in PML body  
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytosol  
    located_in early endosome  
    located_in endosome  
    located_in endosome  
    located_in fibrillar center  
    located_in fibrillar center  
    located_in mitochondrion  
    located_in nuclear membrane PubMed 
    located_in nucleolus  
    located_in nucleoplasm PubMed 
    located_in nucleus  
    part_of retromer complex  
    part_of retromer complex  

    General protein information

    Preferred Names
    zinc finger protein RFP
    Names
    RING-type E3 ubiquitin transferase TRIM27
    ret finger protein
    tripartite motif protein 27
    tripartite motif-containing protein 27
    NP_033080.2
    XP_006516669.1
    XP_036013819.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429048.1NP_001415977.1  zinc finger protein RFP isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC138330
      UniProtKB/TrEMBL
      Q6NSS3
    2. NM_001429049.1NP_001415978.1  zinc finger protein RFP isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC138330
      UniProtKB/TrEMBL
      Q6NSS3
    3. NM_001429050.1NP_001415979.1  zinc finger protein RFP isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC138330
      UniProtKB/TrEMBL
      A0A1Y7VJ13
    4. NM_001429051.1NP_001415980.1  zinc finger protein RFP isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC138330
      UniProtKB/TrEMBL
      A0A1Y7VKW0
    5. NM_009054.4NP_033080.2  zinc finger protein RFP isoform 1

      See identical proteins and their annotated locations for NP_033080.2

      Status: VALIDATED

      Source sequence(s)
      AC138330
      Consensus CDS
      CCDS36607.1
      UniProtKB/Swiss-Prot
      Q62157, Q62158, Q8C2Q5, Q99LK1
      UniProtKB/TrEMBL
      Q6NSS3
      Related
      ENSMUSP00000021761.6, ENSMUST00000021761.13
      Conserved Domains (4) summary
      COG1196
      Location:140312
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd15814
      Location:315491
      SPRY_PRY_TRIM27; PRY/SPRY domain in tripartite motif-containing protein 27 (TRIM27), also known as RING finger protein 76 (RNF76)
      cd16594
      Location:1357
      RING-HC_TRIM11_like_C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins, TRIM11 and TRIM27, and similar proteins
      cd19762
      Location:94137
      Bbox2_TRIM7-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM7, TRIM27 and similar proteins

    RNA

    1. NR_190573.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC138330

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      21363570..21378893
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157926.1XP_036013819.1  zinc finger protein RFP isoform X1

      UniProtKB/Swiss-Prot
      Q62157, Q62158, Q8C2Q5, Q99LK1
      UniProtKB/TrEMBL
      Q6NSS3
      Conserved Domains (4) summary
      COG1196
      Location:140312
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd15814
      Location:315491
      SPRY_PRY_TRIM27; PRY/SPRY domain in tripartite motif-containing protein 27 (TRIM27), also known as RING finger protein 76 (RNF76)
      cd16594
      Location:1357
      RING-HC_TRIM11_like_C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins, TRIM11 and TRIM27, and similar proteins
      cd19762
      Location:94137
      Bbox2_TRIM7-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM7, TRIM27 and similar proteins
    2. XM_006516606.3XP_006516669.1  zinc finger protein RFP isoform X1

      See identical proteins and their annotated locations for XP_006516669.1

      UniProtKB/Swiss-Prot
      Q62157, Q62158, Q8C2Q5, Q99LK1
      UniProtKB/TrEMBL
      Q6NSS3
      Related
      ENSMUSP00000152730.2, ENSMUST00000222544.2
      Conserved Domains (4) summary
      COG1196
      Location:140312
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd15814
      Location:315491
      SPRY_PRY_TRIM27; PRY/SPRY domain in tripartite motif-containing protein 27 (TRIM27), also known as RING finger protein 76 (RNF76)
      cd16594
      Location:1357
      RING-HC_TRIM11_like_C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins, TRIM11 and TRIM27, and similar proteins
      cd19762
      Location:94137
      Bbox2_TRIM7-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM7, TRIM27 and similar proteins

    RNA

    1. XR_003950436.1 RNA Sequence

      Related
      ENSMUST00000223065.2
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