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    Aopep aminopeptidase O [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290963, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Aopepprovided by RGD
    Official Full Name
    aminopeptidase Oprovided by RGD
    Primary source
    RGD:1309592
    See related
    EnsemblRapid:ENSRNOG00000017505 AllianceGenome:RGD:1309592
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Apo; Npepo; RGD1309592
    Summary
    Predicted to enable metalloaminopeptidase activity and zinc ion binding activity. Predicted to be involved in proteolysis. Predicted to be active in nucleolus. Human ortholog(s) of this gene implicated in dystonia 31. Orthologous to human AOPEP (aminopeptidase O (putative)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 178.3), Heart (RPKM 176.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Aopep in Genome Data Viewer
    Location:
    17p14
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (1817001..2133008, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (1811281..2127316, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (507389..825062)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene patched 1 Neighboring gene uncharacterized LOC134482656 Neighboring gene small nucleolar RNA SNORA76 Neighboring gene FA complementation group C Neighboring gene microRNA 3074 Neighboring gene microRNA 24-1 Neighboring gene microRNA 27b Neighboring gene microRNA 23b Neighboring gene uncharacterized LOC134482655 Neighboring gene uncharacterized LOC134482654 Neighboring gene uncharacterized LOC102551048 Neighboring gene fructose-bisphosphatase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Aminopeptidase O contains a functional nucleolar localization signal and is implicated in vascular biology. Axton R, et al. J Cell Biochem, 2008 Mar 1. PMID 17803194
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metalloaminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    aminopeptidase O
    Names
    AP-O

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012346.2 → NP_001012346.2  aminopeptidase O

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/Swiss-Prot
      F1LRV1, P69527
      Related
      ENSRNOP00000107620.1, ENSRNOT00000160757.1
      Conserved Domains (2) summary
      pfam09127
      Location:709 → 821
      Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
      cl14813
      Location:244 → 640
      GluZincin; Gluzincin Peptidase family (thermolysin-like proteinases, TLPs) which includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      1817001..2133008 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276129.1 → XP_063132199.1  aminopeptidase O isoform X3

    2. XM_063276130.1 → XP_063132200.1  aminopeptidase O isoform X4

    3. XM_063276125.1 → XP_063132195.1  aminopeptidase O isoform X1

      UniProtKB/TrEMBL
      A0A8L2QC72
      Related
      ENSRNOP00000023638.7, ENSRNOT00000023638.8

    4. XM_063276126.1 → XP_063132196.1  aminopeptidase O isoform X1

      UniProtKB/TrEMBL
      A0A8L2QC72

    5. XM_017600471.3 → XP_017455960.1  aminopeptidase O isoform X1

      UniProtKB/TrEMBL
      A0A8L2QC72
      Conserved Domains (2) summary
      pfam09127
      Location:743 → 884
      Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
      cl14813
      Location:250 → 697
      GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

    6. XM_008771431.4 → XP_008769653.1  aminopeptidase O isoform X2

      See identical proteins and their annotated locations for XP_008769653.1

      UniProtKB/Swiss-Prot
      F1LRV1, P69527
      Conserved Domains (2) summary
      pfam09127
      Location:709 → 821
      Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
      cl14813
      Location:244 → 640
      GluZincin; Gluzincin Peptidase family (thermolysin-like proteinases, TLPs) which includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

    7. XM_008771432.4 → XP_008769654.1  aminopeptidase O isoform X2

      See identical proteins and their annotated locations for XP_008769654.1

      UniProtKB/Swiss-Prot
      F1LRV1, P69527
      Conserved Domains (2) summary
      pfam09127
      Location:709 → 821
      Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
      cl14813
      Location:244 → 640
      GluZincin; Gluzincin Peptidase family (thermolysin-like proteinases, TLPs) which includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

    8. XM_008771429.4 → XP_008769651.1  aminopeptidase O isoform X1

      See identical proteins and their annotated locations for XP_008769651.1

      UniProtKB/TrEMBL
      A0A8L2QC72
      Conserved Domains (2) summary
      pfam09127
      Location:743 → 884
      Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
      cl14813
      Location:250 → 697
      GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

    9. XM_063276127.1 → XP_063132197.1  aminopeptidase O isoform X2

      UniProtKB/Swiss-Prot
      F1LRV1, P69527

    10. XM_017600473.3 → XP_017455962.1  aminopeptidase O isoform X2

      UniProtKB/Swiss-Prot
      F1LRV1, P69527
      Conserved Domains (2) summary
      pfam09127
      Location:709 → 821
      Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
      cl14813
      Location:244 → 640
      GluZincin; Gluzincin Peptidase family (thermolysin-like proteinases, TLPs) which includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

    11. XM_063276133.1 → XP_063132203.1  aminopeptidase O isoform X7

    12. XM_063276131.1 → XP_063132201.1  aminopeptidase O isoform X5

    13. XM_063276132.1 → XP_063132202.1  aminopeptidase O isoform X6

    RNA

    1. XR_010058813.1 RNA Sequence

    2. XR_010058815.1 RNA Sequence

    3. XR_010058814.1 RNA Sequence

    4. XR_010058816.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P69527.2 GenPept UniProtKB/Swiss-Prot:P69527

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