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    B4galt6 beta-1,4-galactosyltransferase 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 65196, updated on 9-Dec-2024

    Summary

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    Official Symbol
    B4galt6provided by RGD
    Official Full Name
    beta-1,4-galactosyltransferase 6provided by RGD
    Primary source
    RGD:71046
    See related
    EnsemblRapid:ENSRNOG00000015895 AllianceGenome:RGD:71046
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity. Involved in glycosphingolipid biosynthetic process. Predicted to be located in Golgi cisterna membrane and Golgi membrane. Predicted to be active in Golgi apparatus. Orthologous to human B4GALT6 (beta-1,4-galactosyltransferase 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 145.5), Lung (RPKM 121.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See B4galt6 in Genome Data Viewer
    Location:
    18p12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (12233350..12290204, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (11958382..12015247, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (15462913..15525584)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551809 Neighboring gene transthyretin Neighboring gene uncharacterized LOC102551486 Neighboring gene importin 5, pseudogene 1 Neighboring gene uncharacterized LOC120098272

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. cDNA cloning and expression of human lactosylceramide synthase. Takizawa M, et al. Biochim Biophys Acta, 1999 May 18. PMID 10320813
    2. Purification, cDNA cloning, and expression of UDP-Gal: glucosylceramide beta-1,4-galactosyltransferase from rat brain. Nomura T, et al. J Biol Chem, 1998 May 29. PMID 9593693
    3. Lactosylceramide synthases encoded by B4galt5 and 6 genes are pivotal for neuronal generation and myelin formation in mice. Yoshihara T, et al. PLoS Genet, 2018 Aug. PMID 30114188, Free PMC Article
    4. Establishment of HeLa cell mutants deficient in sphingolipid-related genes using TALENs. Yamaji T, et al. PLoS One, 2014. PMID 24498430, Free PMC Article
    5. β4GalT6 is involved in the synthesis of lactosylceramide with less intensity than β4GalT5. Tokuda N, et al. Glycobiology, 2013 Oct. PMID 23882130

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables galactosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in central nervous system myelination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in central nervous system myelination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in central nervous system neuron axonogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in central nervous system neuron axonogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ganglioside biosynthetic process via lactosylceramide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ganglioside biosynthetic process via lactosylceramide ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glycosphingolipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycosphingolipid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lactosylceramide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron maturation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    beta-1,4-galactosyltransferase 6
    Names
    LacCer synthase
    Lactosylceramide Synthase
    UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 6
    UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6
    UDP-Gal:glucosylceramide beta-1,4-galactosyltransferase
    UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 6
    b4Gal-T6
    beta-1,4-GalTase 6
    beta4Gal-T6
    glucosylceramide beta-1,4-galactosyltransferase
    NP_113928.1
    XP_038953013.1
    XP_038953015.1
    XP_038953016.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031740.3 → NP_113928.1  beta-1,4-galactosyltransferase 6

      See identical proteins and their annotated locations for NP_113928.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/Swiss-Prot
      O88419
      UniProtKB/TrEMBL
      A6J2G4
      Related
      ENSRNOP00000082568.1, ENSRNOT00000111678.2
      Conserved Domains (1) summary
      cd00899
      Location:155 → 371
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      12233350..12290204 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097085.2 → XP_038953013.1  beta-1,4-galactosyltransferase 6 isoform X1

      UniProtKB/TrEMBL
      A0A0A0MXX9
      Conserved Domains (1) summary
      cd00899
      Location:130 → 346
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

    2. XM_039097087.2 → XP_038953015.1  beta-1,4-galactosyltransferase 6 isoform X2

      Conserved Domains (1) summary
      cd00899
      Location:111 → 327
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

    3. XM_039097088.2 → XP_038953016.1  beta-1,4-galactosyltransferase 6 isoform X2

      Related
      ENSRNOP00000021764.8, ENSRNOT00000021764.9
      Conserved Domains (1) summary
      cd00899
      Location:111 → 327
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88419.1 GenPept UniProtKB/Swiss-Prot:O88419

    Gene LinkOut

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