Tnks tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tnksprovided by MGI
Official Full Name: tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymeraseprovided by MGI
Primary source: MGI:MGI:1341087
See related: Ensembl:ENSMUSG00000031529 AllianceGenome:MGI:1341087
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ARTD5; TANK1; Parp5a; mTNKS1; 4930554K12Rik; D130072O21Rik
Summary: Predicted to enable NAD+-protein poly-ADP-ribosyltransferase activity; histone binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including positive regulation of canonical Wnt signaling pathway; post-translational protein modification; and regulation of chromosome organization. Predicted to act upstream of or within peptidyl-serine phosphorylation and peptidyl-threonine phosphorylation. Located in cytosol. Is expressed in several structures, including blastocyst; central nervous system; early embryo; neural retina; and oocyte. Orthologous to human TNKS (tankyrase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 23.3), whole brain E14.5 (RPKM 14.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 A4; 8 21.16 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (35296333..35432844, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (34829179..34965690, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MicroRNA-9-1 Attenuates Influenza A Virus Replication via Targeting Tankyrase 1.
Title: MicroRNA-9-1 Attenuates Influenza A Virus Replication via Targeting Tankyrase 1.
Tankyrase represses autoinflammation through the attenuation of TLR2 signaling.
Title: Tankyrase represses autoinflammation through the attenuation of TLR2 signaling.
Developmentally Programmed Tankyrase Activity Upregulates beta-Catenin and Licenses Progression of Embryonic Genome Activation.
Title: Developmentally Programmed Tankyrase Activity Upregulates β-Catenin and Licenses Progression of Embryonic Genome Activation.
The deubiquitinating enzyme USP25 binds tankyrase and regulates trafficking of the facilitative glucose transporter GLUT4 in adipocytes.
Title: The deubiquitinating enzyme USP25 binds tankyrase and regulates trafficking of the facilitative glucose transporter GLUT4 in adipocytes.
Study using Villin-creERT2;Tnks1-/-;Tnks2fl/fl mice, which harbored conventional Tnks1 deletion and inducible intestinal epithelium-specific Tnks2 knockout, shows that tankyrases regulate adult intestinal Lgr5+ stem cells and epithelium homeostasis by preventing cell death and promoting cell proliferation.
Title: Tankyrases maintain homeostasis of intestinal epithelium by preventing cell death.
Tank1/Tank2 inhibition aggravates kidney injury in the absence of CD2AP.
Title: Tankyrase inhibition aggravates kidney injury in the absence of CD2AP.
These structural insights will be invaluable for the functional and biophysical characterization of TNKS1/2, including the role of TNKS oligomerization in protein poly(ADP-ribosyl)ation (PARylation) and PARylation-dependent ubiquitylation.
Title: Structural insights into SAM domain-mediated tankyrase oligomerization.
analyses also reveal the structural basis for TNKS substrate recruitment, and shed light on the overall structure of TNKS that should help in developing specific inhibitors of Wnt/beta-catenin signaling
Title: Crystal structure of a Tankyrase-Axin complex and its implications for Axin turnover and Tankyrase substrate recruitment.
Data show that Tnks1 and 2 are broadly expressed during mouse development and are essential during kidney and lung development. In the kidney, blockage of tankyrase activity phenocopies the effect of blocking production of all Wnt ligands.
Title: Tankyrase is necessary for canonical Wnt signaling during kidney development.
Tankyrase-deficient mice exhibit increases in energy expenditure, fatty acid oxidation, and insulin-stimulated glucose utilization.
Title: Hypermetabolism, hyperphagia, and reduced adiposity in tankyrase-deficient mice.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8Mit125 (e-PCR), detects polymorphism
- UniSTS:131328

NoName (e-PCR)
- UniSTS:235872

AI662855 (e-PCR)
- UniSTS:165576

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-protein ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD+-protein ADP-ribosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables NAD+-protein-aspartate ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone binding	IEA Inferred from Electronic Annotation more info
enables histone binding	ISO Inferred from Sequence Orthology more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cellular response to nutrient	IEA Inferred from Electronic Annotation more info
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of telomere maintenance via telomere lengthening	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of telomere maintenance via telomere lengthening	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of telomeric DNA binding	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of telomere capping	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of telomere capping	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of telomere capping	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of telomere maintenance via telomerase	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of telomere maintenance via telomerase	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein auto-ADP-ribosylation	ISO Inferred from Sequence Orthology more info
involved_in protein auto-ADP-ribosylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to chromosome, telomeric region	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
involved_in protein localization to chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
involved_in protein poly-ADP-ribosylation	ISO Inferred from Sequence Orthology more info
involved_in protein poly-ADP-ribosylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein polyubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein polyubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
located_in chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in mitotic spindle pole	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle pole	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
part_of nuclear pore	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: poly [ADP-ribose] polymerase tankyrase-1

Names: ADP-ribosyltransferase diphtheria toxin-like 5; TRF1-interacting ankyrin-related ADP-ribose polymerase 1; protein poly-ADP-ribosyltransferase tankyrase-1; tankyrase I; tankyrase-1

NP_780300.2

EC 2.4.2.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175091.3 → NP_780300.2 poly [ADP-ribose] polymerase tankyrase-1

See identical proteins and their annotated locations for NP_780300.2

Status: VALIDATED

Source sequence(s)

AC122458, AK080913, BC057370

Consensus CDS

CCDS22242.1

UniProtKB/Swiss-Prot

Q6PFX9, Q8BX62

Related

ENSMUSP00000033929.5, ENSMUST00000033929.6

Conserved Domains (8) summary

cd09524
Location:1017 → 1082

SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily

smart00454
Location:1023 → 1080

SAM; Sterile alpha motif

cd00204
Location:669 → 794

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd01438
Location:1084 → 1306

tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...

pfam00644
Location:1098 → 1301

PARP; Poly(ADP-ribose) polymerase catalytic domain

pfam12796
Location:681 → 773

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:796 → 850

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:364 → 392

ANK; ANK repeat [structural motif]