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    Nhsl1 NHS like 1 [ Mus musculus (house mouse) ]

    Gene ID: 215819, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Nhsl1provided by MGI
    Official Full Name
    NHS like 1provided by MGI
    Primary source
    MGI:MGI:106390
    See related
    Ensembl:ENSMUSG00000039835 AllianceGenome:MGI:106390
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1357; A730096F01; D10Bwg0940e; 5730409E15Rik; A630035H13Rik
    Summary
    Predicted to be involved in cell differentiation. Is expressed in several structures, including alimentary system; brain; eye; male reproductive gland or organ; and trachea. Orthologous to human NHSL1 (NHS like 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 6.3), large intestine adult (RPKM 6.0) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nhsl1 in Genome Data Viewer
    Location:
    10 A3; 10 7.65 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (18193419..18409640)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (18317665..18533892)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8325 Neighboring gene coiled-coil domain containing 28A Neighboring gene predicted gene 10827 Neighboring gene STARR-seq mESC enhancer starr_25897 Neighboring gene predicted gene, 53616 Neighboring gene family with sequence similarity 54, member A pseudogene Neighboring gene STARR-seq mESC enhancer starr_25901 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:18228522-18228723 Neighboring gene STARR-seq mESC enhancer starr_25912 Neighboring gene heme binding protein 2 Neighboring gene ARFGEF family member 3 Neighboring gene STARR-seq mESC enhancer starr_25915 Neighboring gene STARR-seq mESC enhancer starr_25916 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:18384699-18384900 Neighboring gene predicted gene, 32926

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article
    2. Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Brady KP, et al. Genome Res, 1997 Nov. PMID 9371744, Free PMC Article
    3. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873
    4. KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility. Gu J, et al. Cell Death Differ, 2023 Jul. PMID 37142655, Free PMC Article
    5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1357

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    NHS-like protein 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163592.2 → NP_001157064.1  NHS-like protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC153561
      Consensus CDS
      CCDS48508.1
      UniProtKB/Swiss-Prot
      Q8CAF4
      Related
      ENSMUSP00000097631.4, ENSMUST00000100054.4
      Conserved Domains (1) summary
      pfam15273
      Location:255 → 879
      NHS; NHS-like

    2. NM_001405956.1 → NP_001392885.1  NHS-like protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC153561, AC153562
      UniProtKB/TrEMBL
      A0A140LIZ7
      Related
      ENSMUSP00000147021.2, ENSMUST00000207038.2

    3. NM_001405957.1 → NP_001392886.1  NHS-like protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC153561

    4. NM_001405958.1 → NP_001392887.1  NHS-like protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC153561

    5. NM_173390.4 → NP_775566.3  NHS-like protein 1 isoform 1

      See identical proteins and their annotated locations for NP_775566.3

      Status: VALIDATED

      Source sequence(s)
      AC153560, AC153561
      Consensus CDS
      CCDS35853.1
      UniProtKB/Swiss-Prot
      Q5DTY4, Q6P6Y7, Q8C8Z7, Q8CAF4, Q8K0R2, Q91YY6, Q9CYM2
      Related
      ENSMUSP00000040799.8, ENSMUST00000037341.14
      Conserved Domains (1) summary
      pfam15273
      Location:259 → 883
      NHS; NHS-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      18193419..18409640
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245007.2 → XP_030100867.1  NHS-like protein 1 isoform X11

      Conserved Domains (2) summary
      PRK11901
      Location:955 → 1144
      PRK11901; hypothetical protein; Reviewed
      pfam15273
      Location:1 → 604
      NHS; NHS-like

    2. XM_030245006.2 → XP_030100866.1  NHS-like protein 1 isoform X11

      Conserved Domains (2) summary
      PRK11901
      Location:955 → 1144
      PRK11901; hypothetical protein; Reviewed
      pfam15273
      Location:1 → 604
      NHS; NHS-like

    3. XM_006512686.5 → XP_006512749.1  NHS-like protein 1 isoform X2

      Conserved Domains (2) summary
      PRK11901
      Location:1308 → 1497
      PRK11901; hypothetical protein; Reviewed
      pfam15273
      Location:333 → 957
      NHS; NHS-like

    4. XM_006512691.5 → XP_006512754.1  NHS-like protein 1 isoform X11

      Conserved Domains (2) summary
      PRK11901
      Location:955 → 1144
      PRK11901; hypothetical protein; Reviewed
      pfam15273
      Location:1 → 604
      NHS; NHS-like

    5. XM_006512687.5 → XP_006512750.1  NHS-like protein 1 isoform X4

      Conserved Domains (2) summary
      PHA03307
      Location:1198 → 1548
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15273
      Location:303 → 927
      NHS; NHS-like

    6. XM_036155732.1 → XP_036011625.1  NHS-like protein 1 isoform X1

      Conserved Domains (2) summary
      PRK11901
      Location:1326 → 1515
      PRK11901; hypothetical protein; Reviewed
      pfam15273
      Location:350 → 975
      NHS; NHS-like

    7. XM_036155733.1 → XP_036011626.1  NHS-like protein 1 isoform X3

      Conserved Domains (2) summary
      PRK11901
      Location:1282 → 1471
      PRK11901; hypothetical protein; Reviewed
      pfam15273
      Location:306 → 931
      NHS; NHS-like

    8. XM_006512689.5 → XP_006512752.1  NHS-like protein 1 isoform X6

      Conserved Domains (2) summary
      PHA03307
      Location:1152 → 1502
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15273
      Location:257 → 881
      NHS; NHS-like

    9. XM_030245003.2 → XP_030100863.1  NHS-like protein 1 isoform X8

      Conserved Domains (2) summary
      PRK11901
      Location:1188 → 1377
      PRK11901; hypothetical protein; Reviewed
      pfam15273
      Location:213 → 837
      NHS; NHS-like

    10. XM_030245004.2 → XP_030100864.1  NHS-like protein 1 isoform X9

      Conserved Domains (2) summary
      PRK11901
      Location:1186 → 1375
      PRK11901; hypothetical protein; Reviewed
      pfam15273
      Location:211 → 835
      NHS; NHS-like

    11. XM_030245009.2 → XP_030100869.1  NHS-like protein 1 isoform X11

      Conserved Domains (2) summary
      PRK11901
      Location:955 → 1144
      PRK11901; hypothetical protein; Reviewed
      pfam15273
      Location:1 → 604
      NHS; NHS-like

    12. XM_030245008.2 → XP_030100868.1  NHS-like protein 1 isoform X11

      Conserved Domains (2) summary
      PRK11901
      Location:955 → 1144
      PRK11901; hypothetical protein; Reviewed
      pfam15273
      Location:1 → 604
      NHS; NHS-like
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CAF4.3 GenPept UniProtKB/Swiss-Prot:Q8CAF4

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