U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    WIPF3 WAS/WASL interacting protein family member 3 [ Homo sapiens (human) ]

    Gene ID: 644150, updated on 10-Dec-2024

    Summary

    Official Symbol
    WIPF3provided by HGNC
    Official Full Name
    WAS/WASL interacting protein family member 3provided by HGNC
    Primary source
    HGNC:HGNC:22004
    See related
    Ensembl:ENSG00000122574 MIM:612432; AllianceGenome:HGNC:22004
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CR16
    Summary
    Predicted to enable alpha-tubulin binding activity and gamma-tubulin binding activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation; endosomal transport; and exocytosis. Predicted to be located in cytosol. Predicted to be part of WASH complex. Predicted to be active in early endosome; recycling endosome; and synapse. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in ovary (RPKM 20.0), testis (RPKM 14.2) and 10 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See WIPF3 in Genome Data Viewer
    Location:
    7p14.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (29806508..29917061)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (29944291..30054757)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (29846124..29956677)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene MIR550A3 host gene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18048 Neighboring gene DPY19L2 pseudogene 3 Neighboring gene microRNA 550a-3 Neighboring gene zinc and ring finger 2 pseudogene 2 Neighboring gene Sharpr-MPRA regulatory region 13440 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:29823644-29824238 Neighboring gene hESC enhancers GRCh37_chr7:29832406-29833236 and GRCh37_chr7:29833237-29834066 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:29845860-29846769 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25802 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:29894186-29894764 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:29922848-29923743 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:29930193-29930732 Neighboring gene small nucleolar RNA U13 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:29968955-29969454 Neighboring gene secernin 1 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:30000281-30001070 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18049 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18050 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18051 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18052 Neighboring gene FKBP14 antisense RNA 1 Neighboring gene FKBP prolyl isomerase 14

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (18 hits/1264 screens)

    EBI GWAS Catalog

    Description
    Genetic variants near PDGFRA are associated with corneal curvature in Australians.
    EBI GWAS Catalog

    Interactions

    General gene information

    Clone Names

    • FLJ36931

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin binding  
    enables alpha-tubulin binding  
    enables gamma-tubulin binding  
    enables protein binding PubMed 
    Process Evidence Code Pubs
    involved_in Arp2/3 complex-mediated actin nucleation  
    involved_in cell differentiation  
    involved_in endocytic recycling  
    involved_in exocytosis  
    involved_in retrograde transport, endosome to Golgi  
    involved_in spermatogenesis  
    Component Evidence Code Pubs
    part_of WASH complex  
    located_in cytosol  
    is_active_in early endosome  
    is_active_in recycling endosome  

    General protein information

    Preferred Names
    WAS/WASL-interacting protein family member 3
    Names
    corticosteroids and regional expression protein 16 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080529.3 → NP_001073998.2  WAS/WASL-interacting protein family member 3 isoform 1

      See identical proteins and their annotated locations for NP_001073998.2

      Status: VALIDATED

      Source sequence(s)
      AC004912, AW105171, BX107905
      Consensus CDS
      CCDS56472.1
      UniProtKB/Swiss-Prot
      A6NGB9, B8ZZV2
      Related
      ENSP00000242140.6, ENST00000242140.10
      Conserved Domains (1) summary
      pfam02205
      Location:42 → 69
      WH2; WH2 motif
    2. NM_001391973.1 → NP_001378902.1  WAS/WASL-interacting protein family member 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC004912
      Consensus CDS
      CCDS94074.1
      UniProtKB/TrEMBL
      A0A0A0MSG0
      Related
      ENSP00000386790.1, ENST00000409123.5
      Conserved Domains (1) summary
      cd22077
      Location:42 → 71
      WH2_WAS_WASL-2_3; Wiskott Aldrich syndrome homology region 2 (WH2 motif) in WAS/WASL-interacting protein (WIP) family members 2 and 3

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      29806508..29917061
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017012522.2 → XP_016868011.1  WAS/WASL-interacting protein family member 3 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      29944291..30054757
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358802.1 → XP_054214777.1  WAS/WASL-interacting protein family member 3 isoform X1

    External link. Please review our privacy policy.