GLCCI1 glucocorticoid induced 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GLCCI1provided by HGNC
Official Full Name: glucocorticoid induced 1provided by HGNC
Primary source: HGNC:HGNC:18713
See related: Ensembl:ENSG00000106415 MIM:614283; AllianceGenome:HGNC:18713
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GCTR; GIG18; TSSN1; FAM117C
Summary: This gene encodes a protein of unknown function. Expression of this gene is induced by glucocorticoids and may be an early marker for glucocorticoid-induced apoptosis. Single nucleotide polymorphisms in this gene are associated with a decreased response to inhaled glucocorticoids in asthmatic patients. [provided by RefSeq, Feb 2012]
Expression: Broad expression in thyroid (RPKM 12.0), testis (RPKM 9.8) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7p21.3

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (7968796..8089080)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (8087312..8207580)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (8008427..8128710)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Glucocorticoid-Induced Transcript 1(GLCCI1) SNP rs37937 Is Associated With the Risk of Developing Allergic Rhinitis and the Response to Intranasal Corticosteroids in a Chinese Han Population.
Title: Glucocorticoid-Induced Transcript 1(GLCCI1) SNP rs37937 Is Associated With the Risk of Developing Allergic Rhinitis and the Response to Intranasal Corticosteroids in a Chinese Han Population.
GLCCI1 gene body methylation in peripheral blood is associated with asthma and asthma severity.
Title: GLCCI1 gene body methylation in peripheral blood is associated with asthma and asthma severity.
GLCCI1 and STIP1 variants are associated with asthma susceptibility and inhaled corticosteroid response in a Tunisian population.
Title: GLCCI1 and STIP1 variants are associated with asthma susceptibility and inhaled corticosteroid response in a Tunisian population.
Effects of STIP1 and GLCCI1 polymorphisms on the risk of childhood asthma and inhaled corticosteroid response in Chinese asthmatic children.
Title: Effects of STIP1 and GLCCI1 polymorphisms on the risk of childhood asthma and inhaled corticosteroid response in Chinese asthmatic children.
Hsa_circ_001659 serves as a novel diagnostic and prognostic biomarker for colorectal cancer.
Title: Hsa_circ_001659 serves as a novel diagnostic and prognostic biomarker for colorectal cancer.
GLCCI1 is a downstream molecule of the GC-GR cascade that acts as an antiapoptotic mediator in thymic T cells. Phosphorylated GLCCI1colocalized with microtubules in transfected cells. GR-dependent upregulation of GLCCI1 was proapoptotic in a cultured thymocyte cell line. Transgenic mice overexpressing human GLCCI1 had enlarged thymi with many thymocytes. GLCCI1 bound to both LC8 and PAK1. It reduced BIM expression.
Title: GLCCI1 is a novel protector against glucocorticoid-induced apoptosis in T cells.
this study found the GG genotype of GLCCI1 to be associated with better inhaled corticosteroids treatment response in asthma patients
Title: GLCCI1 Polymorphism rs37973 and Response to Treatment of Asthma With Inhaled Corticosteroids.
The rs37973 polymorphism of GLCCI1 is related to postoperative recovery from chronic rhinosinusitis (CRS) for individual sensitivity to glucocorticoids. Furthermore, AA genotype was associated with better treatment response in CRS.
Title: Impact of genetic variants of GLCCI1 on operational therapy in Chinese chronic rhinosinusitis patients.
GLCCI1 variant was associated with a significant decrease of the total lung capacity at 3 years after lung transplantation
Title: A single-nucleotide polymorphism in a gene modulating glucocorticoid sensitivity is associated with the decline in total lung capacity after lung transplantation.
The GLCCI1 rs37973 variant is a risk factor for glucocorticoid resistance in Chinese patients with SAR who receive short-term intranasal corticosteroids treatment. one genotype of GLCCI1, rs37973, was significantly associated with the INCS response. The effective rate of the GG group was lower than those of the AA and AG groups (AA vs. GG: 73.7% vs. 51.6%, P=0.007; AG vs. GG: 78.8% vs. 51.6%, P=0.000).
Title: Glucocorticoid-Induced Transcription Factor 1 (GLCCI1) Variant Impacts the Short-Term Response to Intranasal Corticosteroids in Chinese Han Patients with Seasonal Allergic Rhinitis.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Glucocorticoid therapy, response to MedGen: C3280689 OMIM: 614400 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
Genome-wide association study of intraocular pressure identifies the GLCCI1/ICA1 region as a glaucoma susceptibility locus. EBI GWAS Catalog EBI GWAS CatalogPubMed
Heritability and genetic association analysis of cognition in the&#x000a0;Diabetes Heart Study. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D7S2258 (e-PCR)
- UniSTS:153611

RH79779 (e-PCR)
- UniSTS:84493

A002M35 (e-PCR)
- UniSTS:59453

RH66241 (e-PCR)
- UniSTS:140

GDB:3755098 (e-PCR)
- UniSTS:36509

RH118687 (e-PCR)
- UniSTS:138182

G35278 (e-PCR)
- UniSTS:32999

GDB:1318386 (e-PCR)
- UniSTS:74226

SHGC-55956 (e-PCR)
- UniSTS:77299

D20S1004 (e-PCR)
- UniSTS:154620

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: glucocorticoid-induced transcript 1 protein

Names: glucocorticoid induced transcript 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.