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    ZNRF2 zinc and ring finger 2 [ Homo sapiens (human) ]

    Gene ID: 223082, updated on 10-Dec-2024

    Summary

    Official Symbol
    ZNRF2provided by HGNC
    Official Full Name
    zinc and ring finger 2provided by HGNC
    Primary source
    HGNC:HGNC:22316
    See related
    Ensembl:ENSG00000180233 MIM:612061; AllianceGenome:HGNC:22316
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RNF202
    Summary
    Enables ubiquitin protein ligase activity. Involved in positive regulation of autophagosome-lysosome fusion. Located in cytoplasmic vesicle membrane; nuclear lumen; and plasma membrane. Part of protein-containing complex. Is active in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis (RPKM 15.0), colon (RPKM 12.4) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ZNRF2 in Genome Data Viewer
    Location:
    7p14.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (30284597..30367689)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (30422290..30505386)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (30324213..30407305)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25806 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18059 Neighboring gene uncharacterized LOC105375217 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25807 Neighboring gene uncharacterized LOC124901607 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25808 Neighboring gene uncharacterized LOC105375218 Neighboring gene HNF1 motif-containing MPRA enhancer 259 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25809 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18060 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18061 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18062 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18063 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18064 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18065 Neighboring gene microRNA 550a-1 Neighboring gene microRNA 550b-1 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:30358457-30358625 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25810 Neighboring gene Sharpr-MPRA regulatory region 6335 Neighboring gene uncharacterized protein DKFZp586I1420 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:30430683-30431301 Neighboring gene long intergenic non-protein coding RNA 1176

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of ZNRF2 PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding  
    enables ubiquitin protein ligase activity  
    enables ubiquitin protein ligase activity PubMed 
    Component Evidence Code Pubs
    located_in cell projection  
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasmic vesicle membrane PubMed 
    located_in cytosol  
    located_in endosome membrane  
    located_in fibrillar center  
    is_active_in intracellular membrane-bounded organelle  
    is_active_in intracellular membrane-bounded organelle PubMed 
    located_in intracellular membrane-bounded organelle  
    located_in lysosomal membrane  
    is_active_in membrane  
    located_in nucleoplasm  
    located_in plasma membrane PubMed 
    located_in presynaptic membrane  
    part_of protein-containing complex PubMed 

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase ZNRF2
    Names
    RING finger protein 202
    RING-type E3 ubiquitin transferase ZNRF2
    protein Ells2
    zinc and ring finger 2, E3 ubiquitin protein ligase
    zinc finger/RING finger 2
    zinc/RING finger protein 2
    NP_667339.1
    XP_047276004.1
    XP_054213584.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_147128.4 → NP_667339.1  E3 ubiquitin-protein ligase ZNRF2

      See identical proteins and their annotated locations for NP_667339.1

      Status: VALIDATED

      Source sequence(s)
      AF513707, AF527533, AK025240
      Consensus CDS
      CCDS5426.1
      UniProtKB/Swiss-Prot
      Q8NHG8
      UniProtKB/TrEMBL
      A0A090N8Y8
      Related
      ENSP00000323879.4, ENST00000323037.5
      Conserved Domains (1) summary
      pfam13639
      Location:197 → 237
      zf-RING_2; Ring finger domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      30284597..30367689
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420048.1 → XP_047276004.1  E3 ubiquitin-protein ligase ZNRF2 isoform X1

      UniProtKB/Swiss-Prot
      Q8NHG8
      UniProtKB/TrEMBL
      A0A090N8Y8

    RNA

    1. XR_007059991.1 RNA Sequence

    2. XR_926925.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      30422290..30505386
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054357609.1 → XP_054213584.1  E3 ubiquitin-protein ligase ZNRF2 isoform X1

      UniProtKB/Swiss-Prot
      Q8NHG8
      UniProtKB/TrEMBL
      A0A090N8Y8

    RNA

    1. XR_008487541.1 RNA Sequence

    2. XR_008487542.1 RNA Sequence

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