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    GPS1 G protein pathway suppressor 1 [ Homo sapiens (human) ]

    Gene ID: 2873, updated on 10-Dec-2024

    Summary

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    Official Symbol
    GPS1provided by HGNC
    Official Full Name
    G protein pathway suppressor 1provided by HGNC
    Primary source
    HGNC:HGNC:4549
    See related
    Ensembl:ENSG00000169727 MIM:601934; AllianceGenome:HGNC:4549
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CSN1; SGN1; COPS1
    Summary
    This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. [provided by RefSeq, Mar 2016]
    Expression
    Ubiquitous expression in kidney (RPKM 28.1), testis (RPKM 27.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GPS1 in Genome Data Viewer
    Location:
    17q25.3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (82050932..82057470)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (82918090..82924628)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (80008808..80015346)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9184 Neighboring gene DCXR divergent transcript Neighboring gene dicarbonyl and L-xylulose reductase Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:80009332-80010001 Neighboring gene RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Neighboring gene dihydrouridine synthase 1 like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:80022320-80023048 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9188 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9189 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9190 Neighboring gene MPRA-validated peak3028 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:80038893-80039778 Neighboring gene fatty acid synthase Neighboring gene small nucleolar RNA, C/D box 134

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Bioinformatics analysis of GPS1 expression and biological function in breast cancer. Wei H, et al. J Cancer Res Clin Oncol, 2024 Jan 30. PMID 38289496, Free PMC Article
    2. UV-dependent phosphorylation of COP9/signalosome in UV-induced apoptosis. Dubois EL, et al. Oncol Rep, 2016 May. PMID 26986008, Free PMC Article
    3. CSN1 inhibits c-Jun phosphorylation and down-regulates ectopic expression of JNK1. Tsuge T, et al. Protein Cell, 2011 May. PMID 21604193, Free PMC Article
    4. CSN1 facilitates proliferation and migration of hepatocellular carcinoma cells by upregulating cyclin A2 expression. Fu H, et al. Mol Med Rep, 2021 Jan. PMID 33200803, Free PMC Article
    5. CSN1 Somatic Mutations in Penile Squamous Cell Carcinoma. Feber A, et al. Cancer Res, 2016 Aug 15. PMID 27325650, Free PMC Article

    See all (153) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Bioinformatics analysis of GPS1 expression and biological function in breast cancer.
      Title: Bioinformatics analysis of GPS1 expression and biological function in breast cancer.
    2. CSN1 facilitates proliferation and migration of hepatocellular carcinoma cells by upregulating cyclin A2 expression.
      Title: CSN1 facilitates proliferation and migration of hepatocellular carcinoma cells by upregulating cyclin A2 expression.
    3. We identified recurrent mutations in the novel penile cancer tumor suppressor genes CSN1(GPS1) and FAT1
      Title: CSN1 Somatic Mutations in Penile Squamous Cell Carcinoma.
    4. CSN1 appears to play a role not only in DNA repair but also in UV-induced apoptosis.
      Title: UV-dependent phosphorylation of COP9/signalosome in UV-induced apoptosis.
    5. We analyzed whether CSN1 alone can increase DEN1 degradation in HeLa cells.these data suggest that the COP9 signalosome supports proteasome-dependent protein degradation of DEN1/DenA in fungi and in human cells.
      Title: Control of multicellular development by the physically interacting deneddylases DEN1/DenA and COP9 signalosome.
    6. An increased level of CSN1 and CSN5 as an important part of the ubiquitin proteasome system (UPS) might be associated with the pathophysiology of preeclampsia.
      Title: Altered expression of COP9 signalosome proteins in preeclampsia.
    7. CSN1 inhibits c-Jun phosphorylation without affecting its protein stability.
      Title: CSN1 inhibits c-Jun phosphorylation and down-regulates ectopic expression of JNK1.
    8. The N-terminal half of CSN1/GPS1 is required to repress c-fos expression and to inhibit AP-1 and SRE transactivation, while the C-terminal half allows integration of the protein into the COP9 signalosome.
      Title: The subunit 1 of the COP9 signalosome suppresses gene expression through its N-terminal domain and incorporates into the complex through the PCI domain.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr is identified to have a physical interaction with G protein pathway suppressor 1 (GPS1; COPS1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC71287

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase inhibitor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in JNK cascade TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein deneddylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein neddylation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of protein neddylation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of COP9 signalosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COP9 signalosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of COP9 signalosome IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of COP9 signalosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    COP9 signalosome complex subunit 1
    Names
    JAB1-containing signalosome subunit 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001321089.3 → NP_001308018.1  COP9 signalosome complex subunit 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC135056
      UniProtKB/TrEMBL
      A0A9L9PXT0, B4DND6
      Related
      ENSP00000516490.1, ENST00000706669.1
      Conserved Domains (2) summary
      pfam01399
      Location:392 → 496
      PCI; PCI domain
      pfam10602
      Location:195 → 377
      RPN7; 26S proteasome subunit RPN7

    2. NM_001321090.3 → NP_001308019.1  COP9 signalosome complex subunit 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC135056
      UniProtKB/TrEMBL
      B4DND6
      Conserved Domains (2) summary
      pfam01399
      Location:388 → 492
      PCI; PCI domain
      pfam10602
      Location:191 → 373
      RPN7; 26S proteasome subunit RPN7

    3. NM_001321091.3 → NP_001308020.1  COP9 signalosome complex subunit 1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC135056
      UniProtKB/TrEMBL
      B4DND6
      Conserved Domains (2) summary
      pfam01399
      Location:387 → 491
      PCI; PCI domain
      pfam10602
      Location:191 → 372
      RPN7; 26S proteasome subunit RPN7

    4. NM_001321092.3 → NP_001308021.1  COP9 signalosome complex subunit 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC135056
      Consensus CDS
      CCDS82226.1
      UniProtKB/TrEMBL
      B4DND6
      Related
      ENSP00000462265.1, ENST00000578552.6
      Conserved Domains (2) summary
      pfam01399
      Location:320 → 424
      PCI; PCI domain
      pfam10602
      Location:123 → 305
      RPN7; 26S proteasome subunit RPN7

    5. NM_001321093.3 → NP_001308022.1  COP9 signalosome complex subunit 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC135056
      Consensus CDS
      CCDS82228.1
      UniProtKB/TrEMBL
      B4DND6, C9JFE4
      Related
      ENSP00000313569.4, ENST00000320548.8
      Conserved Domains (2) summary
      pfam01399
      Location:304 → 408
      PCI; PCI domain
      pfam10602
      Location:107 → 289
      RPN7; 26S proteasome subunit RPN7

    6. NM_001330539.3 → NP_001317468.1  COP9 signalosome complex subunit 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC135056
      Consensus CDS
      CCDS82227.1
      UniProtKB/TrEMBL
      A0A096LP07, B4DND6
      Related
      ENSP00000485330.1, ENST00000623691.3
      Conserved Domains (2) summary
      pfam01399
      Location:319 → 423
      PCI; PCI domain
      pfam10602
      Location:123 → 304
      RPN7; 26S proteasome subunit RPN7

    7. NM_001330541.3 → NP_001317470.1  COP9 signalosome complex subunit 1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC135056
      Consensus CDS
      CCDS82225.1
      UniProtKB/TrEMBL
      A0A096LPJ3, B4DND6
      Related
      ENSP00000485641.1, ENST00000624957.3
      Conserved Domains (2) summary
      pfam01399
      Location:323 → 427
      PCI; PCI domain
      pfam10602
      Location:127 → 308
      RPN7; 26S proteasome subunit RPN7

    8. NM_001394759.1 → NP_001381688.1  COP9 signalosome complex subunit 1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC135056
      UniProtKB/TrEMBL
      A0A9L9PX62, B4DND6
      Related
      ENSP00000516491.1, ENST00000706670.1
      Conserved Domains (1) summary
      COG5187
      Location:235 → 533
      RPN7; 26S proteasome regulatory complex component, contains PCI domain [Posttranslational modification, protein turnover, chaperones]

    9. NM_001394760.1 → NP_001381689.1  COP9 signalosome complex subunit 1 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC135056
      UniProtKB/TrEMBL
      B4DND6
      Conserved Domains (1) summary
      COG5187
      Location:207 → 506
      RPN7; 26S proteasome regulatory complex component, contains PCI domain [Posttranslational modification, protein turnover, chaperones]

    10. NM_001394761.1 → NP_001381690.1  COP9 signalosome complex subunit 1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC135056
      Consensus CDS
      CCDS92418.1
      UniProtKB/TrEMBL
      A8K070, B4DND6
      Related
      ENSP00000485035.1, ENST00000623761.3
      Conserved Domains (2) summary
      pfam01399
      Location:359 → 463
      PCI; PCI domain
      pfam10602
      Location:163 → 344
      RPN7; 26S proteasome subunit RPN7

    11. NM_001394762.1 → NP_001381691.1  COP9 signalosome complex subunit 1 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC135056
      UniProtKB/TrEMBL
      B4DND6
      Conserved Domains (1) summary
      COG5187
      Location:155 → 454
      RPN7; 26S proteasome regulatory complex component, contains PCI domain [Posttranslational modification, protein turnover, chaperones]

    12. NM_001394763.1 → NP_001381692.1  COP9 signalosome complex subunit 1 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC135056
      UniProtKB/TrEMBL
      B4DND6
      Conserved Domains (1) summary
      COG5187
      Location:155 → 454
      RPN7; 26S proteasome regulatory complex component, contains PCI domain [Posttranslational modification, protein turnover, chaperones]

    13. NM_001394764.1 → NP_001381693.1  COP9 signalosome complex subunit 1 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC135056
      UniProtKB/TrEMBL
      B4DND6
      Conserved Domains (1) summary
      COG5187
      Location:155 → 453
      RPN7; 26S proteasome regulatory complex component, contains PCI domain [Posttranslational modification, protein turnover, chaperones]

    14. NM_001394765.1 → NP_001381694.1  COP9 signalosome complex subunit 1 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC135056
      UniProtKB/TrEMBL
      B4DND6
      Conserved Domains (2) summary
      pfam01399
      Location:308 → 412
      PCI; PCI domain
      pfam10602
      Location:111 → 293
      RPN7; 26S proteasome subunit RPN7

    15. NM_001394766.1 → NP_001381695.1  COP9 signalosome complex subunit 1 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC135056
      UniProtKB/TrEMBL
      B4DND6
      Conserved Domains (2) summary
      pfam01399
      Location:308 → 412
      PCI; PCI domain
      pfam10602
      Location:111 → 293
      RPN7; 26S proteasome subunit RPN7

    16. NM_001394767.1 → NP_001381696.1  COP9 signalosome complex subunit 1 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC135056
      UniProtKB/TrEMBL
      B4DND6
      Conserved Domains (2) summary
      pfam01399
      Location:308 → 412
      PCI; PCI domain
      pfam10602
      Location:111 → 293
      RPN7; 26S proteasome subunit RPN7

    17. NM_001394768.1 → NP_001381697.1  COP9 signalosome complex subunit 1 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC135056
      UniProtKB/TrEMBL
      B4DND6
      Conserved Domains (2) summary
      pfam01399
      Location:307 → 411
      PCI; PCI domain
      pfam10602
      Location:111 → 292
      RPN7; 26S proteasome subunit RPN7

    18. NM_001394769.1 → NP_001381698.1  COP9 signalosome complex subunit 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC135056
      Consensus CDS
      CCDS82228.1
      UniProtKB/TrEMBL
      B4DND6, C9JFE4
      Conserved Domains (2) summary
      pfam01399
      Location:304 → 408
      PCI; PCI domain
      pfam10602
      Location:107 → 289
      RPN7; 26S proteasome subunit RPN7

    19. NM_001394770.1 → NP_001381699.1  COP9 signalosome complex subunit 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC135056
      Consensus CDS
      CCDS82228.1
      UniProtKB/TrEMBL
      B4DND6, C9JFE4
      Conserved Domains (2) summary
      pfam01399
      Location:304 → 408
      PCI; PCI domain
      pfam10602
      Location:107 → 289
      RPN7; 26S proteasome subunit RPN7

    20. NM_001394771.1 → NP_001381700.1  COP9 signalosome complex subunit 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC135056
      Consensus CDS
      CCDS82228.1
      UniProtKB/TrEMBL
      B4DND6, C9JFE4
      Conserved Domains (2) summary
      pfam01399
      Location:304 → 408
      PCI; PCI domain
      pfam10602
      Location:107 → 289
      RPN7; 26S proteasome subunit RPN7

    21. NM_001394772.1 → NP_001381701.1  COP9 signalosome complex subunit 1 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC135056
      UniProtKB/TrEMBL
      B4DND6
      Conserved Domains (2) summary
      pfam01399
      Location:303 → 407
      PCI; PCI domain
      pfam10602
      Location:107 → 288
      RPN7; 26S proteasome subunit RPN7

    22. NM_001394773.1 → NP_001381702.1  COP9 signalosome complex subunit 1 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC135056
      UniProtKB/TrEMBL
      B4DND6
      Conserved Domains (2) summary
      pfam01399
      Location:303 → 407
      PCI; PCI domain
      pfam10602
      Location:107 → 288
      RPN7; 26S proteasome subunit RPN7

    23. NM_001394774.1 → NP_001381703.1  COP9 signalosome complex subunit 1 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC135056
      UniProtKB/TrEMBL
      B4DND6
      Conserved Domains (1) summary
      COG5187
      Location:167 → 439
      RPN7; 26S proteasome regulatory complex component, contains PCI domain [Posttranslational modification, protein turnover, chaperones]

    24. NM_001394775.1 → NP_001381704.1  COP9 signalosome complex subunit 1 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AC135056
      UniProtKB/TrEMBL
      B4DND6
      Conserved Domains (1) summary
      COG5187
      Location:163 → 435
      RPN7; 26S proteasome regulatory complex component, contains PCI domain [Posttranslational modification, protein turnover, chaperones]

    25. NM_001394776.1 → NP_001381705.1  COP9 signalosome complex subunit 1 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC135056
      UniProtKB/TrEMBL
      B4DND6
      Conserved Domains (1) summary
      COG5187
      Location:155 → 427
      RPN7; 26S proteasome regulatory complex component, contains PCI domain [Posttranslational modification, protein turnover, chaperones]

    26. NM_001394777.1 → NP_001381706.1  COP9 signalosome complex subunit 1 isoform 21

      Status: REVIEWED

      Source sequence(s)
      AC135056
      UniProtKB/TrEMBL
      B4DND6
      Conserved Domains (1) summary
      COG5187
      Location:167 → 418
      RPN7; 26S proteasome regulatory complex component, contains PCI domain [Posttranslational modification, protein turnover, chaperones]

    27. NM_004127.7 → NP_004118.3  COP9 signalosome complex subunit 1 isoform 2

      See identical proteins and their annotated locations for NP_004118.3

      Status: REVIEWED

      Source sequence(s)
      AC135056
      Consensus CDS
      CCDS32774.1
      UniProtKB/Swiss-Prot
      Q13098, Q8NA10, Q9BWL1
      UniProtKB/TrEMBL
      B4DND6
      Related
      ENSP00000302873.6, ENST00000306823.10
      Conserved Domains (2) summary
      pfam01399
      Location:324 → 428
      PCI; PCI domain
      pfam10602
      Location:127 → 309
      RPN7; 26S proteasome subunit RPN7

    28. NM_212492.4 → NP_997657.1  COP9 signalosome complex subunit 1 isoform 1

      See identical proteins and their annotated locations for NP_997657.1

      Status: REVIEWED

      Source sequence(s)
      AC135056
      Consensus CDS
      CCDS11800.1
      UniProtKB/TrEMBL
      B4DND6
      Related
      ENSP00000376167.2, ENST00000392358.6
      Conserved Domains (2) summary
      pfam01399
      Location:360 → 464
      PCI; PCI domain
      pfam10602
      Location:163 → 345
      RPN7; 26S proteasome subunit RPN7

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      82050932..82057470
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047435841.1 → XP_047291797.1  COP9 signalosome complex subunit 1 isoform X16

      UniProtKB/TrEMBL
      B4DND6

    2. XM_047435845.1 → XP_047291801.1  COP9 signalosome complex subunit 1 isoform X19

      UniProtKB/TrEMBL
      B4DND6

    3. XM_047435847.1 → XP_047291803.1  COP9 signalosome complex subunit 1 isoform X21

      UniProtKB/TrEMBL
      B4DND6

    4. XM_047435829.1 → XP_047291785.1  COP9 signalosome complex subunit 1 isoform X1

      UniProtKB/TrEMBL
      B4DND6

    5. XM_047435836.1 → XP_047291792.1  COP9 signalosome complex subunit 1 isoform X11

      UniProtKB/TrEMBL
      B4DND6

    6. XM_017024524.3 → XP_016880013.1  COP9 signalosome complex subunit 1 isoform X2

      UniProtKB/TrEMBL
      B4DND6

    7. XM_047435837.1 → XP_047291793.1  COP9 signalosome complex subunit 1 isoform X12

      UniProtKB/TrEMBL
      B4DND6

    8. XM_047435830.1 → XP_047291786.1  COP9 signalosome complex subunit 1 isoform X3

      UniProtKB/TrEMBL
      B4DND6

    9. XM_047435832.1 → XP_047291788.1  COP9 signalosome complex subunit 1 isoform X6

      UniProtKB/TrEMBL
      B4DND6

    10. XM_047435839.1 → XP_047291795.1  COP9 signalosome complex subunit 1 isoform X14

      UniProtKB/TrEMBL
      B4DND6

    11. XM_047435846.1 → XP_047291802.1  COP9 signalosome complex subunit 1 isoform X20

      UniProtKB/TrEMBL
      B4DND6

    12. XM_047435850.1 → XP_047291806.1  COP9 signalosome complex subunit 1 isoform X1

      UniProtKB/TrEMBL
      B4DND6

    13. XM_047435851.1 → XP_047291807.1  COP9 signalosome complex subunit 1 isoform X2

      UniProtKB/TrEMBL
      B4DND6

    14. XM_047435855.1 → XP_047291811.1  COP9 signalosome complex subunit 1 isoform X12

      UniProtKB/TrEMBL
      B4DND6

    15. XM_047435854.1 → XP_047291810.1  COP9 signalosome complex subunit 1 isoform X3

      UniProtKB/TrEMBL
      B4DND6

    16. XM_005256350.2 → XP_005256407.1  COP9 signalosome complex subunit 1 isoform X4

      UniProtKB/TrEMBL
      B4DND6
      Conserved Domains (2) summary
      pfam01399
      Location:392 → 496
      PCI; PCI domain
      pfam10602
      Location:195 → 377
      RPN7; 26S proteasome subunit RPN7

    17. XM_047435831.1 → XP_047291787.1  COP9 signalosome complex subunit 1 isoform X5

      UniProtKB/TrEMBL
      B4DND6

    18. XM_005256353.2 → XP_005256410.1  COP9 signalosome complex subunit 1 isoform X8

      UniProtKB/TrEMBL
      B4DND6
      Conserved Domains (2) summary
      pfam01399
      Location:388 → 492
      PCI; PCI domain
      pfam10602
      Location:191 → 373
      RPN7; 26S proteasome subunit RPN7

    19. XM_017024525.2 → XP_016880014.1  COP9 signalosome complex subunit 1 isoform X10

      UniProtKB/TrEMBL
      B4DND6

    20. XM_047435833.1 → XP_047291789.1  COP9 signalosome complex subunit 1 isoform X7

      UniProtKB/TrEMBL
      B4DND6

    21. XM_047435838.1 → XP_047291794.1  COP9 signalosome complex subunit 1 isoform X13

      UniProtKB/TrEMBL
      B4DND6

    22. XM_047435840.1 → XP_047291796.1  COP9 signalosome complex subunit 1 isoform X15

      UniProtKB/TrEMBL
      B4DND6

    23. XM_047435835.1 → XP_047291791.1  COP9 signalosome complex subunit 1 isoform X9

      UniProtKB/TrEMBL
      B4DND6

    24. XM_047435842.1 → XP_047291798.1  COP9 signalosome complex subunit 1 isoform X17

      UniProtKB/TrEMBL
      B4DND6

    25. XM_047435843.1 → XP_047291799.1  COP9 signalosome complex subunit 1 isoform X18

      UniProtKB/TrEMBL
      B4DND6

    26. XM_047435849.1 → XP_047291805.1  COP9 signalosome complex subunit 1 isoform X1

      UniProtKB/TrEMBL
      B4DND6

    27. XM_047435853.1 → XP_047291809.1  COP9 signalosome complex subunit 1 isoform X3

      UniProtKB/TrEMBL
      B4DND6

    28. XM_017024531.3 → XP_016880020.1  COP9 signalosome complex subunit 1 isoform X6

      UniProtKB/TrEMBL
      B4DND6

    29. XM_005256359.3 → XP_005256416.1  COP9 signalosome complex subunit 1 isoform X22

      UniProtKB/TrEMBL
      B4DND6
      Conserved Domains (2) summary
      pfam01399
      Location:324 → 428
      PCI; PCI domain
      pfam10602
      Location:127 → 309
      RPN7; 26S proteasome subunit RPN7

    30. XM_047435848.1 → XP_047291804.1  COP9 signalosome complex subunit 1 isoform X23

      UniProtKB/TrEMBL
      B4DND6

    31. XM_005256360.5 → XP_005256417.1  COP9 signalosome complex subunit 1 isoform X24

      UniProtKB/TrEMBL
      B4DND6
      Conserved Domains (2) summary
      pfam01399
      Location:320 → 424
      PCI; PCI domain
      pfam10602
      Location:123 → 305
      RPN7; 26S proteasome subunit RPN7

    32. XM_017024527.3 → XP_016880016.1  COP9 signalosome complex subunit 1 isoform X25

      UniProtKB/TrEMBL
      B4DND6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      82918090..82924628
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054315851.1 → XP_054171826.1  COP9 signalosome complex subunit 1 isoform X16

      UniProtKB/TrEMBL
      B4DND6

    2. XM_054315854.1 → XP_054171829.1  COP9 signalosome complex subunit 1 isoform X19

      UniProtKB/TrEMBL
      B4DND6

    3. XM_054315856.1 → XP_054171831.1  COP9 signalosome complex subunit 1 isoform X21

      UniProtKB/TrEMBL
      B4DND6

    4. XM_054315836.1 → XP_054171811.1  COP9 signalosome complex subunit 1 isoform X1

      UniProtKB/TrEMBL
      B4DND6

    5. XM_054315846.1 → XP_054171821.1  COP9 signalosome complex subunit 1 isoform X11

      UniProtKB/TrEMBL
      B4DND6

    6. XM_054315837.1 → XP_054171812.1  COP9 signalosome complex subunit 1 isoform X2

      UniProtKB/TrEMBL
      B4DND6

    7. XM_054315847.1 → XP_054171822.1  COP9 signalosome complex subunit 1 isoform X12

      UniProtKB/TrEMBL
      B4DND6

    8. XM_054315838.1 → XP_054171813.1  COP9 signalosome complex subunit 1 isoform X3

      UniProtKB/TrEMBL
      B4DND6

    9. XM_054315841.1 → XP_054171816.1  COP9 signalosome complex subunit 1 isoform X6

      UniProtKB/TrEMBL
      B4DND6

    10. XM_054315849.1 → XP_054171824.1  COP9 signalosome complex subunit 1 isoform X14

      UniProtKB/TrEMBL
      B4DND6

    11. XM_054315855.1 → XP_054171830.1  COP9 signalosome complex subunit 1 isoform X20

      UniProtKB/TrEMBL
      B4DND6

    12. XM_054315862.1 → XP_054171837.1  COP9 signalosome complex subunit 1 isoform X1

      UniProtKB/TrEMBL
      B4DND6

    13. XM_054315863.1 → XP_054171838.1  COP9 signalosome complex subunit 1 isoform X2

      UniProtKB/TrEMBL
      B4DND6

    14. XM_054315867.1 → XP_054171842.1  COP9 signalosome complex subunit 1 isoform X12

      UniProtKB/TrEMBL
      B4DND6

    15. XM_054315865.1 → XP_054171840.1  COP9 signalosome complex subunit 1 isoform X3

      UniProtKB/TrEMBL
      B4DND6

    16. XM_054315839.1 → XP_054171814.1  COP9 signalosome complex subunit 1 isoform X4

      UniProtKB/TrEMBL
      B4DND6

    17. XM_054315840.1 → XP_054171815.1  COP9 signalosome complex subunit 1 isoform X5

      UniProtKB/TrEMBL
      B4DND6

    18. XM_054315843.1 → XP_054171818.1  COP9 signalosome complex subunit 1 isoform X8

      UniProtKB/TrEMBL
      B4DND6

    19. XM_054315845.1 → XP_054171820.1  COP9 signalosome complex subunit 1 isoform X10

      UniProtKB/TrEMBL
      B4DND6

    20. XM_054315842.1 → XP_054171817.1  COP9 signalosome complex subunit 1 isoform X7

      UniProtKB/TrEMBL
      B4DND6

    21. XM_054315848.1 → XP_054171823.1  COP9 signalosome complex subunit 1 isoform X13

      UniProtKB/TrEMBL
      B4DND6

    22. XM_054315850.1 → XP_054171825.1  COP9 signalosome complex subunit 1 isoform X15

      UniProtKB/TrEMBL
      B4DND6

    23. XM_054315844.1 → XP_054171819.1  COP9 signalosome complex subunit 1 isoform X9

      UniProtKB/TrEMBL
      B4DND6

    24. XM_054315852.1 → XP_054171827.1  COP9 signalosome complex subunit 1 isoform X17

      UniProtKB/TrEMBL
      B4DND6

    25. XM_054315853.1 → XP_054171828.1  COP9 signalosome complex subunit 1 isoform X18

      UniProtKB/TrEMBL
      B4DND6

    26. XM_054315861.1 → XP_054171836.1  COP9 signalosome complex subunit 1 isoform X1

      UniProtKB/TrEMBL
      B4DND6

    27. XM_054315864.1 → XP_054171839.1  COP9 signalosome complex subunit 1 isoform X3

      UniProtKB/TrEMBL
      B4DND6

    28. XM_054315866.1 → XP_054171841.1  COP9 signalosome complex subunit 1 isoform X6

      UniProtKB/TrEMBL
      B4DND6

    29. XM_054315857.1 → XP_054171832.1  COP9 signalosome complex subunit 1 isoform X22

      UniProtKB/TrEMBL
      B4DND6

    30. XM_054315858.1 → XP_054171833.1  COP9 signalosome complex subunit 1 isoform X23

      UniProtKB/TrEMBL
      B4DND6

    31. XM_054315859.1 → XP_054171834.1  COP9 signalosome complex subunit 1 isoform X24

      UniProtKB/TrEMBL
      B4DND6

    32. XM_054315860.1 → XP_054171835.1  COP9 signalosome complex subunit 1 isoform X25

      UniProtKB/TrEMBL
      B4DND6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13098.4 GenPept UniProtKB/Swiss-Prot:Q13098

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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