GPC4 glypican 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GPC4provided by HGNC
Official Full Name: glypican 4provided by HGNC
Primary source: HGNC:HGNC:4452
See related: Ensembl:ENSG00000076716 MIM:300168; AllianceGenome:HGNC:4452
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: KPTS; K-glypican
Summary: Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3' end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome. [provided by RefSeq, Jul 2008]
Expression: Broad expression in placenta (RPKM 22.5), kidney (RPKM 16.2) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: Xq26.2

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (133300103..133415489, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (131624867..131740250, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (132434131..132549517, complement)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Glypican-4 serum levels are associated with cognitive dysfunction and vascular risk factors in Parkinson's disease.
Title: Glypican-4 serum levels are associated with cognitive dysfunction and vascular risk factors in Parkinson's disease.
Circulating glypican-4 is a new predictor of all-cause mortality in patients with heart failure.
Title: Circulating glypican-4 is a new predictor of all-cause mortality in patients with heart failure.
The Shear Stress-Regulated Expression of Glypican-4 in Endothelial Dysfunction In Vitro and Its Clinical Significance in Atherosclerosis.
Title: The Shear Stress-Regulated Expression of Glypican-4 in Endothelial Dysfunction In Vitro and Its Clinical Significance in Atherosclerosis.
Serum glypican-4 is associated with the 10-year clinical outcome of patients with peripheral artery disease.
Title: Serum glypican-4 is associated with the 10-year clinical outcome of patients with peripheral artery disease.
Serum glypican-4 is a marker of future vascular risk and mortality in coronary angiography patients.
Title: Serum glypican-4 is a marker of future vascular risk and mortality in coronary angiography patients.
Downregulation of glypican-4 facilitates breast cancer progression by inducing cell migration and proliferation.
Title: Downregulation of glypican-4 facilitates breast cancer progression by inducing cell migration and proliferation.
The GPC4 gene polymorphism is associated with susceptibility to EBV-positive NPC. The CC genotype of GPC4 may represent a risk factor for NPC in Northern China.
Title: The Glypican-4 Gene Polymorphism rs1048369 and Susceptibility to Epstein-Barr Virus-Positive and -Negative Nasopharyngeal Carcinoma in Northern China.
Pathogenic variants in GPC4 gene are associated with Keipert Syndrome.
Title: Pathogenic Variants in GPC4 Cause Keipert Syndrome.
Results indicate a CD36-glypcian 4 (GPC4)-beta-catenin-c-myc signaling axis that regulates glycolysis in colorectal cancer (CRC) development and may provide an intervention strategy for CRC prevention.
Title: CD36 inhibits β-catenin/c-myc-mediated glycolysis through ubiquitination of GPC4 to repress colorectal tumorigenesis.
serum concentrations significantly increased in metabolic syndrome patients
Title: Serum Glypican 4 Levels Are Associated with Metabolic Syndrome in a Han Population from Guizhou Province, China.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Keipert syndrome MedGen: C1850627 OMIM: 301026 GeneReviews: Not available	Compare labs
Simpson-Golabi-Behmel syndrome type 1 MedGen: C0796154 OMIM: 312870 GeneReviews: Simpson-Golabi-Behmel Syndrome Type 1, Wilms Tumor Predisposition	Compare labs
Wilms tumor 1 MedGen: CN033288 OMIM: 194070 GeneReviews: Wilms Tumor Predisposition, PAX6-Related Aniridia, WT1 Disorder	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Glypican 4 (GPC4) is downregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells	PubMed
nucleocapsid	gag	Glypican 4 (GPC4) is downregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-D45526 (e-PCR)
- UniSTS:45588

WI-16817 (e-PCR)
- UniSTS:82712

AL032551 (e-PCR)
- UniSTS:93213

AL032600 (e-PCR)
- UniSTS:93270

SHGC-83545 (e-PCR)
- UniSTS:101751

AL023956 (e-PCR)
- UniSTS:74622

AF020112 (e-PCR)
- UniSTS:44937

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables coreceptor activity	NAS Non-traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of presynapse assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in synaptic membrane adhesion	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi lumen	TAS Traceable Author Statement more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in collagen-containing extracellular matrix	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in lysosomal lumen	TAS Traceable Author Statement more info
located_in nucleus	HDA more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: glypican-4

Names: dJ900E8.1 (glypican 4); glypican proteoglycan 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.