Phf20 PHD finger protein 20 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Phf20provided by MGI
Official Full Name: PHD finger protein 20provided by MGI
Primary source: MGI:MGI:2444148
See related: Ensembl:ENSMUSG00000038116 AllianceGenome:MGI:2444148
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 6820402O20Rik
Summary: Predicted to enable DNA binding activity and metal ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; nuclear membrane; and nucleoplasm. Predicted to be part of MLL1 complex and NSL complex. Is expressed in central nervous system; early conceptus; and genitourinary system. Orthologous to human PHF20 (PHD finger protein 20). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in cerebellum adult (RPKM 9.8), CNS E18 (RPKM 9.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H1; 2 77.38 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (156038567..156151873)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (156196647..156309953)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Yin Yang 1 is required for PHD finger protein 20-mediated myogenic differentiation in vitro and in vivo.
Title: Yin Yang 1 is required for PHD finger protein 20-mediated myogenic differentiation in vitro and in vivo.
PHF20 increased the enrichment of H3K4me3 on the promoter of Runx2 followed by increased Runx2 promoter activity.
Title: PHF20 positively regulates osteoblast differentiation via increasing the expression and activation of Runx2 with enrichment of H3K4me3.
PHF20 is not required for maintaining the global H4K16 acetylation levels or locus specific histone acetylation but instead works downstream in transcriptional regulation of MOF target genes
Title: Loss of the methyl lysine effector protein PHF20 impacts the expression of genes regulated by the lysine acetyltransferase MOF.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH68043 (e-PCR)
- UniSTS:19554

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

Phf20 (e-PCR), detects polymorphism
- UniSTS:527488

D1S3693 (e-PCR)
- UniSTS:474271

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of MLL1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of MLL1 complex	ISO Inferred from Sequence Orthology more info
part_of MLL1 complex	ISS Inferred from Sequence or Structural Similarity more info
part_of NSL complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NSL complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of histone acetyltransferase complex	ISO Inferred from Sequence Orthology more info
part_of histone acetyltransferase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: PHD finger protein 20

Names: hepatocellular carcinoma-associated antigen 58 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172674.2 → NP_766262.2 PHD finger protein 20

See identical proteins and their annotated locations for NP_766262.2

Status: VALIDATED

Source sequence(s)

AK033017, AK035209, AK045309, BC086753, CJ176261

Consensus CDS

CCDS38297.1

UniProtKB/Swiss-Prot

Q8BLG0, Q8BMA2, Q8BYR4, Q921N1

UniProtKB/TrEMBL

Q6PAR7

Related

ENSMUSP00000043138.9, ENSMUST00000037401.10

Conserved Domains (5) summary

cd04508
Location:90 → 135

TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...

cd15634
Location:657 → 700

PHD_PHF20; PHD finger found in PHD finger protein 20 (PHF20)

pfam12618
Location:176 → 259

DUF3776; Protein of unknown function (DUF3776)

cl17705
Location:3 → 68

MBT; mbt repeat

cl22934
Location:215 → 313

DUF1699; Protein of unknown function (DUF1699)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

156038567..156151873

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006499338.4 → XP_006499401.1 PHD finger protein 20 isoform X4

UniProtKB/TrEMBL

Q6PAR7

Conserved Domains (2) summary

cl17705
Location:3 → 68

MBT; mbt repeat

cl22851
Location:501 → 544

PHD_SF; PHD finger superfamily
XM_006499339.2 → XP_006499402.1 PHD finger protein 20 isoform X5

Conserved Domains (1) summary

cl22851
Location:251 → 294

PHD_SF; PHD finger superfamily
XM_036161523.1 → XP_036017416.1 PHD finger protein 20 isoform X5

Conserved Domains (1) summary

cl22851
Location:251 → 294

PHD_SF; PHD finger superfamily
XM_036161511.1 → XP_036017404.1 PHD finger protein 20 isoform X2

UniProtKB/TrEMBL

Q6PAR7

Conserved Domains (2) summary

pfam12618
Location:40 → 114

DUF3776; Protein of unknown function (DUF3776)

cl22851
Location:519 → 562

PHD_SF; PHD finger superfamily
XM_017317827.2 → XP_017173316.1 PHD finger protein 20 isoform X1

UniProtKB/TrEMBL

Q6PAR7

Conserved Domains (4) summary

cd15634
Location:602 → 645

PHD_PHF20; PHD finger found in PHD finger protein 20 (PHF20)

pfam05793
Location:74 → 259

TFIIF_alpha; Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)

pfam12618
Location:123 → 197

DUF3776; Protein of unknown function (DUF3776)

cl17705
Location:3 → 68

MBT; mbt repeat
XM_036161524.1 → XP_036017417.1 PHD finger protein 20 isoform X5

Conserved Domains (1) summary

cl22851
Location:251 → 294

PHD_SF; PHD finger superfamily
XM_036161513.1 → XP_036017406.1 PHD finger protein 20 isoform X2

UniProtKB/TrEMBL

Q6PAR7

Related

ENSMUST00000152617.8

Conserved Domains (2) summary

pfam12618
Location:40 → 114

DUF3776; Protein of unknown function (DUF3776)

cl22851
Location:519 → 562

PHD_SF; PHD finger superfamily
XM_036161514.1 → XP_036017407.1 PHD finger protein 20 isoform X2

UniProtKB/TrEMBL

Q6PAR7

Conserved Domains (2) summary

pfam12618
Location:40 → 114

DUF3776; Protein of unknown function (DUF3776)

cl22851
Location:519 → 562

PHD_SF; PHD finger superfamily
XM_036161515.1 → XP_036017408.1 PHD finger protein 20 isoform X3

UniProtKB/TrEMBL

Q6PAR7

Conserved Domains (2) summary

pfam12618
Location:39 → 113

DUF3776; Protein of unknown function (DUF3776)

cl22851
Location:518 → 561

PHD_SF; PHD finger superfamily