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    Ascc3 activating signal cointegrator 1 complex subunit 3 [ Mus musculus (house mouse) ]

    Gene ID: 77987, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ascc3provided by MGI
    Official Full Name
    activating signal cointegrator 1 complex subunit 3provided by MGI
    Primary source
    MGI:MGI:1925237
    See related
    Ensembl:ENSMUSG00000038774 AllianceGenome:MGI:1925237
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RNAH; Helic1; ASC1p200; D630041L21; B630009I04Rik; D430001L07Rik
    Summary
    Predicted to enable 3'-5' DNA helicase activity and ATP hydrolysis activity. Predicted to be involved in several processes, including DNA alkylation repair; rescue of stalled ribosome; and ribosome-associated ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Predicted to be part of DNA repair complex and activating signal cointegrator 1 complex. Predicted to be active in cytosolic ribosome and nucleus. Is expressed in embryo. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder. Orthologous to human ASCC3 (activating signal cointegrator 1 complex subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 4.7), liver E14 (RPKM 3.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ascc3 in Genome Data Viewer
    Location:
    10 B3; 10 24.87 cM
    Exon count:
    43
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (50468756..50727300)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (50592663..50851202)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57555 Neighboring gene predicted gene, 46199 Neighboring gene STARR-seq mESC enhancer starr_26642 Neighboring gene STARR-positive B cell enhancer ABC_E8333 Neighboring gene STARR-seq mESC enhancer starr_26643 Neighboring gene STARR-positive B cell enhancer mm9_chr10:50482908-50483208 Neighboring gene ribosomal protein L15 pseudogene Neighboring gene STARR-seq mESC enhancer starr_26645 Neighboring gene RIKEN cDNA A230054N11 gene Neighboring gene single-minded family bHLH transcription factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PEG3 control on the mammalian MSL complex. Ye A, et al. PLoS One, 2017. PMID 28609438, Free PMC Article
    2. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Latos PA, et al. Nat Commun, 2015 Jul 24. PMID 26206133, Free PMC Article
    3. Proteomic and yeast 2-hybrid screens to identify PTEN binding partners. Tibarewal P, et al. Adv Biol Regul, 2024 Jan. PMID 37839992
    4. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
    5. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-5' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3'-5' DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 3'-5' DNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP hydrolysis activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables forked DNA-dependent helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables four-way junction helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded 3'-5' DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA alkylation repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA alkylation repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in DNA duplex unwinding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA duplex unwinding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rescue of stalled ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rescue of stalled ribosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ribosome disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosome disassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ribosome-associated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosome-associated ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA repair complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of DNA repair complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of activating signal cointegrator 1 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of activating signal cointegrator 1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosolic ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    activating signal cointegrator 1 complex subunit 3
    Names
    helicase, ATP binding 1
    NP_932124.2
    XP_030101248.1
    XP_030101249.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198007.2 → NP_932124.2  activating signal cointegrator 1 complex subunit 3

      See identical proteins and their annotated locations for NP_932124.2

      Status: VALIDATED

      Source sequence(s)
      AC137877, AC153529, AC159114
      Consensus CDS
      CCDS48555.1
      UniProtKB/Swiss-Prot
      E9PZJ8, Q6PB36, Q8C1G1, Q8C707, Q8K292
      Related
      ENSMUSP00000036726.9, ENSMUST00000035606.10
      Conserved Domains (5) summary
      smart00490
      Location:1615 → 1694
      HELICc; helicase superfamily c-terminal domain
      smart00611
      Location:1810 → 2179
      SEC63; Domain of unknown function in Sec63p, Brr2p and other proteins
      COG1204
      Location:461 → 1240
      BRR2; Replicative superfamily II helicase [Replication, recombination and repair]
      pfam00270
      Location:1329 → 1500
      DEAD; DEAD/DEAH box helicase
      pfam02889
      Location:979 → 1287
      Sec63; Sec63 Brl domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      50468756..50727300
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245388.2 → XP_030101248.1  activating signal cointegrator 1 complex subunit 3 isoform X1

      Conserved Domains (3) summary
      COG1204
      Location:363 → 1142
      BRR2; Replicative superfamily II helicase [Replication, recombination and repair]
      cd18022
      Location:1229 → 1417
      DEXHc_ASCC3_2; C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3
      pfam18149
      Location:152 → 193
      Helicase_PWI; N-terminal helicase PWI domain

    2. XM_030245389.2 → XP_030101249.1  activating signal cointegrator 1 complex subunit 3 isoform X2

      Conserved Domains (2) summary
      COG1204
      Location:125 → 904
      BRR2; Replicative superfamily II helicase [Replication, recombination and repair]
      cd18022
      Location:991 → 1179
      DEXHc_ASCC3_2; C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9PZJ8.1 GenPept UniProtKB/Swiss-Prot:E9PZJ8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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