Xpo7 exportin 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Xpo7provided by MGI
Official Full Name: exportin 7provided by MGI
Primary source: MGI:MGI:1929705
See related: Ensembl:ENSMUSG00000022100 AllianceGenome:MGI:1929705
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: exp7; Ranbp16; 4930506C02Rik
Summary: Predicted to enable nuclear export signal receptor activity. Predicted to be involved in protein export from nucleus. Predicted to act upstream of or within nucleocytoplasmic transport. Predicted to be located in nucleus. Predicted to be part of nuclear pore. Predicted to be active in cytoplasm. Is expressed in heart and liver. Orthologous to human XPO7 (exportin 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in liver E14.5 (RPKM 28.1), liver E14 (RPKM 26.2) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D2; 14 36.44 cM

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (70899566..71004075, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (70662126..70770864, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The GWAS SNP rs80207740 modulates erythrocyte traits via allele-specific binding of IKZF1 and targeting XPO7 gene.
Title: The GWAS SNP rs80207740 modulates erythrocyte traits via allele-specific binding of IKZF1 and targeting XPO7 gene.
Exportin XPO7 acts as an oncogenic factor in prostate cancer via upregulation of TCF3.
Title: Exportin XPO7 acts as an oncogenic factor in prostate cancer via upregulation of TCF3.
An In Vivo Model for Elucidating the Role of an Erythroid-Specific Isoform of Nuclear Export Protein Exportin 7 (Xpo7) in Murine Erythropoiesis.
Title: An In Vivo Model for Elucidating the Role of an Erythroid-Specific Isoform of Nuclear Export Protein Exportin 7 (Xpo7) in Murine Erythropoiesis.
Xpo7 negatively regulates Hedgehog signaling by exporting Gli2 from the nucleus.
Title: Xpo7 negatively regulates Hedgehog signaling by exporting Gli2 from the nucleus.
Results found that XPO7 expression was significantly downregulated in the presence of the KLF1 Nan variant erythroid progenitors, potentially contributing to increased nuclear size.
Title: The mouse KLF1 Nan variant impairs nuclear condensation and erythroid maturation.
miR-181a is down-regulated during erythroid development and its expression inversely correlated with Xpo7 induction.
Title: miR-181a regulates erythroid enucleation via the regulation of Xpo7 expression.
Knockdown of Xpo7 in primary fetal liver erythroblasts resulted in severe inhibition of chromatin condensation and enucleation but otherwise had little effect on erythroid differentiation, including hemoglobin accumulation.
Title: Histones to the cytosol: exportin 7 is essential for normal terminal erythroid nuclear maturation.
This study demonstrateg that exportin-7 responds to ischemia in astrocytes.
Title: Astrocytic exportin-7 responds to ischemia through mediating LKB1 translocation from the nucleus to the cytoplasm.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Xpo7 (e-PCR), detects polymorphism
- UniSTS:531323

BB164534 (e-PCR)
- UniSTS:186009

RH129335 (e-PCR)
- UniSTS:212642

NoName (e-PCR)
- UniSTS:237222

D20S527E (e-PCR)
- UniSTS:150762

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables nuclear export signal receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear export signal receptor activity	IEA Inferred from Electronic Annotation more info
enables nuclear export signal receptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in nuclear export	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nucleocytoplasmic transport	TAS Traceable Author Statement more info	PubMed
involved_in protein export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein export from nucleus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
part_of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pore	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: exportin-7

Names: RAN binding protein 16; ran-binding protein 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359888.1 → NP_001346817.1 exportin-7 isoform 1

Status: VALIDATED

Source sequence(s)

AA051428, AI431041, AK036837, AK039776, AK143729

Consensus CDS

CCDS88710.1

UniProtKB/TrEMBL

A0A2I3BQV5, E9PUW7

Related

ENSMUSP00000154350.2, ENSMUST00000228346.2

Conserved Domains (2) summary

smart00913
Location:31 → 97

IBN_N; Importin-beta N-terminal domain

COG5101
Location:30 → 306

CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]
NM_023045.3 → NP_075532.1 exportin-7 isoform 2

See identical proteins and their annotated locations for NP_075532.1

Status: VALIDATED

Source sequence(s)

AA051428, AC125180, AI431041, AK036837, AK039776, AK164595, CA325231

Consensus CDS

CCDS36974.1

UniProtKB/Swiss-Prot

Q3TP94, Q80TS9, Q8BSK5, Q8C9M7, Q8CB42, Q8CBL8, Q8CEF5, Q9EPK7

UniProtKB/TrEMBL

E9PUW7

Related

ENSMUSP00000022696.7, ENSMUST00000022696.8

Conserved Domains (2) summary

smart00913
Location:30 → 96

IBN_N; Importin-beta N-terminal domain

COG5101
Location:29 → 305

CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

70899566..71004075 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030247914.2 → XP_030103774.1 exportin-7 isoform X2

UniProtKB/TrEMBL

E9PUW7

Related

ENSMUSP00000153855.2, ENSMUST00000226448.2

Conserved Domains (2) summary

smart00913
Location:30 → 96

IBN_N; Importin-beta N-terminal domain

COG5101
Location:29 → 314

CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]
XM_006519359.4 → XP_006519422.1 exportin-7 isoform X1

UniProtKB/TrEMBL

E9PUW7

Conserved Domains (2) summary

smart00913
Location:31 → 97

IBN_N; Importin-beta N-terminal domain

COG5101
Location:30 → 315

CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]
XM_011245132.4 → XP_011243434.1 exportin-7 isoform X3

UniProtKB/TrEMBL

E9PUW7

Conserved Domains (1) summary

pfam03810
Location:4 → 48

IBN_N; Importin-beta N-terminal domain