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    Rpusd4 RNA pseudouridylate synthase domain containing 4 [ Mus musculus (house mouse) ]

    Gene ID: 71989, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rpusd4provided by MGI
    Official Full Name
    RNA pseudouridylate synthase domain containing 4provided by MGI
    Primary source
    MGI:MGI:1919239
    See related
    Ensembl:ENSMUSG00000032044 AllianceGenome:MGI:1919239
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2410001E19Rik
    Summary
    Predicted to enable mitochondrial ribosomal large subunit rRNA binding activity; pseudouridine synthase activity; and tRNA binding activity. Predicted to be involved in mRNA pseudouridine synthesis; mitochondrial tRNA pseudouridine synthesis; and positive regulation of mitochondrial translation. Located in mitochondrion. Is expressed in genitourinary system. Orthologous to human RPUSD4 (RNA pseudouridine synthase D4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 8.8), limb E14.5 (RPKM 7.0) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rpusd4 in Genome Data Viewer
    Location:
    9 A4; 9 20.15 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (35179177..35187253)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (35267881..35275957)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5059 Neighboring gene FAD-dependent oxidoreductase domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_23764 Neighboring gene signal recognition particle receptor alpha Neighboring gene STARR-seq mESC enhancer starr_23765 Neighboring gene family with sequence similarity 118, member B Neighboring gene STARR-positive B cell enhancer ABC_E3823 Neighboring gene RIKEN cDNA 4933422A05 gene Neighboring gene STARR-positive B cell enhancer ABC_E10539 Neighboring gene ribosomal protein L36 pseudogene Neighboring gene predicted gene, 33838

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mitochondrial ribosomal large subunit rRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables mitochondrial ribosomal large subunit rRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables pseudouridine synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables tRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables tRNA pseudouridine synthase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA pseudouridine synthesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA pseudouridine synthesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrial tRNA pseudouridine synthesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitochondrial tRNA pseudouridine synthesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitochondrial translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitochondrial translation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in rRNA pseudouridine synthesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ribonucleoprotein granule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    pseudouridylate synthase RPUSD4, mitochondrial
    Names
    RNA pseudouridylate synthase domain-containing protein 4
    mitochondrial RNA pseudouridine synthase Rpusd4
    NP_082316.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028040.2NP_082316.1  pseudouridylate synthase RPUSD4, mitochondrial

      See identical proteins and their annotated locations for NP_082316.1

      Status: PROVISIONAL

      Source sequence(s)
      BC061256
      Consensus CDS
      CCDS22962.1
      UniProtKB/Swiss-Prot
      Q9CWX4
      Related
      ENSMUSP00000034543.5, ENSMUST00000034543.5
      Conserved Domains (2) summary
      TIGR00005
      Location:46347
      rluA_subfam; pseudouridine synthase, RluA family
      cd02869
      Location:106329
      PseudoU_synth_RluCD_like; Pseudouridine synthase, RsuA/RluD family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      35179177..35187253
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)