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    Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1 [ Mus musculus (house mouse) ]

    Gene ID: 22186, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Uba52provided by MGI
    Official Full Name
    ubiquitin A-52 residue ribosomal protein fusion product 1provided by MGI
    Primary source
    MGI:MGI:98887
    See related
    Ensembl:ENSMUSG00000090137 AllianceGenome:MGI:98887
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ubb; Ubc; Cep52; Gm1863; Rps27a; D8Ertd21e
    Summary
    A structural constituent of ribosome. Predicted to be involved in modification-dependent protein catabolic process and protein ubiquitination. Located in cytoplasm. Part of cytosolic large ribosomal subunit. Is active in synapse. Is expressed in optic vesicle. Orthologous to human UBA52 (ubiquitin A-52 residue ribosomal protein fusion product 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 805.6), colon adult (RPKM 792.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Uba52 in Genome Data Viewer
    Location:
    8 B3.3; 8 34.15 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (70960913..70963067, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70508263..70510417, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene cytokine receptor-like factor 1 Neighboring gene required for excision 1-B domain containing Neighboring gene RIKEN cDNA 4930522P08 gene Neighboring gene STARR-positive B cell enhancer ABC_E5013 Neighboring gene KxDL motif containing 1 Neighboring gene STARR-seq mESC enhancer starr_21774

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Immunocytochemical localization of ubiquitin A-52 protein in the mouse inner ear. Kitoh R, et al. Neuroreport, 2007 Jun 11. PMID 17515792
    2. Ubiquitin and the enigma of intracellular protein degradation. Jennissen HP. Eur J Biochem, 1995 Jul 1. PMID 7628459
    3. A novel mode of ubiquitin recognition by the ubiquitin-binding zinc finger domain of WRNIP1. Suzuki N, et al. FEBS J, 2016 Jun. PMID 27062441
    4. A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein. Chau V, et al. Science, 1989 Mar 24. PMID 2538923
    5. The ubiquitin hybrid gene UBA52 regulates ubiquitination of ribosome and sustains embryonic development. Kobayashi M, et al. Sci Rep, 2016 Nov 10. PMID 27829658, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. UBA52 Is Crucial in HSP90 Ubiquitylation and Neurodegenerative Signaling during Early Phase of Parkinson's Disease.
      Title: UBA52 Is Crucial in HSP90 Ubiquitylation and Neurodegenerative Signaling during Early Phase of Parkinson's Disease.
    2. UbA52 may have a functional role in regulation of ion secretion in the inner ear
      Title: Immunocytochemical localization of ubiquitin A-52 protein in the mouse inner ear.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107645

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein tag activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in modification-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation at postsynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in translation at presynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular anatomical structure IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in myelin sheath HDA PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in presynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in ribosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ubiquitin-ribosomal protein eL40 fusion protein
    Names
    60S ribosomal protein L40
    ubiquitin-60S ribosomal protein L40
    ubiquitin/60S ribosomal fusion protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001348227.1 → NP_001335156.1  ubiquitin-ribosomal protein eL40 fusion protein precursor

      Status: VALIDATED

      Source sequence(s)
      AA271295, AC157774, CK334428
      Consensus CDS
      CCDS22371.1
      UniProtKB/Swiss-Prot
      P62984, P62991, Q62317, Q64223, Q8VCH1, Q9CXY4, Q9CZM0, Q9D1R5, Q9D8D9, Q9ET23, Q9ET24, Q9Z0H9
      UniProtKB/TrEMBL
      Q5M9K3
      Related
      ENSMUSP00000080608.5, ENSMUST00000081940.11
      Conserved Domains (2) summary
      cd01803
      Location:1 → 76
      Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
      pfam01020
      Location:79 → 126
      Ribosomal_L40e; Ribosomal L40e family

    2. NM_001348228.1 → NP_001335157.1  ubiquitin-ribosomal protein eL40 fusion protein precursor

      Status: VALIDATED

      Source sequence(s)
      AA271295, AC157774, BQ746688
      Consensus CDS
      CCDS22371.1
      UniProtKB/Swiss-Prot
      P62984, P62991, Q62317, Q64223, Q8VCH1, Q9CXY4, Q9CZM0, Q9D1R5, Q9D8D9, Q9ET23, Q9ET24, Q9Z0H9
      UniProtKB/TrEMBL
      Q5M9K3
      Related
      ENSMUSP00000121149.2, ENSMUST00000129909.8
      Conserved Domains (2) summary
      cd01803
      Location:1 → 76
      Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
      pfam01020
      Location:79 → 126
      Ribosomal_L40e; Ribosomal L40e family

    3. NM_001348229.1 → NP_001335158.1  ubiquitin-ribosomal protein eL40 fusion protein precursor

      Status: VALIDATED

      Source sequence(s)
      AA271295, AC157774, BQ746688, EH108858
      Consensus CDS
      CCDS22371.1
      UniProtKB/Swiss-Prot
      P62984, P62991, Q62317, Q64223, Q8VCH1, Q9CXY4, Q9CZM0, Q9D1R5, Q9D8D9, Q9ET23, Q9ET24, Q9Z0H9
      UniProtKB/TrEMBL
      Q5M9K3
      Related
      ENSMUSP00000137461.2, ENSMUST00000165126.9
      Conserved Domains (2) summary
      cd01803
      Location:1 → 76
      Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
      pfam01020
      Location:79 → 126
      Ribosomal_L40e; Ribosomal L40e family

    4. NM_019883.4 → NP_063936.1  ubiquitin-ribosomal protein eL40 fusion protein precursor

      See identical proteins and their annotated locations for NP_063936.1

      Status: VALIDATED

      Source sequence(s)
      AA271295, AC157774, AK018726
      Consensus CDS
      CCDS22371.1
      UniProtKB/Swiss-Prot
      P62984, P62991, Q62317, Q64223, Q8VCH1, Q9CXY4, Q9CZM0, Q9D1R5, Q9D8D9, Q9ET23, Q9ET24, Q9Z0H9
      UniProtKB/TrEMBL
      Q5M9K3
      Related
      ENSMUSP00000120096.2, ENSMUST00000125184.8
      Conserved Domains (2) summary
      cd01803
      Location:1 → 76
      Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
      pfam01020
      Location:79 → 126
      Ribosomal_L40e; Ribosomal L40e family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      70960913..70963067 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62984.2 GenPept UniProtKB/Swiss-Prot:P62984

    Gene LinkOut

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