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    Dhx35 DEAH-box helicase 35 [ Mus musculus (house mouse) ]

    Gene ID: 71715, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dhx35provided by MGI
    Official Full Name
    DEAH-box helicase 35provided by MGI
    Primary source
    MGI:MGI:1918965
    See related
    Ensembl:ENSMUSG00000027655 AllianceGenome:MGI:1918965
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ddx35; 1200009D07Rik
    Summary
    Predicted to enable RNA binding activity and helicase activity. Acts upstream of or within in utero embryonic development. Predicted to be part of catalytic step 2 spliceosome. Orthologous to human DHX35 (DEAH-box helicase 35). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 5.7), whole brain E14.5 (RPKM 5.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dhx35 in Genome Data Viewer
    Location:
    2 H1; 2 78.74 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (158636674..158700141)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (158794745..158858220)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7879 Neighboring gene STARR-positive B cell enhancer mm9_chr2:158499319-158499620 Neighboring gene protein phosphatase 1, regulatory subunit 16B Neighboring gene STARR-positive B cell enhancer ABC_E2650 Neighboring gene STARR-positive B cell enhancer ABC_E7880 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:158548828-158549026 Neighboring gene STARR-positive B cell enhancer ABC_E2056 Neighboring gene STARR-positive B cell enhancer ABC_E7881 Neighboring gene STARR-positive B cell enhancer ABC_E416 Neighboring gene STARR-seq mESC enhancer starr_06234 Neighboring gene family with sequence similarity 83, member D Neighboring gene STARR-seq mESC enhancer starr_06235 Neighboring gene STARR-positive B cell enhancer ABC_E6010 Neighboring gene STARR-seq mESC enhancer starr_06237 Neighboring gene predicted gene, 38630 Neighboring gene STARR-seq mESC enhancer starr_06238 Neighboring gene STARR-seq mESC enhancer starr_06239 Neighboring gene STARR-seq mESC enhancer starr_06240 Neighboring gene STARR-seq mESC enhancer starr_06241 Neighboring gene predicted gene, 25090

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Knockout mice with pituitary malformations help identify human cases of hypopituitarism. Martinez-Mayer J, et al. Genome Med, 2024 May 31. PMID 38822427, Free PMC Article
    2. Highly variable penetrance of abnormal phenotypes in embryonic lethal knockout mice. Wilson R, et al. Wellcome Open Res, 2016. PMID 27996060, Free PMC Article
    3. Placentation defects are highly prevalent in embryonic lethal mouse mutants. Perez-Garcia V, et al. Nature, 2018 Mar 22. PMID 29539633, Free PMC Article
    4. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    probable ATP-dependent RNA helicase DHX35
    Names
    DEAH (Asp-Glu-Ala-His) box polypeptide 35
    NP_001278073.1
    NP_001359442.1
    NP_665685.1
    XP_006500253.1
    XP_030107952.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291144.2 → NP_001278073.1  probable ATP-dependent RNA helicase DHX35 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' region, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, and it also contains an additional in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AL669910
      Related
      ENSMUST00000145692.8
      Conserved Domains (5) summary
      smart00490
      Location:146 → 241
      HELICc; helicase superfamily c-terminal domain
      smart00847
      Location:310 → 394
      HA2; Helicase associated domain (HA2) Add an annotation
      COG1643
      Location:1 → 527
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      cd00046
      Location:1 → 56
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam07717
      Location:429 → 528
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

    2. NM_001372513.2 → NP_001359442.1  probable ATP-dependent RNA helicase DHX35 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL669910
      Consensus CDS
      CCDS89575.1
      UniProtKB/TrEMBL
      A2ACQ1
      Related
      ENSMUSP00000105104.3, ENSMUST00000109478.9
      Conserved Domains (1) summary
      COG1643
      Location:21 → 682
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

    3. NM_145742.3 → NP_665685.1  probable ATP-dependent RNA helicase DHX35 isoform a

      See identical proteins and their annotated locations for NP_665685.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (a).
      Source sequence(s)
      AL669910
      Consensus CDS
      CCDS16993.1
      UniProtKB/TrEMBL
      Q8K1G9
      Related
      ENSMUSP00000029186.8, ENSMUST00000029186.14
      Conserved Domains (5) summary
      smart00490
      Location:301 → 396
      HELICc; helicase superfamily c-terminal domain
      smart00487
      Location:53 → 224
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:465 → 549
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:73 → 211
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam07717
      Location:584 → 659
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      158636674..158700141
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500190.5 → XP_006500253.1  probable ATP-dependent RNA helicase DHX35 isoform X1

      Conserved Domains (1) summary
      COG1643
      Location:21 → 410
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

    2. XM_030252092.2 → XP_030107952.1  probable ATP-dependent RNA helicase DHX35 isoform X2

      Conserved Domains (1) summary
      COG1643
      Location:2 → 390
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

    RNA

    1. XR_003953722.2 RNA Sequence

    2. XR_004940734.1 RNA Sequence

    3. XR_004940735.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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