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    Cherp calcium homeostasis endoplasmic reticulum protein [ Mus musculus (house mouse) ]

    Gene ID: 27967, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cherpprovided by MGI
    Official Full Name
    calcium homeostasis endoplasmic reticulum proteinprovided by MGI
    Primary source
    MGI:MGI:106417
    See related
    Ensembl:ENSMUSG00000052488 AllianceGenome:MGI:106417
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DAN16; Scaf6; D8Wsu96e; 5730408I11Rik
    Summary
    Predicted to enable transmembrane transporter binding activity. Predicted to be involved in intracellular calcium ion homeostasis; positive regulation of calcineurin-NFAT signaling cascade; and release of sequestered calcium ion into cytosol. Predicted to act upstream of or within negative regulation of cell population proliferation. Predicted to be located in sarcoplasmic reticulum membrane. Predicted to be active in perinuclear region of cytoplasm. Is expressed in embryo and extraembryonic component. Orthologous to human CHERP (calcium homeostasis endoplasmic reticulum protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 40.1), limb E14.5 (RPKM 31.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cherp in Genome Data Viewer
    Location:
    8 B3.3; 8 35.08 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (73214327..73229077, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (72460483..72475233, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8247 Neighboring gene STARR-positive B cell enhancer ABC_E9731 Neighboring gene epidermal growth factor receptor pathway substrate 15-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E5020 Neighboring gene predicted gene, 46043 Neighboring gene RIKEN cDNA 1700030K09 gene Neighboring gene STARR-positive B cell enhancer ABC_E359 Neighboring gene calreticulin 3 Neighboring gene STARR-positive B cell enhancer ABC_E6662 Neighboring gene microRNA 7068 Neighboring gene solute carrier family 35, member E1 Neighboring gene STARR-positive B cell enhancer ABC_E2267 Neighboring gene uncharacterized LOC102639683 Neighboring gene mediator complex subunit 26

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genomic characterization of the lysophosphatidic acid receptor gene, lp(A2)/Edg4, and identification of a frameshift mutation in a previously characterized cDNA. Contos JJ, et al. Genomics, 2000 Mar 1. PMID 10729222
    2. Mammalian splicing factor SF1 interacts with SURP domains of U2 snRNP-associated proteins. Crisci A, et al. Nucleic Acids Res, 2015 Dec 2. PMID 26420826, Free PMC Article
    3. Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras. Wang T, et al. Cell, 2017 Feb 23. PMID 28162770, Free PMC Article
    4. Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor. Pilot-Storck F, et al. Mol Cell Proteomics, 2010 Jul. PMID 20368287, Free PMC Article
    5. Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Ko MS, et al. Hum Mol Genet, 1998 Nov. PMID 9811942

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within intracellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of calcineurin-NFAT signaling cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sarcoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    calcium homeostasis endoplasmic reticulum protein
    Names
    SR-related CTD associated factor 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359024.1 → NP_001345953.1  calcium homeostasis endoplasmic reticulum protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC113182
      Consensus CDS
      CCDS90417.1
      UniProtKB/Swiss-Prot
      Q8CGZ0, Q8K291, Q8VCD2
      UniProtKB/TrEMBL
      G5E8I8
      Related
      ENSMUSP00000078469.6, ENSMUST00000079510.6
      Conserved Domains (5) summary
      smart00443
      Location:861 → 911
      G_patch; glycine rich nucleic binding domain
      smart00648
      Location:13 → 65
      SWAP; Suppressor-of-White-APricot splicing regulator
      pfam04818
      Location:211 → 284
      CTD_bind; RNA polymerase II-binding domain
      cl25764
      Location:528 → 666
      PAT1; Topoisomerase II-associated protein PAT1
      cl27975
      Location:393 → 702
      EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)

    2. NM_138585.3 → NP_613051.3  calcium homeostasis endoplasmic reticulum protein isoform 1

      See identical proteins and their annotated locations for NP_613051.3

      Status: VALIDATED

      Source sequence(s)
      AF536541, AK049765, BY061354
      Consensus CDS
      CCDS40389.1
      UniProtKB/Swiss-Prot
      Q8CGZ0, Q8K291, Q8VCD2
      UniProtKB/TrEMBL
      A0A1D5RL92
      Related
      ENSMUSP00000148273.2, ENSMUST00000212991.2
      Conserved Domains (3) summary
      smart00443
      Location:850 → 900
      G_patch; glycine rich nucleic binding domain
      smart00648
      Location:13 → 65
      SWAP; Suppressor-of-White-APricot splicing regulator
      pfam04818
      Location:212 → 271
      CTD_bind; RNA polymerase II-binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      73214327..73229077 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CGZ0.1 GenPept UniProtKB/Swiss-Prot:Q8CGZ0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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