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    Nup133 nucleoporin 133 [ Mus musculus (house mouse) ]

    Gene ID: 234865, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Nup133provided by MGI
    Official Full Name
    nucleoporin 133provided by MGI
    Primary source
    MGI:MGI:2442620
    See related
    Ensembl:ENSMUSG00000039509 AllianceGenome:MGI:2442620
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mermaid
    Summary
    Predicted to be a structural constituent of nuclear pore. Acts upstream of or within nervous system development; paraxial mesoderm development; and somite development. Part of nuclear pore. Is expressed in several structures, including brain; epiblast; male reproductive gland or organ; neural tube; and paraxial mesenchyme. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome and nephrotic syndrome type 18. Orthologous to human NUP133 (nucleoporin 133). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 8.3), liver E14.5 (RPKM 8.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nup133 in Genome Data Viewer
    Location:
    8 E2; 8 72.27 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (124623862..124676019, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (123897114..123949265, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53468 Neighboring gene predicted gene, 29773 Neighboring gene actin alpha 1, skeletal muscle Neighboring gene ATP-binding cassette, sub-family B member 10 Neighboring gene predicted gene, 53469 Neighboring gene STARR-seq mESC enhancer starr_22990 Neighboring gene TATA-box binding protein associated factor 5 like Neighboring gene ribosomal protein L7A pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A Nup133-dependent NPC-anchored network tethers centrosomes to the nuclear envelope in prophase. Bolhy S, et al. J Cell Biol, 2011 Mar 7. PMID 21383080, Free PMC Article
    2. Nup133 Is Required for Proper Nuclear Pore Basket Assembly and Dynamics in Embryonic Stem Cells. Souquet B, et al. Cell Rep, 2018 May 22. PMID 29791854, Free PMC Article
    3. Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export. Vasu S, et al. J Cell Biol, 2001 Oct 29. PMID 11684705, Free PMC Article
    4. An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells. Belgareh N, et al. J Cell Biol, 2001 Sep 17. PMID 11564755, Free PMC Article
    5. Peering through the pore: nuclear pore complex structure, assembly, and function. Suntharalingam M, et al. Dev Cell, 2003 Jun. PMID 12791264

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nup133 is dispensable for interphase and postmitotic nuclear pore complex scaffold assembly in pluripotent mouse embryonic stem cell.
      Title: Nup133 Is Required for Proper Nuclear Pore Basket Assembly and Dynamics in Embryonic Stem Cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables structural constituent of nuclear pore ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA export from nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in nephron development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nephron development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within neural tube development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear pore organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear pore organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleocytoplasmic transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within paraxial mesoderm development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in poly(A)+ mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within somite development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear pore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear pore ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of nuclear pore NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of nuclear pore outer ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear pore outer ring ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear pore outer ring ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    nuclear pore complex protein Nup133
    Names
    133 kDa nucleoporin
    nucleoporin Nup133

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172288.3 → NP_758492.2  nuclear pore complex protein Nup133

      See identical proteins and their annotated locations for NP_758492.2

      Status: VALIDATED

      Source sequence(s)
      AC123825, AC147266
      Consensus CDS
      CCDS22765.1
      UniProtKB/Swiss-Prot
      E9QLJ8, Q8R0G9
      UniProtKB/TrEMBL
      Q8CDZ5
      Related
      ENSMUSP00000048084.8, ENSMUST00000044795.8
      Conserved Domains (1) summary
      pfam03177
      Location:594 → 1097
      Nucleoporin_C; Non-repetitive/WGA-negative nucleoporin C-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      124623862..124676019 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530964.5 → XP_006531027.1  nuclear pore complex protein Nup133 isoform X1

      Conserved Domains (1) summary
      pfam03177
      Location:184 → 454
      Nucleoporin_C; Non-repetitive/WGA-negative nucleoporin C-terminal
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R0G9.2 GenPept UniProtKB/Swiss-Prot:Q8R0G9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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