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    Krtap12-1 keratin associated protein 12-1 [ Mus musculus (house mouse) ]

    Gene ID: 16694, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Krtap12-1provided by MGI
    Official Full Name
    keratin associated protein 12-1provided by MGI
    Primary source
    MGI:MGI:1328315
    See related
    Ensembl:ENSMUSG00000069583 AllianceGenome:MGI:1328315
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D10Jhu14e
    Summary
    Predicted to enable identical protein binding activity. Predicted to be located in cytosol and keratin filament. Is expressed in several structures, including alimentary system; integumental system; limb; nervous system; and sensory organ. Orthologous to several human genes including KRTAP12-2 (keratin associated protein 12-2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See Krtap12-1 in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (77556420..77557090)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (77720586..77721256)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene thrombospondin type laminin G domain and EAR repeats Neighboring gene keratin associated protein 12-22 Neighboring gene keratin associated protein 12-21 Neighboring gene keratin associated protein 12-20 Neighboring gene keratin associated protein 12-24

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A cluster of keratin-associated proteins on mouse chromosome 10 in the region of conserved linkage with human chromosome 21. Cole SE, et al. Genomics, 1998 Dec 15. PMID 9878246
    2. The disruption of Sox21-mediated hair shaft cuticle differentiation causes cyclic alopecia in mice. Kiso M, et al. Proc Natl Acad Sci U S A, 2009 Jun 9. PMID 19470461, Free PMC Article
    3. High-resolution comparative physical mapping of mouse chromosome 10 in the region of homology with human chromosome 21. Cole SE, et al. Mamm Genome, 1999 Mar. PMID 10051316
    4. Molecular evolution of the keratin associated protein gene family in mammals, role in the evolution of mammalian hair. Wu DD, et al. BMC Evol Biol, 2008 Aug 23. PMID 18721477, Free PMC Article
    5. Perfect conserved linkage across the entire mouse chromosome 10 region homologous to human chromosome 21. Wiltshire T, et al. Genome Res, 1999 Dec. PMID 10613844, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Clone Names

    • MGC130277, MGC130278

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in keratin filament IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    keratin-associated protein 12-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010670.1 → NP_034800.1  keratin-associated protein 12-1

      Status: VALIDATED

      Source sequence(s)
      AF081797
      Consensus CDS
      CCDS23959.1
      UniProtKB/Swiss-Prot
      Q9Z287
      Related
      ENSMUSP00000090024.2, ENSMUST00000092370.3
      Conserved Domains (1) summary
      pfam13885
      Location:69 → 113
      Keratin_B2_2; Keratin, high sulfur B2 protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      77556420..77557090
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z287.1 GenPept UniProtKB/Swiss-Prot:Q9Z287

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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