Mrc1 mannose receptor, C type 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mrc1provided by MGI
Official Full Name: mannose receptor, C type 1provided by MGI
Primary source: MGI:MGI:97142
See related: Ensembl:ENSMUSG00000026712 AllianceGenome:MGI:97142
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MR; CD206
Summary: Enables D-mannose binding activity and transmembrane signaling receptor activity. Acts upstream of or within cellular response to interleukin-4; cellular response to lipopolysaccharide; and cellular response to type II interferon. Located in cell surface. Is expressed in several structures, including hemolymphoid system; intestine; liver; lung; and yolk sac. Orthologous to human MRC1 (mannose receptor C-type 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in bladder adult (RPKM 7.7), placenta adult (RPKM 4.9) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A2; 2 10.46 cM

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (14234225..14336834)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (14229414..14332023)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

N-glycosylation of mannose receptor (CD206) regulates glycan binding by C-type lectin domains.
Title: N-glycosylation of mannose receptor (CD206) regulates glycan binding by C-type lectin domains.
The GRP94 Inhibitor PU-WS13 Decreases M2-like Macrophages in Murine TNBC Tumors: A Pharmaco-Imaging Study with (99m)Tc-Tilmanocept SPECT.
Title: The GRP94 Inhibitor PU-WS13 Decreases M2-like Macrophages in Murine TNBC Tumors: A Pharmaco-Imaging Study with (99m)Tc-Tilmanocept SPECT.
Reduced TGF-beta Expression and CD206-Positive Resident Macrophages in the Intervertebral Discs of Aged Mice.
Title: Reduced TGF-β Expression and CD206-Positive Resident Macrophages in the Intervertebral Discs of Aged Mice.
CD206+ M2-Like Macrophages Are Essential for Successful Implantation.
Title: CD206+ M2-Like Macrophages Are Essential for Successful Implantation.
These studies support a critical but previously unrecognized role of MRC1 and miR-511-3p in protection against allergen-induced lung inflammation.
Title: Mannose receptor modulates macrophage polarization and allergic inflammation through miR-511-3p.
reduced bacterial loads occur in the airways of MRC-1-deficient mice and in mice in which MRC-1 is inhibited using blocking antibodies.
Title: Pneumolysin binds to the mannose receptor C type 1 (MRC-1) leading to anti-inflammatory responses and enhanced pneumococcal survival.
These results show that MR protects against a pathogenic inflammatory macrophage response induced by mannan and is associated with induction of ROS.
Title: The Macrophage Mannose Receptor Regulate Mannan-Induced Psoriasis, Psoriatic Arthritis, and Rheumatoid Arthritis-Like Disease Models.
findings show that TLR6 and mannose receptor participate as macrophage receptors for Mycobacterium lepraemurium
Title: Mycobacterium lepraemurium uses TLR-6 and MR, but not lipid rafts or DC-sign, to gain access into mouse macrophages.
current study shows that Mrc1-/- mice develop less severe dextran sulfate sodium-induced colitis
Title: miR-511-3p, embedded in the macrophage mannose receptor gene, contributes to intestinal inflammation.
the key roles of the ManR and ASGR in controlling circulating levels of numerous glycoproteins critical for regulating reproductive hormones and blood coagulation.
Title: Functional Consequences of Mannose and Asialoglycoprotein Receptor Ablation.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW259686 (e-PCR)
- UniSTS:178576

Z11974 (e-PCR)
- UniSTS:163275

Z11974 (e-PCR)
- UniSTS:125913

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables D-mannose binding	IDA Inferred from Direct Assay more info	PubMed
enables cargo receptor activity	ISO Inferred from Sequence Orthology more info
enables cargo receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to interleukin-4	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to type II interferon	IDA Inferred from Direct Assay more info	PubMed
involved_in receptor-mediated endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in receptor-mediated endocytosis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: macrophage mannose receptor 1

Names: MMR

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008625.2 → NP_032651.2 macrophage mannose receptor 1 precursor

See identical proteins and their annotated locations for NP_032651.2

Status: VALIDATED

Source sequence(s)

AK079897, AL845290, BE197931, Z11974

Consensus CDS

CCDS15700.1

UniProtKB/Swiss-Prot

Q61830, Q8C502

UniProtKB/TrEMBL

Q2HZ94

Related

ENSMUSP00000028045.3, ENSMUST00000028045.4

Conserved Domains (5) summary

smart00059
Location:161 → 209

FN2; Fibronectin type 2 domain

cd00037
Location:659 → 779

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

smart00034
Location:362 → 487

CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)

smart00458
Location:27 → 142

RICIN; Ricin-type beta-trefoil

cd00161
Location:34 → 140

RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...