Jdp2 Jun dimerization protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Jdp2provided by MGI
Official Full Name: Jun dimerization protein 2provided by MGI
Primary source: MGI:MGI:1932093
See related: Ensembl:ENSMUSG00000034271 AllianceGenome:MGI:1932093
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TIF; Jundm2; Jundp2
Summary: Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; cAMP response element binding activity; and protein dimerization activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within with a negative effect on regulation of transcription by RNA polymerase II. Acts upstream of or within chromatin remodeling and negative regulation of fat cell differentiation. Located in nucleus. Is expressed in several structures, including blood island; central nervous system; genitourinary system; musculoskeletal system; and neural retina. Orthologous to human JDP2 (Jun dimerization protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 10.5), limb E14.5 (RPKM 9.3) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 D2; 12 39.74 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (85645190..85686652)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (85598656..85639878)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structural, Pro-Inflammatory and Calcium Handling Remodeling Underlies Spontaneous Onset of Paroxysmal Atrial Fibrillation in JDP2-Overexpressing Mice.
Title: Structural, Pro-Inflammatory and Calcium Handling Remodeling Underlies Spontaneous Onset of Paroxysmal Atrial Fibrillation in JDP2-Overexpressing Mice.
Transgenic mice with cardiac expression of either JDP2 or ATF3 showed maladaptive remodeling and cardiac dysfunction. Surprisingly, JDP2 knockout (KO) did not protect the heart following transverse aortic constriction. Instead, the JDP2 KO mice performed worse than their wild type counterparts.
Title: JDP2 and ATF3 deficiencies dampen maladaptive cardiac remodeling and preserve cardiac function.
JDP2 regulates the expression of essential tumor promoting factors, such as Sdf1 expressed by cancer associated fibroblasts within the tumor microenvironment, and thus restrain tumor growth.
Title: ATF3 and JDP2 deficiency in cancer associated fibroblasts promotes tumor growth via SDF-1 transcription.
JDP2 overexpression is associated with heart failure development.
Title: JDP2 overexpression provokes cardiac dysfunction in mice.
JDP2 role in the traumatic brain injury and cognitive function.JDP2 promoted caspase-3 activation in astrocytes.
Title: Deletion of JDP2 improves neurological outcomes of traumatic brain injury (TBI) in mice: Inactivation of Caspase-3.
Female JDP2 null mice, however, exhibited early puberty, observed as early vaginal opening, larger litters, and early reproductive senescence. JDP2 null females had increased levels of circulating FSH and higher expression of the Fshb subunit in the pituitary, resulting in elevated serum estrogen and higher numbers of large ovarian follicles
Title: c-JUN Dimerization Protein 2 (JDP2) Is a Transcriptional Repressor of Follicle-stimulating Hormone β (FSHβ) and Is Required for Preventing Premature Reproductive Senescence in Female Mice.
JDP2 acts as a novel transcriptional activator of the mouse Mc2r gene, suggesting that JDP2 may have physiological functions as a novel player in MC2R-mediated steroidogenesis as well as cell signaling in adrenal glands.
Title: Jun Dimerization Protein 2 Activates Mc2r Transcriptional Activity: Role of Phosphorylation and SUMOylation.
High JDP2 expression in the bone marrow contributes to metastatic spread in the lung.
Title: Host JDP2 expression in the bone marrow contributes to metastatic spread.
results suggest a negative feedback loop between JDP2 and p53, and a direct link between JDP2 and a key oncogenic pathway
Title: Cloning and characterization of the mouse JDP2 gene promoter reveal negative regulation by p53.
Tbx3 plays an important role in osteoclastogenesis at least in part by regulating CSF1-dependent expression of JDP2.
Title: The transcription factor T-box 3 regulates colony-stimulating factor 1-dependent Jun dimerization protein 2 expression and plays an important role in osteoclastogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables cAMP response element binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables histone chaperone activity	IGI Inferred from Genetic Interaction more info	PubMed
enables histone deacetylase binding	IPI Inferred from Physical Interaction more info	PubMed
enables leucine zipper domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin remodeling	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within_negative_effect regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: jun dimerization protein 2

Names: c-Jun dimerization protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001205052.2 → NP_001191981.1 jun dimerization protein 2

See identical proteins and their annotated locations for NP_001191981.1

Status: VALIDATED

Source sequence(s)

AC115037

Consensus CDS

CCDS26060.1

UniProtKB/Swiss-Prot

P97875

UniProtKB/TrEMBL

Q9EQX5

Related

ENSMUSP00000136823.2, ENSMUST00000177587.9

Conserved Domains (3) summary

cd14686
Location:82 → 132

bZIP; coiled coil [structural motif]

cl21453
Location:18 → 61

PKc_like; Protein Kinases, catalytic domain

cl21462
Location:82 → 135

bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
NM_001205053.2 → NP_001191982.1 jun dimerization protein 2

See identical proteins and their annotated locations for NP_001191982.1

Status: VALIDATED

Source sequence(s)

AC115037

Consensus CDS

CCDS26060.1

UniProtKB/Swiss-Prot

P97875

UniProtKB/TrEMBL

Q9EQX5

Related

ENSMUSP00000129985.3, ENSMUST00000171754.3

Conserved Domains (3) summary

cd14686
Location:82 → 132

bZIP; coiled coil [structural motif]

cl21453
Location:18 → 61

PKc_like; Protein Kinases, catalytic domain

cl21462
Location:82 → 135

bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
NM_001401266.1 → NP_001388195.1 jun dimerization protein 2

Status: VALIDATED

Source sequence(s)

AC115037

UniProtKB/Swiss-Prot

P97875
NM_030887.3 → NP_112149.2 jun dimerization protein 2

See identical proteins and their annotated locations for NP_112149.2

Status: VALIDATED

Source sequence(s)

AC115037

Consensus CDS

CCDS26060.1

UniProtKB/Swiss-Prot

P97875

UniProtKB/TrEMBL

Q9EQX5

Related

ENSMUSP00000059724.7, ENSMUST00000050687.14

Conserved Domains (3) summary

cd14686
Location:82 → 132

bZIP; coiled coil [structural motif]

cl21453
Location:18 → 61

PKc_like; Protein Kinases, catalytic domain

cl21462
Location:82 → 135

bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

85645190..85686652

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011244218.2 → XP_011242520.1 jun dimerization protein 2 isoform X1

Conserved Domains (2) summary

cd14722
Location:205 → 258

bZIP_ATF3; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-3 (ATF-3) and similar proteins: a DNA-binding and dimerization domain

cl21453
Location:128 → 171

PKc_like; Protein Kinases, catalytic domain
XM_036157688.1 → XP_036013581.1 jun dimerization protein 2 isoform X2

Conserved Domains (1) summary

cl21453
Location:128 → 171

PKc_like; Protein Kinases, catalytic domain