P2ry2 purinergic receptor P2Y, G-protein coupled 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: P2ry2provided by MGI
Official Full Name: purinergic receptor P2Y, G-protein coupled 2provided by MGI
Primary source: MGI:MGI:105107
See related: Ensembl:ENSMUSG00000032860 AllianceGenome:MGI:105107
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: P2U1; P2Y2
Summary: Predicted to enable A1 adenosine receptor binding activity; ATP binding activity; and G protein-coupled UTP receptor activity. Acts upstream of or within positive regulation of mucus secretion. Predicted to be located in apical plasma membrane; basolateral plasma membrane; and early endosome. Predicted to be active in glutamatergic synapse and presynaptic active zone membrane. Is expressed in lung. Orthologous to human P2RY2 (purinergic receptor P2Y2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in heart adult (RPKM 12.3), small intestine adult (RPKM 10.9) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E2; 7 54.47 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (100645775..100661260, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (100996568..101012053, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Purinergic signaling through the P2Y2 receptor regulates osteocytes' mechanosensitivity.
Title: Purinergic signaling through the P2Y2 receptor regulates osteocytes' mechanosensitivity.
P2Y2 purinergic receptor gene deletion protects mice from bacterial endotoxin and sepsis-associated liver injury and mortality.
Title: P2Y2 purinergic receptor gene deletion protects mice from bacterial endotoxin and sepsis-associated liver injury and mortality.
The P2Y2 receptor mediates terminal adipocyte differentiation and insulin resistance: Evidence for a dual G-protein coupling mode.
Title: The P2Y(2) receptor mediates terminal adipocyte differentiation and insulin resistance: Evidence for a dual G-protein coupling mode.
P2Y2-P2X7 receptors cross-talk in primed mesenteric endothelial cells upregulates NF-kappaB signaling favoring mononuclear cell adhesion in schistosomiasis.
Title: P2Y(2)-P2X7 receptors cross-talk in primed mesenteric endothelial cells upregulates NF-κB signaling favoring mononuclear cell adhesion in schistosomiasis.
P2Y2 receptor decreases blood pressure by inhibiting ENaC.
Title: P2Y2 receptor decreases blood pressure by inhibiting ENaC.
Deletion of the P2Y2 receptor aggravates internal elastic lamina calcification in chronic kidney disease mice through upregulation of alkaline phosphatase and lipocalin-2.
Title: Deletion of the P2Y(2) receptor aggravates internal elastic lamina calcification in chronic kidney disease mice through upregulation of alkaline phosphatase and lipocalin-2.
Astrocyte-mediated purinergic signaling is upregulated in a mouse model of Fragile X syndrome.
Title: Astrocyte-mediated purinergic signaling is upregulated in a mouse model of Fragile X syndrome.
Blastocyst-induced ATP release from luminal epithelial cells initiates decidualization through the P2Y2 receptor in mice.
Title: Blastocyst-induced ATP release from luminal epithelial cells initiates decidualization through the P2Y2 receptor in mice.
P2Y2R contributes to the development of diabetic nephropathy by inhibiting autophagy response.
Title: P2Y2R contributes to the development of diabetic nephropathy by inhibiting autophagy response.
P2Y2 promotes fibroblasts activation and skeletal muscle fibrosis through AKT, ERK, and PKC.
Title: P2Y2 promotes fibroblasts activation and skeletal muscle fibrosis through AKT, ERK, and PKC.

Submit: New GeneRIF Correction See all GeneRIFs (87)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (5) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables A1 adenosine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables A1 adenosine receptor binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables G protein-coupled UTP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled UTP receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled purinergic nucleotide receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled purinergic nucleotide receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in blood vessel diameter maintenance	IEA Inferred from Electronic Annotation more info
involved_in blood vessel diameter maintenance	ISO Inferred from Sequence Orthology more info
acts_upstream_of establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of mucus secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of ossification	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of chemokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of mucus secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of penile erection	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of prostaglandin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of presynaptic cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic vesicle exocytosis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: P2Y purinoceptor 2

Names: ATP receptor; P2U purinoceptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001302346.1 → NP_001289275.1 P2Y purinoceptor 2

See identical proteins and their annotated locations for NP_001289275.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AC151414, AK005013

Consensus CDS

CCDS21508.1

UniProtKB/Swiss-Prot

O09031, P35383, Q9CPZ4

UniProtKB/TrEMBL

A0A0R4J289

Related

ENSMUSP00000146352.2, ENSMUST00000207916.2

Conserved Domains (1) summary

pfam00001
Location:51 → 306

7tm_1; 7 transmembrane receptor (rhodopsin family)
NM_001302347.1 → NP_001289276.1 P2Y purinoceptor 2

See identical proteins and their annotated locations for NP_001289276.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AC151414, AK005013, AK017378

Consensus CDS

CCDS21508.1

UniProtKB/Swiss-Prot

O09031, P35383, Q9CPZ4

UniProtKB/TrEMBL

A0A0R4J289

Related

ENSMUSP00000137152.2, ENSMUST00000178340.3

Conserved Domains (1) summary

pfam00001
Location:51 → 306

7tm_1; 7 transmembrane receptor (rhodopsin family)
NM_008773.4 → NP_032799.2 P2Y purinoceptor 2

See identical proteins and their annotated locations for NP_032799.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AC151414, AK005013, AK017378

Consensus CDS

CCDS21508.1

UniProtKB/Swiss-Prot

O09031, P35383, Q9CPZ4

UniProtKB/TrEMBL

A0A0R4J289

Related

ENSMUSP00000036765.4, ENSMUST00000037540.5

Conserved Domains (1) summary

pfam00001
Location:51 → 306

7tm_1; 7 transmembrane receptor (rhodopsin family)