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    Zfx zinc finger protein X-linked [ Mus musculus (house mouse) ]

    Gene ID: 22764, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfxprovided by MGI
    Official Full Name
    zinc finger protein X-linkedprovided by MGI
    Primary source
    MGI:MGI:99211
    See related
    Ensembl:ENSMUSG00000079509 AllianceGenome:MGI:99211
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zfx5; Zfx6; Zfx5,6
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin insulator sequence binding activity. Acts upstream of or within several processes, including oocyte development; ovarian follicle development; and parental behavior. Predicted to be located in chromatin; nucleolus; and nucleoplasm. Predicted to be active in chromosome. Is expressed in several structures, including 4-cell stage embryo; central nervous system; genitourinary system; ileum; and spleen. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability. Orthologous to human ZFX (zinc finger protein X-linked). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 7.9), CNS E11.5 (RPKM 4.7) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfx in Genome Data Viewer
    Location:
    X C3; X 41.48 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (93118237..93194250, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (94074631..94150645, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene 15165 Neighboring gene STARR-seq mESC enhancer starr_47553 Neighboring gene predicted pseudogene 6987 Neighboring gene STARR-seq mESC enhancer starr_47554 Neighboring gene STARR-seq mESC enhancer starr_47555 Neighboring gene predicted gene, 46691 Neighboring gene STARR-seq mESC enhancer starr_47557 Neighboring gene eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked Neighboring gene STARR-seq mESC enhancer starr_47559 Neighboring gene STARR-positive B cell enhancer ABC_E8763 Neighboring gene kelch-like 15 Neighboring gene microRNA 7673

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. [Expression of Zfx in mouse testicular spermatogenic cells]. Wang XZ, et al. Zhonghua Nan Ke Xue, 2023 May. PMID 38602753
    2. Evolution of the Zfx and Zfy genes: rates and interdependence between the genes. Pamilo P, et al. Mol Biol Evol, 1993 Mar. PMID 8487630
    3. The structure of the Zfx gene on the mouse X chromosome. Luoh SW, et al. Genomics, 1994 Jan 15. PMID 8188262
    4. Transcription factor Zfx controls BCR-induced proliferation and survival of B lymphocytes. Arenzana TL, et al. Blood, 2009 Jun 4. PMID 19329779, Free PMC Article
    5. Blockade of ZFX Alleviates Hypoxia-Induced Pulmonary Vascular Remodeling by Regulating the YAP Signaling. Tang L, et al. Cardiovasc Toxicol, 2024 Feb. PMID 38310188

    See all (81) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. [Expression of Zfx in mouse testicular spermatogenic cells].
      Title: [Expression of Zfx in mouse testicular spermatogenic cells].
    2. Blockade of ZFX Alleviates Hypoxia-Induced Pulmonary Vascular Remodeling by Regulating the YAP Signaling.
      Title: Blockade of ZFX Alleviates Hypoxia-Induced Pulmonary Vascular Remodeling by Regulating the YAP Signaling.
    3. Circ_0000520 contributes to triple-negative breast cancer progression through mediating the miR-1296/ZFX axis.
      Title: Circ_0000520 contributes to triple-negative breast cancer progression through mediating the miR-1296/ZFX axis.
    4. our findings show that RNAi-mediated disruption of Zfx/Zfy in mouse testis affected X/Y spermatogenesis. Additionally, results suggest that the paralogous genes Zfx/Zfy play an important role in the process of X and Y sperm development. The individual interference of Zfx/Zfy may predict the outcome of X and Y haploid sperms. Presented herein is an advanced method developed to control mouse X/Y spermatogenesis and sex rati
      Title: RNAi as a tool to control the sex ratio of mouse offspring by interrupting Zfx/Zfy genes in the testis.
    5. Zfx is a common cell-intrinsic regulator of diverse Hedgehog-induced tumors.
      Title: Zfx facilitates tumorigenesis caused by activation of the Hedgehog pathway.
    6. Zfx, a transcription factor that controls hematopoietic stem cell self-renewal, controls the initiation and maintenance of acute myeloid leukemia.
      Title: ZFX controls propagation and prevents differentiation of acute T-lymphoblastic and myeloid leukemia.
    7. Zfx restrains the stress response and couples antigen receptor signaling to cell expansion and maintenance during B-cell development and peripheral homeostasis
      Title: Transcription factor Zfx controls BCR-induced proliferation and survival of B lymphocytes.
    8. These studies identify Zfx as a shared transcriptional regulator of embryonic stem cells and hematopoietic stem cells, suggesting a common genetic basis of self-renewal in embryonic and adult SC.
      Title: Zfx controls the self-renewal of embryonic and hematopoietic stem cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin insulator sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryo development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within fertilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within germ cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within homeostasis of number of cells IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within oocyte development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ovarian follicle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within parental behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger X-chromosomal protein
    Names
    X-linked zinc finger protein
    zinc finger protein X-linked 5
    zinc finger protein X-linked 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044386.1 → NP_001037851.1  zinc finger X-chromosomal protein isoform 1

      See identical proteins and their annotated locations for NP_001037851.1

      Status: VALIDATED

      Source sequence(s)
      AL626786, BF022794
      Consensus CDS
      CCDS30276.1
      UniProtKB/Swiss-Prot
      P17011, P17012, P23607
      UniProtKB/TrEMBL
      B1ASD1
      Related
      ENSMUSP00000085423.6, ENSMUST00000088102.12
      Conserved Domains (6) summary
      COG5048
      Location:537 → 674
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:484 → 504
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:713 → 735
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:71 → 404
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:727 → 751
      zf-H2C2_2; Zinc-finger double domain
      cl19880
      Location:371 → 451
      ROS_MUCR; ROS/MUCR transcriptional regulator protein

    2. NM_001358354.2 → NP_001345283.1  zinc finger X-chromosomal protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL626786
      UniProtKB/Swiss-Prot
      P23607
      UniProtKB/TrEMBL
      B7ZN32
      Conserved Domains (5) summary
      COG5048
      Location:487 → 624
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:434 → 454
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:663 → 685
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:71 → 354
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:677 → 701
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001358355.2 → NP_001345284.1  zinc finger X-chromosomal protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL626786
      UniProtKB/Swiss-Prot
      P23607
      UniProtKB/TrEMBL
      B7ZN32
      Conserved Domains (5) summary
      COG5048
      Location:487 → 624
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:434 → 454
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:663 → 685
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:71 → 354
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:677 → 701
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001358356.2 → NP_001345285.1  zinc finger X-chromosomal protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL626786
      Consensus CDS
      CCDS30276.1
      UniProtKB/Swiss-Prot
      P17011, P17012, P23607
      UniProtKB/TrEMBL
      B1ASD1
      Conserved Domains (6) summary
      COG5048
      Location:537 → 674
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:484 → 504
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:713 → 735
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:71 → 404
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:727 → 751
      zf-H2C2_2; Zinc-finger double domain
      cl19880
      Location:371 → 451
      ROS_MUCR; ROS/MUCR transcriptional regulator protein

    5. NM_001358357.1 → NP_001345286.1  zinc finger X-chromosomal protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL626786, BC028506
      Consensus CDS
      CCDS90734.1
      UniProtKB/TrEMBL
      B1ASD2, Q8R2L1
      Related
      ENSMUSP00000109558.2, ENSMUST00000113925.8
      Conserved Domains (1) summary
      pfam04704
      Location:71 → 210
      Zfx_Zfy_act; Zfx / Zfy transcription activation region

    6. NM_001426089.1 → NP_001413018.1  zinc finger X-chromosomal protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL626786
      UniProtKB/Swiss-Prot
      P17011, P17012
      UniProtKB/TrEMBL
      B1ASD1

    7. NM_001426091.1 → NP_001413020.1  zinc finger X-chromosomal protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL626786
      UniProtKB/TrEMBL
      B7ZN32

    8. NM_001426092.1 → NP_001413021.1  zinc finger X-chromosomal protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL626786
      UniProtKB/Swiss-Prot
      P17011, P17012
      UniProtKB/TrEMBL
      B1ASD1

    9. NM_001426093.1 → NP_001413022.1  zinc finger X-chromosomal protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL626786
      UniProtKB/Swiss-Prot
      P17011, P17012
      UniProtKB/TrEMBL
      B1ASD1

    10. NM_001426094.1 → NP_001413023.1  zinc finger X-chromosomal protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL626786
      UniProtKB/Swiss-Prot
      P17011, P17012
      UniProtKB/TrEMBL
      B1ASD1

    11. NM_001426095.1 → NP_001413024.1  zinc finger X-chromosomal protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL626786
      UniProtKB/Swiss-Prot
      P17011, P17012
      UniProtKB/TrEMBL
      B1ASD1
      Related
      ENSMUSP00000109559.2, ENSMUST00000113926.8

    12. NM_001426096.1 → NP_001413025.1  zinc finger X-chromosomal protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL626786
      UniProtKB/Swiss-Prot
      P17011, P17012
      UniProtKB/TrEMBL
      B1ASD1

    13. NM_001426097.1 → NP_001413026.1  zinc finger X-chromosomal protein isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL626786

    14. NM_001426098.1 → NP_001413027.1  zinc finger X-chromosomal protein isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL626786

    15. NM_001426099.1 → NP_001413028.1  zinc finger X-chromosomal protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL626786
      UniProtKB/TrEMBL
      B7ZN32

    16. NM_001426100.1 → NP_001413029.1  zinc finger X-chromosomal protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL626786
      UniProtKB/TrEMBL
      B7ZN32

    17. NM_001426101.1 → NP_001413030.1  zinc finger X-chromosomal protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL626786
      UniProtKB/TrEMBL
      B7ZN32

    18. NM_001426102.1 → NP_001413031.1  zinc finger X-chromosomal protein isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL626786

    19. NM_001426103.1 → NP_001413032.1  zinc finger X-chromosomal protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL626786
      UniProtKB/Swiss-Prot
      P17011, P17012
      UniProtKB/TrEMBL
      B1ASD1

    20. NM_001426104.1 → NP_001413033.1  zinc finger X-chromosomal protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL626786
      UniProtKB/TrEMBL
      Q8R2L1

    21. NM_001426105.1 → NP_001413034.1  zinc finger X-chromosomal protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL626786
      UniProtKB/TrEMBL
      Q8R2L1

    22. NM_001426106.1 → NP_001413035.1  zinc finger X-chromosomal protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL626786
      UniProtKB/TrEMBL
      Q8R2L1

    23. NM_001426107.1 → NP_001413036.1  zinc finger X-chromosomal protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL626786
      UniProtKB/TrEMBL
      Q8R2L1

    24. NM_001426108.1 → NP_001413037.1  zinc finger X-chromosomal protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL626786
      UniProtKB/TrEMBL
      Q8R2L1

    25. NM_001426109.1 → NP_001413038.1  zinc finger X-chromosomal protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL626786
      UniProtKB/TrEMBL
      Q8R2L1

    26. NM_011768.2 → NP_035898.2  zinc finger X-chromosomal protein isoform 1

      See identical proteins and their annotated locations for NP_035898.2

      Status: VALIDATED

      Source sequence(s)
      AL626786, BF022794
      Consensus CDS
      CCDS30276.1
      UniProtKB/Swiss-Prot
      P17011, P17012, P23607
      UniProtKB/TrEMBL
      B1ASD1
      Related
      ENSMUSP00000109560.2, ENSMUST00000113927.8
      Conserved Domains (6) summary
      COG5048
      Location:537 → 674
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:484 → 504
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:713 → 735
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:71 → 404
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:727 → 751
      zf-H2C2_2; Zinc-finger double domain
      cl19880
      Location:371 → 451
      ROS_MUCR; ROS/MUCR transcriptional regulator protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      93118237..93194250 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527967.4 → XP_006528030.1  zinc finger X-chromosomal protein isoform X3

      UniProtKB/Swiss-Prot
      P23607
      Conserved Domains (5) summary
      COG5048
      Location:520 → 644
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:467 → 487
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:696 → 718
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:104 → 387
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:539 → 563
      zf-H2C2_2; Zinc-finger double domain

    2. XM_006527965.4 → XP_006528028.1  zinc finger X-chromosomal protein isoform X1

      UniProtKB/Swiss-Prot
      P23607
      Conserved Domains (4) summary
      COG5048
      Location:570 → 832
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:517 → 537
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:452 → 474
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:104 → 437
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17012.2 GenPept UniProtKB/Swiss-Prot:P17012

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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