Timm44 translocase of inner mitochondrial membrane 44 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Timm44provided by MGI
Official Full Name: translocase of inner mitochondrial membrane 44provided by MGI
Primary source: MGI:MGI:1343262
See related: Ensembl:ENSMUSG00000002949 AllianceGenome:MGI:1343262
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tim44; Mimt44; D8Ertd118e; 0710005E20Rik
Summary: Predicted to enable enzyme binding activity and protein-folding chaperone binding activity. Predicted to be involved in intracellular protein transport and protein import into mitochondrial matrix. Located in mitochondrial inner membrane. Is expressed in cerebral cortex ventricular layer; cortical plate; and liver. Orthologous to human TIMM44 (translocase of inner mitochondrial membrane 44). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in heart adult (RPKM 25.6), CNS E11.5 (RPKM 21.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 A1.1; 8 1.99 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (4309731..4325905, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (4259731..4275905, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The mitochondrial protein TIMM44 is required for angiogenesis in vitro and in vivo.
Title: The mitochondrial protein TIMM44 is required for angiogenesis in vitro and in vivo.
TIMM44 is a potential therapeutic target of human glioma.
Title: TIMM44 is a potential therapeutic target of human glioma.
TIM44 was identified for the first time as a potential oncogene, which plays an important role in autophagy through the TIM44-SOD2-ROS-mTOR pathway.
Title: Identification of a fluorescent small-molecule enhancer for therapeutic autophagy in colorectal cancer by targeting mitochondrial protein translocase TIM44.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:493321

RH126119 (e-PCR)
- UniSTS:162831

RH140740 (e-PCR)
- UniSTS:222806

AW742190 (e-PCR)
- UniSTS:208234

C77206 (e-PCR)
- UniSTS:159731

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-folding chaperone binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein-folding chaperone binding	IEA Inferred from Electronic Annotation more info
enables protein-folding chaperone binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in intracellular protein transport	ISO Inferred from Sequence Orthology more info
involved_in protein import into mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into mitochondrial matrix	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of TIM23 mitochondrial import inner membrane translocase complex	IEA Inferred from Electronic Annotation more info
part_of TIM23 mitochondrial import inner membrane translocase complex	ISO Inferred from Sequence Orthology more info
located_in fibrillar center	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	HDA more info	PubMed
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitochondrial import inner membrane translocase subunit TIM44

Names: translocator of inner mitochondrial membrane 44; translocator of inner mitochondrial membrane 44; DNA segment, Chr 8, ERATO Doi 118, expressed

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011592.2 → NP_035722.2 mitochondrial import inner membrane translocase subunit TIM44

See identical proteins and their annotated locations for NP_035722.2

Status: VALIDATED

Source sequence(s)

BC117523, BQ031430, CA493459

Consensus CDS

CCDS22083.1

UniProtKB/Swiss-Prot

O35857, Q2NLC5

UniProtKB/TrEMBL

Q8R3X4

Related

ENSMUSP00000003029.8, ENSMUST00000003029.14

Conserved Domains (3) summary

TIGR00984
Location:65 → 442

3a0801s03tim44; mitochondrial import inner membrane, translocase subunit

pfam04280
Location:297 → 445

Tim44; Tim44-like domain

cl21509
Location:74 → 187

ApoLp-III_like; Apolipophorin-III and similar insect proteins