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    Mog myelin oligodendrocyte glycoprotein [ Mus musculus (house mouse) ]

    Gene ID: 17441, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mogprovided by MGI
    Official Full Name
    myelin oligodendrocyte glycoproteinprovided by MGI
    Primary source
    MGI:MGI:97435
    See related
    Ensembl:ENSMUSG00000076439 AllianceGenome:MGI:97435
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B230317G11Rik
    Summary
    Predicted to enable signaling receptor binding activity. Predicted to be involved in T cell receptor signaling pathway and regulation of cytokine production. Located in myelin sheath. Is expressed in brain; cerebellum; and dentate gyrus subgranular zone. Human ortholog(s) of this gene implicated in multiple sclerosis; narcolepsy; and optic neuritis. Orthologous to human MOG (myelin oligodendrocyte glycoprotein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 31.3), cortex adult (RPKM 21.2) and 4 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mog in Genome Data Viewer
    Location:
    17 B1; 17 19.16 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (37321632..37334290, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (37010740..37023398, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2410137M14 gene Neighboring gene histocompatibility 2, M region locus 4, pseudogene Neighboring gene histocompatibility 2, M region locus 5 Neighboring gene STARR-seq mESC enhancer starr_42498 Neighboring gene STARR-seq mESC enhancer starr_42499 Neighboring gene zinc finger protein 57 Neighboring gene STARR-seq mESC enhancer starr_42503 Neighboring gene STARR-seq mESC enhancer starr_42504 Neighboring gene gamma-aminobutyric acid type B receptor subunit 1 Neighboring gene STARR-seq mESC enhancer starr_42506 Neighboring gene olfactory receptor family 2 subfamily H member 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (6)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in T cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in myelin sheath HDA PubMed 

    General protein information

    Preferred Names
    myelin-oligodendrocyte glycoprotein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010814.2NP_034944.2  myelin-oligodendrocyte glycoprotein precursor

      See identical proteins and their annotated locations for NP_034944.2

      Status: VALIDATED

      Source sequence(s)
      BC080860, BY127313, CD776673, CR956641
      Consensus CDS
      CCDS28734.1
      UniProtKB/Swiss-Prot
      P70364, Q61885, Q62003
      UniProtKB/TrEMBL
      Q3UY21
      Related
      ENSMUSP00000099726.5, ENSMUST00000102665.11
      Conserved Domains (2) summary
      cd05713
      Location:46144
      Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
      smart00410
      Location:40144
      IG_like; Immunoglobulin like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      37321632..37334290 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)