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    Prl8a2 prolactin family 8, subfamily a, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 13529, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Prl8a2provided by MGI
    Official Full Name
    prolactin family 8, subfamily a, member 2provided by MGI
    Primary source
    MGI:MGI:894281
    See related
    Ensembl:ENSMUSG00000018259 AllianceGenome:MGI:894281
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DPRP; Dtprp; Ghd11; mdPRP; D/tPRP
    Summary
    Predicted to enable hormone activity and prolactin receptor binding activity. Acts upstream of or within maternal process involved in female pregnancy and response to hypoxia. Predicted to be active in extracellular space. Is expressed in branchial arch; extraembryonic component; and placenta. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward placenta adult (RPKM 101.9) See more
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    Genomic context

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    See Prl8a2 in Genome Data Viewer
    Location:
    13 A3.1; 13 12.41 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (27529656..27538199)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (27345673..27354216)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene prolactin family 3, subfamily a, member 1 Neighboring gene craniofacial development protein 1 pseudogene Neighboring gene prolactin family 6, subfamily a, member 1 Neighboring gene STARR-seq mESC enhancer starr_34015 Neighboring gene prolactin family 2, subfamily b, member 1 Neighboring gene predicted gene, 40836 Neighboring gene prolactin family 8, subfamily a, member 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Histamine promotes mouse decidualization through stimulating epithelial amphiregulin release. Liu CK, et al. FEBS J, 2024 Sep. PMID 38973142
    2. Identification of target genes for a prolactin family paralog in mouse decidua. Alam SM, et al. Reproduction, 2015 Jun. PMID 25926690, Free PMC Article
    3. A uterine decidual cell cytokine ensures pregnancy-dependent adaptations to a physiological stressor. Alam SM, et al. Development, 2007 Jan. PMID 17166917
    4. Modulation of steroidogenic enzymes in murine lymphoid organs after immune activation. Mukhopadhyay R, et al. Immunol Invest, 2009. PMID 19172483
    5. Uterine Prx2 restrains decidual differentiation through inhibiting lipolysis in mice. Jiang Y, et al. Cell Tissue Res, 2016 Aug. PMID 26987819

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Uterine Notch2 facilitates pregnancy recognition and corpus luteum maintenance via upregulating decidual Prl8a2.
      Title: Uterine Notch2 facilitates pregnancy recognition and corpus luteum maintenance via upregulating decidual Prl8a2.
    2. The first SNP rs29972765 is located in a gene desert on chromosome 18, about 72 kb upstream of Skor2 . The second SNP rs30415957 resides in the intron of Plce1.The remaining two SNPs (rs30768258 and rs31216810) are close to each other on chromosome 19, in the vicinity of Sorbs1. Knockdown of Sorbs1 by siRNA attenuates the induction of differentiation marker gene Prl8a2
      Title: Genome-Wide Association Mapping for Female Infertility in Inbred Mice.
    3. present in the lymphoid organs after immunization with soluble antigen
      Title: Modulation of steroidogenic enzymes in murine lymphoid organs after immune activation.
    4. 17 beta-estradiol and progesterone induced expression of mRNA for the decidual/trophoblastic PRL-related protein (d/tPRP) in cultured mouse endometrial stromal cells
      Title: Messenger ribonucleic acid for the mouse decidual prolactin is present and induced during in vitro decidualization of endometrial stromal cells.
    5. DPRP deficiency interfered with pregnancy-dependent adaptations to hypoxia resulting in pregnancy failure.
      Title: A uterine decidual cell cytokine ensures pregnancy-dependent adaptations to a physiological stressor.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables prolactin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in female pregnancy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mammary gland development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within maternal process involved in female pregnancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of lactation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to nutrient levels IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    prolactin family 8, subfamily a, member 2
    Names
    decidual/trophoblast prolactin-related protein
    growth hormone d11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289919.1 → NP_001276848.1  prolactin family 8, subfamily a, member 2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001276848.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AK131668, D19302
      Consensus CDS
      CCDS70440.1
      UniProtKB/TrEMBL
      O35258
      Related
      ENSMUSP00000105992.2, ENSMUST00000110363.9
      Conserved Domains (1) summary
      cd10288
      Location:29 → 239
      prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

    2. NM_010088.2 → NP_034218.1  prolactin family 8, subfamily a, member 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_034218.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF011385, AK131668, D19302
      Consensus CDS
      CCDS26396.1
      UniProtKB/TrEMBL
      O54832
      Related
      ENSMUSP00000018403.7, ENSMUST00000018403.8
      Conserved Domains (1) summary
      cd10288
      Location:30 → 240
      prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      27529656..27538199
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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