Eif3i eukaryotic translation initiation factor 3, subunit I [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Eif3iprovided by MGI
Official Full Name: eukaryotic translation initiation factor 3, subunit Iprovided by MGI
Primary source: MGI:MGI:1860763
See related: Ensembl:ENSMUSG00000028798 AllianceGenome:MGI:1860763
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 36kDa; Trip1; Eif3s2; D4Ertd632e
Summary: Contributes to translation initiation factor activity. Involved in translational initiation. Part of eukaryotic translation initiation factor 3 complex, eIF3m. Is active in synapse. Is expressed in several structures, including extracellular matrix; jaw; oral epithelium; and skeleton. Orthologous to human EIF3I (eukaryotic translation initiation factor 3 subunit I). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in genital fat pad adult (RPKM 152.6), liver E14.5 (RPKM 125.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.2; 4 63.26 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (129485767..129494441, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (129591974..129600648, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

circEIF3I facilitates the recruitment of SMAD3 to early endosomes to promote TGF-beta signalling pathway-mediated activation of MMPs in pancreatic cancer.
Title: circEIF3I facilitates the recruitment of SMAD3 to early endosomes to promote TGF-β signalling pathway-mediated activation of MMPs in pancreatic cancer.
eIF3b regulates the cell proliferation and apoptosis processes in chronic myelogenous leukemia cell lines via regulating the expression of C3G.
Title: eIF3b regulates the cell proliferation and apoptosis processes in chronic myelogenous leukemia cell lines via regulating the expression of C3G.
TRIP-1 overexpression protects alveolar epithelial cells against hyperoxic acute lung injury.
Title: Lung epithelial-specific TRIP-1 overexpression maintains epithelial integrity during hyperoxia exposure.
TRIP-1 is a secreted protein and is present in the secretome of primary osteoblasts and in the extracellular matrix.TRIP-1 binds to type I collagen.TRIP-1 promotes calcium phosphate deposition.
Title: TGF beta receptor II interacting protein-1, an intracellular protein has an extracellular role as a modulator of matrix mineralization.
TRIP-1 is a regulator of osteoblast function
Title: TRIP-1: a regulator of osteoblast function.
Mc1r(e) mutation affects the proliferation and differentiation of melanocytes and l-Tyr rescues the reduced proliferative and differentiative activities by stimulating TYR activity and TRP1 and TRP2 expressions as well as melanosome maturation
Title: Excess tyrosine rescues the reduced activity of proliferation and differentiation of cultured recessive yellow melanocytes derived from neonatal mouse epidermis.
the up-regulation of expression of TIF3 is a novel molecular mechanism responsible, at least in part, for cadmium carcinogenesis
Title: Up-regulation of expression of translation factors--a novel molecular mechanism for cadmium carcinogenesis.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH140878 (e-PCR)
- UniSTS:222894

D4Ertd632e (e-PCR), detects polymorphism
- UniSTS:167406

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to translation initiation factor activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to translation initiation factor activity	ISO Inferred from Sequence Orthology more info
enables translation initiation factor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cytoplasmic translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in formation of cytoplasmic translation initiation complex	IEA Inferred from Electronic Annotation more info
involved_in translational initiation	IDA Inferred from Direct Assay more info	PubMed
involved_in translational initiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of eukaryotic 43S preinitiation complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic 48S preinitiation complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 3 complex	IDA Inferred from Direct Assay more info	PubMed
part_of eukaryotic translation initiation factor 3 complex	ISO Inferred from Sequence Orthology more info
part_of eukaryotic translation initiation factor 3 complex, eIF3m	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 3 complex, eIF3m	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: eukaryotic translation initiation factor 3 subunit I

Names: TGF-beta receptor binding protein; TGF-beta receptor-interacting protein 1; TRIP-1; eukaryotic translation initiation factor 3, subunit 1; eukaryotic translation initiation factor 3, subunit 2 (beta); eukaryotic translation initiation factor 3, subunit 2 (beta, 36kD)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_018799.2 → NP_061269.1 eukaryotic translation initiation factor 3 subunit I

See identical proteins and their annotated locations for NP_061269.1

Status: VALIDATED

Source sequence(s)

AK010781, BP769420, CJ079467

Consensus CDS

CCDS18698.1

UniProtKB/Swiss-Prot

Q9QZD9

UniProtKB/TrEMBL

Q3T9Y8

Related

ENSMUSP00000099653.5, ENSMUST00000102593.11

Conserved Domains (3) summary

COG2319
Location:6 → 311

WD40; WD40 repeat [General function prediction only]

sd00039
Location:14 → 50

7WD40; WD40 repeat [structural motif]

cl02567
Location:6 → 311

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...