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    Fank1 fibronectin type 3 and ankyrin repeat domains 1 [ Mus musculus (house mouse) ]

    Gene ID: 66930, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Fank1provided by MGI
    Official Full Name
    fibronectin type 3 and ankyrin repeat domains 1provided by MGI
    Primary source
    MGI:MGI:1914180
    See related
    Ensembl:ENSMUSG00000053111 AllianceGenome:MGI:1914180
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FANK1S; 1700007B22Rik
    Summary
    Predicted to be involved in regulation of DNA-templated transcription and regulation of apoptotic process. Located in ciliary basal body. Is active in ciliary base. Is expressed in lung. Orthologous to human FANK1 (fibronectin type III and ankyrin repeat domains 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 86.5) and CNS E18 (RPKM 2.7) See more
    Orthologs
    human all
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    Genomic context

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    See Fank1 in Genome Data Viewer
    Location:
    7 F3; 7 77.42 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (133378594..133483261)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (133776836..133881536)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10481 Neighboring gene uroporphyrinogen III synthase Neighboring gene STARR-seq mESC enhancer starr_20333 Neighboring gene BRCA2 and CDKN1A interacting protein Neighboring gene DEAH-box helicase 32 (putative) Neighboring gene predicted gene 15483 Neighboring gene STARR-seq mESC enhancer starr_20336 Neighboring gene ADAM metallopeptidase domain 12 Neighboring gene STARR-seq mESC enhancer starr_20337 Neighboring gene predicted gene, 51500 Neighboring gene STARR-seq mESC enhancer starr_20338 Neighboring gene predicted gene, 39103

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Normal spermatogenesis in Fank1 (fibronectin type 3 and ankyrin repeat domains 1) mutant mice. Zhang J, et al. PeerJ, 2019. PMID 31086747, Free PMC Article
    2. Fank1 is a testis-specific gene encoding a nuclear protein exclusively expressed during the transition from the meiotic to the haploid phase of spermatogenesis. Zheng Z, et al. Gene Expr Patterns, 2007 Aug. PMID 17604233
    3. Specific maternal transcripts in bovine oocytes and cleavaged embryos: identification with novel DDRT-PCR methods. Hwang KC, et al. Mol Reprod Dev, 2005 Jul. PMID 15803458
    4. Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Stauber M, et al. Dev Biol, 2017 Mar 15. PMID 27914912
    5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FANK1 may have a role in regulating gene expression in the transition from the meiotic phase to the haploid phase during spermatogenesis
      Title: Fank1 is a testis-specific gene encoding a nuclear protein exclusively expressed during the transition from the meiotic to the haploid phase of spermatogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT acts_upstream_of_or_within regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in ciliary base IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    fibronectin type 3 and ankyrin repeat domains 1 protein
    Names
    GSG1
    germ cell-specific 1
    germ cell-specific gene 1 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418758.1 → NP_001405687.1  fibronectin type 3 and ankyrin repeat domains 1 protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC127348, AC149611

    2. NM_025850.3 → NP_080126.1  fibronectin type 3 and ankyrin repeat domains 1 protein isoform 1

      See identical proteins and their annotated locations for NP_080126.1

      Status: VALIDATED

      Source sequence(s)
      AC127348, AC149611
      Consensus CDS
      CCDS21937.1
      UniProtKB/Swiss-Prot
      Q9CUA7, Q9DAM9
      UniProtKB/TrEMBL
      A0A1B0GSJ7
      Related
      ENSMUSP00000069013.6, ENSMUST00000065359.12
      Conserved Domains (6) summary
      cd00063
      Location:10 → 104
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00204
      Location:171 → 298
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00023
      Location:144 → 174
      Ank; Ankyrin repeat
      pfam12796
      Location:148 → 240
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:113 → 164
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:176 → 207
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      133378594..133483261
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DAM9.1 GenPept UniProtKB/Swiss-Prot:Q9DAM9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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