Tesmin testis expressed metallothionein like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tesminprovided by MGI
Official Full Name: testis expressed metallothionein likeprovided by MGI
Primary source: MGI:MGI:1340029
See related: Ensembl:ENSMUSG00000024905 AllianceGenome:MGI:1340029
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mtl5
Summary: Involved in male meiotic nuclear division and spermatogenesis. Located in cytoplasm and male germ cell nucleus. Is expressed in several structures, including adrenal gland; gonad; heart; liver; and lung. Orthologous to human TESMIN (testis expressed metallothionein like protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward testis adult (RPKM 35.1) See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 3.15 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (3438857..3457823)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (3388857..3407823)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Metallothionein-like 5 expression is correlated with poor prognosis and promotes proliferation of cervical squamous cell carcinoma.
Title: Metallothionein-like 5 expression is correlated with poor prognosis and promotes proliferation of cervical squamous cell carcinoma.
Nuclear translocation of MTL5 from cytoplasm requires its direct interaction with LIN9 and is essential for male meiosis and fertility.
Title: Nuclear translocation of MTL5 from cytoplasm requires its direct interaction with LIN9 and is essential for male meiosis and fertility.
Tesmin, Metallothionein-Like 5, is Required for Spermatogenesis in Micedagger.
Title: Tesmin, Metallothionein-Like 5, is Required for Spermatogenesis in Mice†.
regulation of the tesmin nucleocytoplasmic shuttling by the effect of metal stress
Title: Germ cell-specific nucleocytoplasmic shuttling protein, tesmin, responsive to heavy metal stress in mouse testes.
Data suggest that tesmin transcription may be controlled by two different mechanisms during male and female meiosis.
Title: Tesmin transcription is regulated differently during male and female meiosis.
tesmin is involved in multiple stages of spermatogenesis and spermiogenesis
Title: Native tesmin is a 60-kilodalton protein that undergoes dynamic changes in its localization during spermatogenesis in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation

General gene information

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Markers

AU048745 (e-PCR)
- UniSTS:145195

AU048852 (e-PCR)
- UniSTS:145302

Mtl5 (e-PCR), detects polymorphism
- UniSTS:275893

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in male meiotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in male germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: tesmin

Names: metallothionein-like 5, testis-specific (tesmin); testis-specific metallothionein-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039657.2 → NP_001034746.1 tesmin isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a).

Source sequence(s)

AK015724, AK015732, AK161511

Consensus CDS

CCDS37880.1

UniProtKB/Swiss-Prot

Q548K4, Q8VIE0, Q8VIE1, Q9WTJ6

Related

ENSMUSP00000025840.10, ENSMUST00000025840.16

Conserved Domains (1) summary

pfam03638
Location:334 → 371

TCR; Tesmin/TSO1-like CXC domain, cysteine-rich domain
NM_001039658.2 → NP_001034747.1 tesmin isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks several exons, and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a shorter and distinct C-terminus, compared to isoform a.

Source sequence(s)

AK015732, AK161511

Consensus CDS

CCDS50339.1

UniProtKB/TrEMBL

Q9D571

Related

ENSMUSP00000114142.2, ENSMUST00000151341.8
NM_001286557.1 → NP_001273486.1 tesmin isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a. Both variants 3 and 4 encode the same isoform.

Source sequence(s)

AK015724, AK161511, AL626765

Consensus CDS

CCDS70912.1

UniProtKB/Swiss-Prot

Q9WTJ6

Related

ENSMUSP00000114171.2, ENSMUST00000142193.8

Conserved Domains (1) summary

pfam03638
Location:154 → 191

TCR; Tesmin/TSO1-like CXC domain, cysteine-rich domain
NM_001286558.1 → NP_001273487.1 tesmin isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a. Both variants 3 and 4 encode the same isoform.

Source sequence(s)

AK015724, AK161511, AL626765

Consensus CDS

CCDS70912.1

UniProtKB/Swiss-Prot

Q9WTJ6

Related

ENSMUSP00000122687.2, ENSMUST00000127142.2

Conserved Domains (1) summary

pfam03638
Location:154 → 191

TCR; Tesmin/TSO1-like CXC domain, cysteine-rich domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

3438857..3457823

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_010841.1: Suppressed sequence

Description

NM_010841.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.