Zmiz1 zinc finger, MIZ-type containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zmiz1provided by MGI
Official Full Name: zinc finger, MIZ-type containing 1provided by MGI
Primary source: MGI:MGI:3040693
See related: Ensembl:ENSMUSG00000007817 AllianceGenome:MGI:3040693
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rai17; Zimp10; Gm10397; E330020C23; I920194n01
Summary: Predicted to enable SMAD binding activity; SUMO ligase activity; and nuclear receptor coactivator activity. Involved in positive regulation of Notch signaling pathway and positive regulation of T cell differentiation. Acts upstream of or within several processes, including circulatory system development; positive regulation of fibroblast proliferation; and vitellogenesis. Predicted to be located in chromatin; cytosol; and nucleoplasm. Is expressed in several structures, including early embryo; embryo ectoderm; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human ZMIZ1 (zinc finger MIZ-type containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 35.4), limb E14.5 (RPKM 30.1) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 A3; 14 15.03 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (25458299..25667167)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (25457875..25666743)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zmiz1 is a novel regulator of lymphatic endothelial cell gene expression and function.
Title: Zmiz1 is a novel regulator of lymphatic endothelial cell gene expression and function.
Zmiz1 is required for mature beta-cell function and mass expansion upon high fat feeding.
Title: Zmiz1 is required for mature β-cell function and mass expansion upon high fat feeding.
Zmiz1 is a context-specific cofactor for Notch1 during Notch/Myc-dependent thymocyte proliferation, whether normal or malignant.
Title: Stage-specific roles for Zmiz1 in Notch-dependent steps of early T-cell development.
Ectopic expression of Zmiz1 induces cutaneous squamous cell malignancies in a mouse model of cancer.
Title: Ectopic expression of Zmiz1 induces cutaneous squamous cell malignancies in a mouse model of cancer.
we show that activated NOTCH1 and ZMIZ1 collaborate to induce T-ALL in mice.
Title: Convergence of the ZMIZ1 and NOTCH1 pathways at C-MYC in acute T lymphoblastic leukemias.
Zimp10 is found in somatic cells, outside the testis cords and ceases to be expressed in the adult testis.
Title: Sexually dimorphic gene expression of the Zimp7 and Zimp10 genes in embryonic gonads.
provides evidence to demonstrate a crucial role for Zimp10 in vasculogenesis
Title: The PIAS-like protein Zimp10 is essential for embryonic viability and proper vascular development.
A physiological role for Zimp10 in regulating Smad3/4-mediated transcription is demonstrated in mouse embryonic fibroblasts.
Title: The novel PIAS-like protein hZimp10 enhances Smad transcriptional activity.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D14Mit209 (e-PCR), detects polymorphism
- UniSTS:127322

Zmiz1 (e-PCR), detects polymorphism
- UniSTS:528072

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SMAD binding	IEA Inferred from Electronic Annotation more info
enables SMAD binding	ISO Inferred from Sequence Orthology more info
enables SUMO ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IEA Inferred from Electronic Annotation more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in SMAD protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in androgen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in androgen receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within artery morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular senescence	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within developmental growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of fibroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein sumoylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in pyramidal neuron migration to cerebral cortex	IEA Inferred from Electronic Annotation more info
involved_in pyramidal neuron migration to cerebral cortex	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in transforming growth factor beta receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within vasculogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vitellogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc finger MIZ domain-containing protein 1

Names: PIAS-like protein Zimp10; retinoic acid induced 17; retinoic acid-induced protein 17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001310666.1 → NP_001297595.1 zinc finger MIZ domain-containing protein 1 isoform 2

See identical proteins and their annotated locations for NP_001297595.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) has the same N- and C-termini, but is shorter than isoform 1.

Source sequence(s)

AK132106, AK138053, BC058646, BQ748452, BU059092

Consensus CDS

CCDS79280.1

UniProtKB/Swiss-Prot

Q6P1E1

UniProtKB/TrEMBL

Q3V215

Related

ENSMUSP00000007961.9, ENSMUST00000007961.15

Conserved Domains (2) summary

cd16791
Location:740 → 787

SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins

cl26464
Location:192 → 556

Atrophin-1; Atrophin-1 family
NM_183208.4 → NP_899031.2 zinc finger MIZ domain-containing protein 1 isoform 1

See identical proteins and their annotated locations for NP_899031.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK132106, AK138053, BC065120, BQ748452, CF732350

Consensus CDS

CCDS26873.1

UniProtKB/Swiss-Prot

Q6P1E1, Q6PDK9, Q6PF85, Q8BW47

Related

ENSMUSP00000124863.2, ENSMUST00000162645.8

Conserved Domains (3) summary

PHA03247
Location:119 → 546

PHA03247; large tegument protein UL36; Provisional

cd16791
Location:746 → 793

SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins

pfam18028
Location:8 → 100

Zmiz1_N; Zmiz1 N-terminal tetratricopeptide repeat domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

25458299..25667167

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006519134.4 → XP_006519197.1 zinc finger MIZ domain-containing protein 1 isoform X2

Conserved Domains (3) summary

PHA03247
Location:119 → 546

PHA03247; large tegument protein UL36; Provisional

cd16791
Location:746 → 793

SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins

pfam18028
Location:8 → 100

Zmiz1_N; Zmiz1 N-terminal tetratricopeptide repeat domain
XM_036158678.1 → XP_036014571.1 zinc finger MIZ domain-containing protein 1 isoform X3

Conserved Domains (3) summary

PHA03247
Location:118 → 556

PHA03247; large tegument protein UL36; Provisional

cd16791
Location:740 → 787

SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins

pfam18028
Location:8 → 100

Zmiz1_N; Zmiz1 N-terminal tetratricopeptide repeat domain
XM_036158677.1 → XP_036014570.1 zinc finger MIZ domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

Q6P1E1, Q6PDK9, Q6PF85, Q8BW47

Conserved Domains (3) summary

PHA03247
Location:119 → 546

PHA03247; large tegument protein UL36; Provisional

cd16791
Location:746 → 793

SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins

pfam18028
Location:8 → 100

Zmiz1_N; Zmiz1 N-terminal tetratricopeptide repeat domain
XM_030247864.2 → XP_030103724.1 zinc finger MIZ domain-containing protein 1 isoform X4

Conserved Domains (2) summary

PHA03247
Location:61 → 439

PHA03247; large tegument protein UL36; Provisional

cd16791
Location:622 → 669

SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
XM_030247865.2 → XP_030103725.1 zinc finger MIZ domain-containing protein 1 isoform X5

Conserved Domains (2) summary

PHA03247
Location:68 → 432

PHA03247; large tegument protein UL36; Provisional

cd16791
Location:616 → 663

SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
XM_036158679.1 → XP_036014572.1 zinc finger MIZ domain-containing protein 1 isoform X6

Conserved Domains (2) summary

PHA03247
Location:68 → 432

PHA03247; large tegument protein UL36; Provisional

cd16791
Location:616 → 663

SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
XM_030247863.2 → XP_030103723.1 zinc finger MIZ domain-containing protein 1 isoform X4

Conserved Domains (2) summary

PHA03247
Location:61 → 439

PHA03247; large tegument protein UL36; Provisional

cd16791
Location:622 → 669

SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001033402.2: Suppressed sequence

Description

NM_001033402.2: This RefSeq was temporarily suppressed because currently there is insufficient support for the transcript and the protein.