Mettl23 methyltransferase like 23 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mettl23provided by MGI
Official Full Name: methyltransferase like 23provided by MGI
Primary source: MGI:MGI:1921569
See related: Ensembl:ENSMUSG00000090266 AllianceGenome:MGI:1921569
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1110005A03Rik; 1500035B17Rik; 4933424L15Rik
Summary: Enables histone H3R17 methyltransferase activity. Involved in epigenetic programming in the zygotic pronuclei. Acts upstream of with a positive effect on epigenetic programing of male pronucleus. Located in cytoplasm and female pronucleus. Is active in male pronucleus. Is expressed in embryo. Used to study glaucoma. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 44. Orthologous to human METTL23 (methyltransferase 23, arginine). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 16.8), mammary gland adult (RPKM 12.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 81.49 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (116734341..116740566)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (116843515..116849740)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

METTL23 mutation alters histone H3R17 methylation in normal-tension glaucoma.
Title: METTL23 mutation alters histone H3R17 methylation in normal-tension glaucoma.
Located immediately downstream of Jmjd6, with a bi-directionar promoter between the two.
Title: Genomic structure and expression of Jmjd6 and evolutionary analysis in the context of related JmjC domain containing proteins.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation

General gene information

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Markers

D11Wsu175e (e-PCR), detects polymorphism
- UniSTS:141827

1110005A03Rik (e-PCR), detects polymorphism
- UniSTS:526961

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables heat shock protein binding	IEA Inferred from Electronic Annotation more info
enables heat shock protein binding	ISO Inferred from Sequence Orthology more info
enables histone H3R17 methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3R17 methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone methyltransferase activity	TAS Traceable Author Statement more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-arginine omega-N asymmetric methyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cognition	IEA Inferred from Electronic Annotation more info
involved_in cognition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect epigenetic programing of male pronucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epigenetic programming in the zygotic pronuclei	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epigenetic regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in female pronucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in male pronucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histone-arginine methyltransferase METTL23

Names: methyltransferase-like protein 23; probable methyltransferase-like protein 23

NP_083141.3

EC 2.1.1.319

XP_006534423.1

EC 2.1.1.319

XP_036012939.1

EC 2.1.1.319

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028865.3 → NP_083141.3 histone-arginine methyltransferase METTL23

See identical proteins and their annotated locations for NP_083141.3

Status: VALIDATED

Source sequence(s)

AK003450, AW490033, BY122329

Consensus CDS

CCDS25679.2

UniProtKB/Swiss-Prot

A2AA28, Q8R2Z2, Q9D1J5

Related

ENSMUSP00000101978.4, ENSMUST00000106370.10

Conserved Domains (1) summary

cl17173
Location:63 → 189

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

116734341..116740566

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006534360.4 → XP_006534423.1 histone-arginine methyltransferase METTL23 isoform X1

Conserved Domains (1) summary

cl17173
Location:3 → 126

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_036157046.1 → XP_036012939.1 histone-arginine methyltransferase METTL23 isoform X1

Conserved Domains (1) summary

cl17173
Location:3 → 126

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...