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    Zfp771 zinc finger protein 771 [ Mus musculus (house mouse) ]

    Gene ID: 244216, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfp771provided by MGI
    Official Full Name
    zinc finger protein 771provided by MGI
    Primary source
    MGI:MGI:2442050
    See related
    Ensembl:ENSMUSG00000054716 AllianceGenome:MGI:2442050
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf771; G630024C07Rik
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in nucleus. Orthologous to human ZNF771 (zinc finger protein 771). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 158.9), adrenal adult (RPKM 143.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp771 in Genome Data Viewer
    Location:
    7 F3; 7 69.41 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126842168..126854044)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127242996..127254872)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene myosin light chain, phosphorylatable, fast skeletal muscle Neighboring gene septin 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134361531-134361732 Neighboring gene STARR-seq mESC enhancer starr_20173 Neighboring gene STARR-seq mESC enhancer starr_20176 Neighboring gene predicted gene 4532 Neighboring gene zinc finger protein 553 Neighboring gene STARR-seq mESC enhancer starr_20179 Neighboring gene STARR-positive B cell enhancer ABC_E6605 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134404258-134404441 Neighboring gene dCTP pyrophosphatase 1 Neighboring gene selenophosphate synthetase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TRIB3 promotes pulmonary fibrosis through inhibiting SLUG degradation by physically interacting with MDM2. Lv X, et al. Acta Pharm Sin B, 2023 Apr. PMID 37139431, Free PMC Article
    2. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article
    3. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 771
    Names
    mesenchymal stem cell protein DSC43

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360916.1 → NP_001347845.1  zinc finger protein 771 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AA030159, AC133494
      Conserved Domains (3) summary
      COG5048
      Location:39 → 194
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:14 → 34
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:194 → 218
      zf-H2C2_2; Zinc-finger double domain

    2. NM_177362.4 → NP_796336.1  zinc finger protein 771 isoform 1

      See identical proteins and their annotated locations for NP_796336.1

      Status: VALIDATED

      Source sequence(s)
      AC133494, AK090240
      Consensus CDS
      CCDS21861.1
      UniProtKB/Swiss-Prot
      B2RSX6, Q6P5I0, Q8BJ90
      Related
      ENSMUSP00000056959.4, ENSMUST00000052509.6
      Conserved Domains (3) summary
      COG5048
      Location:90 → 245
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:65 → 85
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:245 → 269
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      126842168..126854044
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507843.3 → XP_006507906.1  zinc finger protein 771 isoform X1

      See identical proteins and their annotated locations for XP_006507906.1

      UniProtKB/Swiss-Prot
      B2RSX6, Q6P5I0, Q8BJ90
      Conserved Domains (3) summary
      COG5048
      Location:90 → 245
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:65 → 85
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:245 → 269
      zf-H2C2_2; Zinc-finger double domain

    2. XM_030242585.1 → XP_030098445.1  zinc finger protein 771 isoform X2

      Conserved Domains (3) summary
      COG5048
      Location:39 → 194
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:14 → 34
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:194 → 218
      zf-H2C2_2; Zinc-finger double domain

    3. XM_030242586.1 → XP_030098446.1  zinc finger protein 771 isoform X2

      Conserved Domains (3) summary
      COG5048
      Location:39 → 194
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:14 → 34
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:194 → 218
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BJ90.1 GenPept UniProtKB/Swiss-Prot:Q8BJ90

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