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    Trabd2b TraB domain containing 2B [ Mus musculus (house mouse) ]

    Gene ID: 666048, updated on 9-Dec-2024

    Summary

    Official Symbol
    Trabd2bprovided by MGI
    Official Full Name
    TraB domain containing 2Bprovided by MGI
    Primary source
    MGI:MGI:3650152
    See related
    Ensembl:ENSMUSG00000070867 AllianceGenome:MGI:3650152
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hkat; Gm12824
    Summary
    Predicted to enable Wnt-protein binding activity and metalloendopeptidase activity. Predicted to be involved in several processes, including negative regulation of Wnt signaling pathway; positive regulation of protein oxidation; and positive regulation of protein-containing complex assembly. Predicted to be active in organelle membrane and plasma membrane. Is expressed in several structures, including brain; extraembryonic component; genitourinary system; neural ectoderm; and respiratory system. Orthologous to human TRABD2B (TraB domain containing 2B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in kidney adult (RPKM 13.3), heart adult (RPKM 12.4) and 13 other tissues See more
    Orthologs
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    Genomic context

    See Trabd2b in Genome Data Viewer
    Location:
    4 D1; 4 51.84 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (114263394..114472295)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (114406682..114615098)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene selection and upkeep of intraepithelial T cells 11 Neighboring gene TRAF3 interacting protein 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_11102 Neighboring gene predicted gene, 40228 Neighboring gene predicted gene, 33710 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:114273999-114274108 Neighboring gene predicted gene, 33655 Neighboring gene predicted gene 12829 Neighboring gene RIKEN cDNA 9130410C08 gene Neighboring gene STARR-seq mESC enhancer starr_11104 Neighboring gene predicted gene 12830

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Wnt-protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables Wnt-protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables Wnt-protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metalloendopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metalloendopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein oxidation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein-containing complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in organelle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in organelle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in organelle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    metalloprotease TIKI2
    Names
    TRAB domain-containing protein 2B
    UPF0632 protein A
    heart, kidney and adipose-enriched transmembrane protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085549.1NP_001079018.1  metalloprotease TIKI2 precursor

      See identical proteins and their annotated locations for NP_001079018.1

      Status: PROVISIONAL

      Source sequence(s)
      AL646006, AL670175
      Consensus CDS
      CCDS38843.1
      UniProtKB/Swiss-Prot
      B1ATG9
      Related
      ENSMUSP00000092494.4, ENSMUST00000094894.4
      Conserved Domains (1) summary
      pfam01963
      Location:41348
      TraB; TraB family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      114263394..114472295
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503276.5XP_006503339.1  metalloprotease TIKI2 isoform X1

      Conserved Domains (1) summary
      cd14789
      Location:3128
      Tiki; Tiki homology domain antagonizes Wnt function via cleavage of amino-terminal residues

    RNA

    1. XR_004941947.1 RNA Sequence

    2. XR_004941946.1 RNA Sequence