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    Odc1 ornithine decarboxylase, structural 1 [ Mus musculus (house mouse) ]

    Gene ID: 18263, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Odc1provided by MGI
    Official Full Name
    ornithine decarboxylase, structural 1provided by MGI
    Primary source
    MGI:MGI:97402
    See related
    Ensembl:ENSMUSG00000011179 AllianceGenome:MGI:97402
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ODC
    Summary
    Enables ornithine decarboxylase activity and protein homodimerization activity. Involved in putrescine biosynthetic process from ornithine and regulation of protein catabolic process. Acts upstream of or within kidney development and positive regulation of cell population proliferation. Located in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and sensory organ. Used to study atrichia with papular lesions. Orthologous to human ODC1 (ornithine decarboxylase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver E14 (RPKM 226.2), liver E14.5 (RPKM 221.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Odc1 in Genome Data Viewer
    Location:
    12 A1.1- A1.2; 12 8.11 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (17594906..17601503)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (17544808..17551502)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36752 Neighboring gene STARR-positive B cell enhancer mm9_chr12:17460788-17461088 Neighboring gene STARR-seq mESC enhancer starr_31660 Neighboring gene STARR-seq mESC enhancer starr_31661 Neighboring gene predicted gene, 46325 Neighboring gene STARR-positive B cell enhancer mm9_chr12:17513963-17514264 Neighboring gene STARR-positive B cell enhancer ABC_E9385 Neighboring gene predicted gene, 22748 Neighboring gene predicted gene, 36862 Neighboring gene predicted gene, 29864

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ornithine decarboxylase (ODC) expression pattern in human prostate tissues and ODC transgenic mice. Young L, et al. J Histochem Cytochem, 2006 Feb. PMID 16234506
    2. Ornithine decarboxylase is directly involved in mouse mammary carcinoma cell invasion in vitro. Kubota S, et al. Biochem Biophys Res Commun, 1995 Mar 28. PMID 7702610
    3. Elevated epidermal ornithine decarboxylase activity suppresses contact hypersensitivity. Keough MP, et al. J Invest Dermatol, 2011 Jan. PMID 20844550, Free PMC Article
    4. Differential transcription and expression of ornithine decarboxylase in embryos of replicated mouse lines divergently selected for lean body mass. Gray A, et al. Biochem J, 1995 May 15. PMID 7755561, Free PMC Article
    5. Gly387 of murine ornithine decarboxylase is essential for the formation of stable homodimers. Tobias KE, et al. Eur J Biochem, 1993 Nov 15. PMID 8243470

    See all (157) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Long-term inhibition of ODC1 in APP/PS1 mice rescues amyloid pathology and switches astrocytes from a reactive to active state.
      Title: Long-term inhibition of ODC1 in APP/PS1 mice rescues amyloid pathology and switches astrocytes from a reactive to active state.
    2. Ornithine decarboxylase, the rate-limiting enzyme of polyamine synthesis, modifies brain pathology in a mouse model of tuberous sclerosis complex.
      Title: Ornithine decarboxylase, the rate-limiting enzyme of polyamine synthesis, modifies brain pathology in a mouse model of tuberous sclerosis complex.
    3. ODC (Ornithine Decarboxylase)-Dependent Putrescine Synthesis Maintains MerTK (MER Tyrosine-Protein Kinase) Expression to Drive Resolution.
      Title: ODC (Ornithine Decarboxylase)-Dependent Putrescine Synthesis Maintains MerTK (MER Tyrosine-Protein Kinase) Expression to Drive Resolution.
    4. Amyloid beta may contribute to M1-like activation by disrupting the balance between ODC and AZ in microglia.
      Title: Aβ stimulates microglial activation through antizyme-dependent downregulation of ornithine decarboxylase.
    5. Findings indicated that ornithine decarboxylase (ODC1) was involved in attenuating the inflammatory response upon stimulation of macrophages, making it a potential therapeutic target for inflammatory diseases.
      Title: ODC1 inhibits the inflammatory response and ROS-induced apoptosis in macrophages.
    6. We demonstrate that ornithine decarboxylase (ODC) regulates M1 activation during Helicobacter pylori and Citrobacter rodentium infection. Deletion of Odc in macrophages resulted in increased inflammation and decreased bacterial persistence in mouse models. The enhanced M1 response was due to alterations in histone modifications, resulting in changes in chromatin structure and up-regulated transcription.
      Title: Ornithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modifications.
    7. these data support the hypothesis that TTP plays a role in the post-transcriptional regulation of the ODC mRNA transcript.
      Title: Destabilization of the ornithine decarboxylase mRNA transcript by the RNA-binding protein tristetraprolin.
    8. Ornithine decarboxylase (ODC) plays a key role in prostate tumorigenesis and that the polyamine pathway is altered as early as high-grade prostate intraepithelial neoplasia (HGPIN).
      Title: Ornithine Decarboxylase Is Sufficient for Prostate Tumorigenesis via Androgen Receptor Signaling.
    9. the Myc-ODC axis plays a critical role in the cellular transformation induced by myeloproliferative neoplasm-associated JAK2 V617F mutant
      Title: Critical roles of Myc-ODC axis in the cellular transformation induced by myeloproliferative neoplasm-associated JAK2 V617F mutant.
    10. Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway.
      Title: Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway.
    Submit: New GeneRIF Correction See all GeneRIFs (28)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (5)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC103389

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ornithine decarboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ornithine decarboxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ornithine decarboxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within kidney development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in polyamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in putrescine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in putrescine biosynthetic process from ornithine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in putrescine biosynthetic process from ornithine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in putrescine biosynthetic process from ornithine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ornithine decarboxylase
    NP_001396552.1
    NP_001396553.1
    NP_001396556.1
    NP_001396557.1
    NP_001396558.1
    NP_001396560.1
    NP_001396561.1
    NP_001396562.1
    NP_001396563.1
    NP_001396564.1
    NP_001396565.1
    NP_001396566.1
    NP_001396567.1
    NP_001396568.1
    NP_001396569.1
    NP_001396570.1
    NP_001396571.1
    NP_001396572.1
    NP_001396573.1
    NP_001396574.1
    NP_038642.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001409623.1 → NP_001396552.1  ornithine decarboxylase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC163651
      UniProtKB/Swiss-Prot
      P00860, Q61997, Q61998, Q6PB87

    2. NM_001409624.1 → NP_001396553.1  ornithine decarboxylase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC163651
      UniProtKB/Swiss-Prot
      P00860, Q61997, Q61998, Q6PB87

    3. NM_001409627.1 → NP_001396556.1  ornithine decarboxylase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC163651
      UniProtKB/Swiss-Prot
      P00860, Q61997, Q61998, Q6PB87

    4. NM_001409628.1 → NP_001396557.1  ornithine decarboxylase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC163651
      UniProtKB/Swiss-Prot
      P00860, Q61997, Q61998, Q6PB87

    5. NM_001409629.1 → NP_001396558.1  ornithine decarboxylase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC163651
      UniProtKB/Swiss-Prot
      P00860, Q61997, Q61998, Q6PB87

    6. NM_001409631.1 → NP_001396560.1  ornithine decarboxylase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC163651
      UniProtKB/Swiss-Prot
      P00860, Q61997, Q61998, Q6PB87

    7. NM_001409632.1 → NP_001396561.1  ornithine decarboxylase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC163651
      UniProtKB/Swiss-Prot
      P00860, Q61997, Q61998, Q6PB87

    8. NM_001409633.1 → NP_001396562.1  ornithine decarboxylase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC163651
      UniProtKB/Swiss-Prot
      P00860, Q61997, Q61998, Q6PB87

    9. NM_001409634.1 → NP_001396563.1  ornithine decarboxylase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC163651
      UniProtKB/Swiss-Prot
      P00860, Q61997, Q61998, Q6PB87

    10. NM_001409635.1 → NP_001396564.1  ornithine decarboxylase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC163651
      UniProtKB/Swiss-Prot
      P00860, Q61997, Q61998, Q6PB87

    11. NM_001409636.1 → NP_001396565.1  ornithine decarboxylase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC163651
      UniProtKB/Swiss-Prot
      P00860, Q61997, Q61998, Q6PB87

    12. NM_001409637.1 → NP_001396566.1  ornithine decarboxylase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC163651

    13. NM_001409638.1 → NP_001396567.1  ornithine decarboxylase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC163651

    14. NM_001409639.1 → NP_001396568.1  ornithine decarboxylase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC163651

    15. NM_001409640.1 → NP_001396569.1  ornithine decarboxylase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC163651

    16. NM_001409641.1 → NP_001396570.1  ornithine decarboxylase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC163651

    17. NM_001409642.1 → NP_001396571.1  ornithine decarboxylase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC163651

    18. NM_001409643.1 → NP_001396572.1  ornithine decarboxylase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC163651

    19. NM_001409644.1 → NP_001396573.1  ornithine decarboxylase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC163651

    20. NM_001409645.1 → NP_001396574.1  ornithine decarboxylase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC163651

    21. NM_013614.3 → NP_038642.2  ornithine decarboxylase isoform 1

      See identical proteins and their annotated locations for NP_038642.2

      Status: VALIDATED

      Source sequence(s)
      AC163651
      Consensus CDS
      CCDS25829.1
      UniProtKB/Swiss-Prot
      P00860, Q61997, Q61998, Q6PB87
      UniProtKB/TrEMBL
      Q3TM76
      Related
      ENSMUSP00000128661.2, ENSMUST00000171737.3
      Conserved Domains (1) summary
      cd00622
      Location:37 → 408
      PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      17594906..17601503
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001409630.1: Suppressed sequence

      Description
      NM_001409630.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P00860.2 GenPept UniProtKB/Swiss-Prot:P00860

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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