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    Mcur1 mitochondrial calcium uniporter regulator 1 [ Mus musculus (house mouse) ]

    Gene ID: 76137, updated on 27-Nov-2024

    Summary

    Official Symbol
    Mcur1provided by MGI
    Official Full Name
    mitochondrial calcium uniporter regulator 1provided by MGI
    Primary source
    MGI:MGI:1923387
    See related
    Ensembl:ENSMUSG00000021371 AllianceGenome:MGI:1923387
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ccdc90a; 6230416A05Rik
    Summary
    Predicted to be involved in calcium import into the mitochondrion; calcium ion import; and positive regulation of mitochondrial calcium ion concentration. Predicted to be active in mitochondrial inner membrane. Is expressed in brain; heart; and liver. Orthologous to human MCUR1 (mitochondrial calcium uniporter regulator 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 29.7), adrenal adult (RPKM 20.4) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Mcur1 in Genome Data Viewer
    Location:
    13 A4; 13 21.6 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (43691882..43714284, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (43538406..43560344, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene non-histone chromosomal protein HMG-17 pseudogene Neighboring gene predicted gene, 32939 Neighboring gene STARR-seq mESC enhancer starr_34344 Neighboring gene ring finger protein 182 Neighboring gene STARR-seq mESC enhancer starr_34345 Neighboring gene predicted gene, 52070

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in calcium import into the mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in calcium import into the mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium import into the mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in calcium ion import ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium ion import ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitochondrial calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrial calcium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of mitochondrial calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of mitochondrial calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitochondrial calcium ion concentration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    mitochondrial calcium uniporter regulator 1
    Names
    MCU regulator 1
    coiled-coil domain containing 90A
    coiled-coil domain-containing protein 90A, mitochondrial
    NP_001074528.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081059.3NP_001074528.1  mitochondrial calcium uniporter regulator 1

      See identical proteins and their annotated locations for NP_001074528.1

      Status: VALIDATED

      Source sequence(s)
      AC124171, AK018089, AK041849, BQ174175
      Consensus CDS
      CCDS36645.1
      UniProtKB/Swiss-Prot
      Q14DH8, Q3V3D3, Q9CXD6
      Related
      ENSMUSP00000021800.5, ENSMUST00000021800.6
      Conserved Domains (1) summary
      pfam07798
      Location:147338
      DUF1640; Protein of unknown function (DUF1640)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      43691882..43714284 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_001780828.3 RNA Sequence

    2. XR_003950490.2 RNA Sequence