Adamts6 ADAM metallopeptidase with thrombospondin type 1 motif 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adamts6provided by MGI
Official Full Name: ADAM metallopeptidase with thrombospondin type 1 motif 6provided by MGI
Primary source: MGI:MGI:1347348
See related: Ensembl:ENSMUSG00000046169 AllianceGenome:MGI:1347348
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ADAM-TS6; b2b2029Clo; b2b2182Clo; b2b2228Clo; b2b1879.1Clo; b2b2187.1Clo; A930019D11Rik
Summary: Predicted to enable metalloendopeptidase activity. Acts upstream of or within circulatory system development and kidney development. Predicted to be active in extracellular matrix. Is expressed in embryo. Orthologous to human ADAMTS6 (ADAM metallopeptidase with thrombospondin type 1 motif 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in limb E14.5 (RPKM 4.5), bladder adult (RPKM 3.5) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 D1; 13 56.42 cM

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (104423026..104633203)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (104286518..104496695)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (9)
Endonuclease-mediated (1)

General gene information

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Markers

Adamts6 (e-PCR), detects polymorphism
- UniSTS:532653

D13Mit51 (e-PCR), detects polymorphism
- UniSTS:127151

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within aorta development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardiac septum development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within coronary vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: A disintegrin and metalloproteinase with thrombospondin motifs 6

Names: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081020.2 → NP_001074489.1 A disintegrin and metalloproteinase with thrombospondin motifs 6 precursor

See identical proteins and their annotated locations for NP_001074489.1

Status: VALIDATED

Source sequence(s)

AC154830, AK030315, AK034499, AK044528

Consensus CDS

CCDS36773.1

UniProtKB/TrEMBL

D3Z1A5

Related

ENSMUSP00000064570.7, ENSMUST00000065766.7

Conserved Domains (6) summary

smart00209
Location:561 → 613

TSP1; Thrombospondin type 1 repeats

cd04273
Location:250 → 465

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01562
Location:43 → 191

Pep_M12B_propep; Reprolysin family propeptide

pfam05986
Location:719 → 829

ADAM_spacer1; ADAM-TS Spacer 1

pfam08686
Location:1083 → 1115

PLAC; PLAC (protease and lacunin) domain

pfam17771
Location:480 → 548

ADAM_CR_2; ADAM cysteine-rich domain

RNA

NR_136938.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC154830, AC165950, AK030315, AK034499, AK044528

Related

ENSMUST00000224784.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

104423026..104633203

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006517516.2 → XP_006517579.1 A disintegrin and metalloproteinase with thrombospondin motifs 6 isoform X1

Conserved Domains (6) summary

smart00209
Location:182 → 234

TSP1; Thrombospondin type 1 repeats

pfam05986
Location:340 → 450

ADAM_spacer1; ADAM-TS Spacer 1

pfam08686
Location:704 → 736

PLAC; PLAC (protease and lacunin) domain

pfam17771
Location:101 → 169

ADAM_CR_2; ADAM cysteine-rich domain

pfam19030
Location:465 → 520

TSP1_ADAMTS; Thrombospondin type 1 domain

cl00064
Location:1 → 86

ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
XM_036157826.1 → XP_036013719.1 A disintegrin and metalloproteinase with thrombospondin motifs 6 isoform X3

Conserved Domains (6) summary

smart00209
Location:182 → 234

TSP1; Thrombospondin type 1 repeats

pfam05986
Location:258 → 364

ADAM_spacer1; ADAM-TS Spacer 1

pfam08686
Location:618 → 650

PLAC; PLAC (protease and lacunin) domain

pfam17771
Location:101 → 169

ADAM_CR_2; ADAM cysteine-rich domain

pfam19030
Location:379 → 434

TSP1_ADAMTS; Thrombospondin type 1 domain

cl00064
Location:1 → 86

ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
XM_030247122.1 → XP_030102982.1 A disintegrin and metalloproteinase with thrombospondin motifs 6 isoform X4

Conserved Domains (4) summary

smart00209
Location:71 → 123

TSP1; Thrombospondin type 1 repeats

pfam05986
Location:229 → 339

ADAM_spacer1; ADAM-TS Spacer 1

pfam08686
Location:593 → 625

PLAC; PLAC (protease and lacunin) domain

pfam17771
Location:10 → 58

ADAM_CR_2; ADAM cysteine-rich domain
XM_036157825.1 → XP_036013718.1 A disintegrin and metalloproteinase with thrombospondin motifs 6 isoform X2

Conserved Domains (6) summary

smart00209
Location:151 → 203

TSP1; Thrombospondin type 1 repeats

pfam05986
Location:309 → 419

ADAM_spacer1; ADAM-TS Spacer 1

pfam08686
Location:673 → 705

PLAC; PLAC (protease and lacunin) domain

pfam17771
Location:70 → 138

ADAM_CR_2; ADAM cysteine-rich domain

pfam19030
Location:434 → 489

TSP1_ADAMTS; Thrombospondin type 1 domain

cl00064
Location:1 → 55

ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
XM_011244611.3 → XP_011242913.1 A disintegrin and metalloproteinase with thrombospondin motifs 6 isoform X5

See identical proteins and their annotated locations for XP_011242913.1

UniProtKB/TrEMBL

D3Z1A5

Conserved Domains (6) summary

smart00209
Location:561 → 613

TSP1; Thrombospondin type 1 repeats

cd04273
Location:250 → 465

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01562
Location:43 → 191

Pep_M12B_propep; Reprolysin family propeptide

pfam05986
Location:719 → 829

ADAM_spacer1; ADAM-TS Spacer 1

pfam08686
Location:1083 → 1115

PLAC; PLAC (protease and lacunin) domain

pfam17771
Location:480 → 548

ADAM_CR_2; ADAM cysteine-rich domain
XM_030247120.1 → XP_030102980.1 A disintegrin and metalloproteinase with thrombospondin motifs 6 isoform X1

Conserved Domains (6) summary

smart00209
Location:182 → 234

TSP1; Thrombospondin type 1 repeats

pfam05986
Location:340 → 450

ADAM_spacer1; ADAM-TS Spacer 1

pfam08686
Location:704 → 736

PLAC; PLAC (protease and lacunin) domain

pfam17771
Location:101 → 169

ADAM_CR_2; ADAM cysteine-rich domain

pfam19030
Location:465 → 520

TSP1_ADAMTS; Thrombospondin type 1 domain

cl00064
Location:1 → 86

ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
XM_036157824.1 → XP_036013717.1 A disintegrin and metalloproteinase with thrombospondin motifs 6 isoform X1

Conserved Domains (6) summary

smart00209
Location:182 → 234

TSP1; Thrombospondin type 1 repeats

pfam05986
Location:340 → 450

ADAM_spacer1; ADAM-TS Spacer 1

pfam08686
Location:704 → 736

PLAC; PLAC (protease and lacunin) domain

pfam17771
Location:101 → 169

ADAM_CR_2; ADAM cysteine-rich domain

pfam19030
Location:465 → 520

TSP1_ADAMTS; Thrombospondin type 1 domain

cl00064
Location:1 → 86

ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
XM_030247121.2 → XP_030102981.1 A disintegrin and metalloproteinase with thrombospondin motifs 6 isoform X1

Conserved Domains (6) summary

smart00209
Location:182 → 234

TSP1; Thrombospondin type 1 repeats

pfam05986
Location:340 → 450

ADAM_spacer1; ADAM-TS Spacer 1

pfam08686
Location:704 → 736

PLAC; PLAC (protease and lacunin) domain

pfam17771
Location:101 → 169

ADAM_CR_2; ADAM cysteine-rich domain

pfam19030
Location:465 → 520

TSP1_ADAMTS; Thrombospondin type 1 domain

cl00064
Location:1 → 86

ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
XM_006517517.3 → XP_006517580.1 A disintegrin and metalloproteinase with thrombospondin motifs 6 isoform X4

Conserved Domains (4) summary

smart00209
Location:71 → 123

TSP1; Thrombospondin type 1 repeats

pfam05986
Location:229 → 339

ADAM_spacer1; ADAM-TS Spacer 1

pfam08686
Location:593 → 625

PLAC; PLAC (protease and lacunin) domain

pfam17771
Location:10 → 58

ADAM_CR_2; ADAM cysteine-rich domain

RNA

XR_003950407.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_175496.2: Suppressed sequence

Description

NM_175496.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.