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    Ino80d INO80 complex subunit D [ Mus musculus (house mouse) ]

    Gene ID: 227195, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ino80dprovided by MGI
    Official Full Name
    INO80 complex subunit Dprovided by MGI
    Primary source
    MGI:MGI:3027003
    See related
    Ensembl:ENSMUSG00000040865 AllianceGenome:MGI:3027003
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    7330405I11; A430093A21Rik
    Summary
    Involved in positive regulation of DNA metabolic process; regulation of embryonic development; and telomere maintenance. Predicted to be part of Ino80 complex. Predicted to be active in nucleus. Is expressed in several structures, including endocrine gland; gallbladder; genitourinary system; nervous system; and skeletal muscle tissue. Orthologous to human INO80D (INO80 complex subunit D). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 7.5), lung adult (RPKM 4.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ino80d in Genome Data Viewer
    Location:
    1 C2; 1 31.89 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (63086960..63153693, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (63047801..63114267, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 44468 Neighboring gene predicted gene, 24942 Neighboring gene ribosomal protein S27, pseudogene 1 Neighboring gene STARR-positive B cell enhancer ABC_E2545 Neighboring gene STARR-seq mESC enhancer starr_01125 Neighboring gene INO80 complex subunit D, opposite strand Neighboring gene STARR-seq mESC enhancer starr_01129 Neighboring gene NADH:ubiquinone oxidoreductase core subunit S1 Neighboring gene STARR-positive B cell enhancer ABC_E1994 Neighboring gene predicted gene, 26457 Neighboring gene eukaryotic translation elongation factor 1 beta 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The mINO80 chromatin remodeling complex is required for efficient telomere replication and maintenance of genome stability. Min JN, et al. Cell Res, 2013 Dec. PMID 23979016, Free PMC Article
    2. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of telomere maintenance in response to DNA damage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA strand elongation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of chromosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Ino80 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    INO80 complex subunit D

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081436.3 → NP_001074905.1  INO80 complex subunit D isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate splice site, which results in a downstream AUG start codon, as compared to variant 1. The resulting isoform (2) has a shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AL645685, AL645950
      Consensus CDS
      CCDS35594.1
      UniProtKB/TrEMBL
      B1AT32
      Related
      ENSMUSP00000115332.3, ENSMUST00000153992.3
      Conserved Domains (2) summary
      PRK14971
      Location:65 → 195
      PRK14971; DNA polymerase III subunit gamma/tau
      pfam13891
      Location:337 → 401
      zf-C3Hc3H; Potential DNA-binding domain

    2. NM_001114609.2 → NP_001108081.1  INO80 complex subunit D isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longer transcript and encodes the longer isoform.
      Source sequence(s)
      AL645685, AL645950
      Consensus CDS
      CCDS48277.1
      UniProtKB/Swiss-Prot
      E9Q9Q0, E9QLE8, Q66JY2, Q8BQK5
      Related
      ENSMUSP00000119118.3, ENSMUST00000137511.9
      Conserved Domains (2) summary
      PRK14971
      Location:170 → 300
      PRK14971; DNA polymerase III subunit gamma/tau
      pfam13891
      Location:18 → 79
      zf-C3Hc3H; Potential DNA-binding domain

    3. NM_001406701.1 → NP_001393630.1  INO80 complex subunit D isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL645685, AL645950
      UniProtKB/Swiss-Prot
      E9Q9Q0, E9QLE8, Q66JY2, Q8BQK5

    4. NM_001406702.1 → NP_001393631.1  INO80 complex subunit D isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL645685, AL645950
      UniProtKB/Swiss-Prot
      E9Q9Q0, E9QLE8, Q66JY2, Q8BQK5

    5. NM_001406703.1 → NP_001393632.1  INO80 complex subunit D isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL645685, AL645950
      UniProtKB/Swiss-Prot
      E9Q9Q0, E9QLE8, Q66JY2, Q8BQK5

    6. NM_001406704.1 → NP_001393633.1  INO80 complex subunit D isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL645685, AL645950
      UniProtKB/Swiss-Prot
      E9Q9Q0, E9QLE8, Q66JY2, Q8BQK5
      Related
      ENSMUSP00000095325.4, ENSMUST00000097718.10

    7. NM_001406705.1 → NP_001393634.1  INO80 complex subunit D isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL645685, AL645950
      UniProtKB/Swiss-Prot
      E9Q9Q0, E9QLE8, Q66JY2, Q8BQK5

    8. NM_001406706.1 → NP_001393635.1  INO80 complex subunit D isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL645685, AL645950
      UniProtKB/Swiss-Prot
      E9Q9Q0, E9QLE8, Q66JY2, Q8BQK5

    9. NM_001406707.1 → NP_001393636.1  INO80 complex subunit D isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL645685, AL645950
      UniProtKB/Swiss-Prot
      E9Q9Q0, E9QLE8, Q66JY2, Q8BQK5

    10. NM_001406708.1 → NP_001393637.1  INO80 complex subunit D isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL645685, AL645950
      UniProtKB/Swiss-Prot
      E9Q9Q0, E9QLE8, Q66JY2, Q8BQK5

    11. NM_001406709.1 → NP_001393638.1  INO80 complex subunit D isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL645685, AL645950
      UniProtKB/Swiss-Prot
      E9Q9Q0, E9QLE8, Q66JY2, Q8BQK5

    12. NM_001406710.1 → NP_001393639.1  INO80 complex subunit D isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL645685, AL645950
      UniProtKB/TrEMBL
      B1AT32

    13. NM_001406711.1 → NP_001393640.1  INO80 complex subunit D isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL645685, AL645950
      UniProtKB/TrEMBL
      B1AT32

    14. NM_001406712.1 → NP_001393641.1  INO80 complex subunit D isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL645685, AL645950
      UniProtKB/TrEMBL
      B1AT32
      Related
      ENSMUSP00000123430.2, ENSMUST00000133236.8

    15. NM_001406713.1 → NP_001393642.1  INO80 complex subunit D isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL645685, AL645950
      UniProtKB/TrEMBL
      B1AT32

    16. NM_001406714.1 → NP_001393643.1  INO80 complex subunit D isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL645685, AL645950
      UniProtKB/TrEMBL
      B1AT32

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      63086960..63153693 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q66JY2.4 GenPept UniProtKB/Swiss-Prot:Q66JY2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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