Bpifc BPI fold containing family C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bpifcprovided by MGI
Official Full Name: BPI fold containing family Cprovided by MGI
Primary source: MGI:MGI:3026884
See related: Ensembl:ENSMUSG00000050108 AllianceGenome:MGI:3026884
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bpil2; 4732454E24
Summary: Predicted to enable lipid binding activity. Predicted to be involved in innate immune response. Predicted to be active in extracellular space. Orthologous to human BPIFC (BPI fold containing family C). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in stomach adult (RPKM 1.7), limb E14.5 (RPKM 1.0) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 41.83 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (85795555..85847724, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (85959691..86011860, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:487528

BB370606 (e-PCR)
- UniSTS:208583

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: BPI fold-containing family C protein

Names: bactericidal/permeability-increasing protein-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177772.4 → NP_808440.2 BPI fold-containing family C protein precursor

See identical proteins and their annotated locations for NP_808440.2

Status: VALIDATED

Source sequence(s)

AK028764, BB527461, BC112376, BY142313

Consensus CDS

CCDS48658.1

UniProtKB/Swiss-Prot

Q8C186

UniProtKB/TrEMBL

Q3V1D7

Related

ENSMUSP00000063107.6, ENSMUST00000061699.12

Conserved Domains (2) summary

pfam01273
Location:38 → 202

LBP_BPI_CETP; LBP / BPI / CETP family, N-terminal domain

cl00188
Location:242 → 478

BPI; BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative ...