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    Zdhhc8 zinc finger, DHHC domain containing 8 [ Mus musculus (house mouse) ]

    Gene ID: 27801, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zdhhc8provided by MGI
    Official Full Name
    zinc finger, DHHC domain containing 8provided by MGI
    Primary source
    MGI:MGI:1338012
    See related
    Ensembl:ENSMUSG00000060166 AllianceGenome:MGI:1338012
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DHHC-8; Op53c05; ZDHHCL1; D16H22S1738E; E330009O14Rik
    Summary
    Predicted to enable palmitoyltransferase activity. Involved in regulation of postsynapse assembly. Acts upstream of or within locomotory behavior. Located in mitochondrion. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including brain; cardiovascular system; forelimb bud; ganglia; and nose. Orthologous to human ZDHHC8 (zinc finger DHHC-type palmitoyltransferase 8). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 67.5), ovary adult (RPKM 44.5) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zdhhc8 in Genome Data Viewer
    Location:
    16 A3; 16 11.29 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (18038612..18056471, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (18220748..18235153, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4933432I09 gene Neighboring gene coiled-coil domain containing 188 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:18231149-18231350 Neighboring gene predicted gene, 25777 Neighboring gene RAN binding protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E8621 Neighboring gene TRM2 tRNA methyltransferase 2A Neighboring gene DGCR8, microprocessor complex subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Hippocampal-prefrontal theta-gamma coupling during performance of a spatial working memory task. Tamura M, et al. Nat Commun, 2017 Dec 19. PMID 29259151, Free PMC Article
    2. Molecular substrates of altered axonal growth and brain connectivity in a mouse model of schizophrenia. Mukai J, et al. Neuron, 2015 May 6. PMID 25913858, Free PMC Article
    3. Palmitoylation-dependent neurodevelopmental deficits in a mouse model of 22q11 microdeletion. Mukai J, et al. Nat Neurosci, 2008 Nov. PMID 18836441, Free PMC Article
    4. Ankyrin-G palmitoylation and βII-spectrin binding to phosphoinositide lipids drive lateral membrane assembly. He M, et al. J Cell Biol, 2014 Jul 21. PMID 25049274, Free PMC Article
    5. S-nitrosylation and S-palmitoylation reciprocally regulate synaptic targeting of PSD-95. Ho GP, et al. Neuron, 2011 Jul 14. PMID 21745643, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC7847, MGC103030, MGC118171

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables palmitoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-cysteine S-palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptidyl-L-cysteine S-palmitoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-L-cysteine S-palmitoylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation by host of viral process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation by host of viral process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cholesterol efflux IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cholesterol efflux ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cholesterol efflux ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within protein palmitoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein palmitoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of postsynapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynapse IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    palmitoyltransferase ZDHHC8
    Names
    DHHC-containing protein 8
    probable palmitoyltransferase ZDHHC8
    zinc finger DHHC domain-containing protein 8
    NP_001365948.1
    NP_742163.4
    XP_006522287.1
    XP_036015869.1
    XP_036015870.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001379019.1 → NP_001365948.1  palmitoyltransferase ZDHHC8 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC084822, AC118542
      UniProtKB/TrEMBL
      Q2TGE7
      Conserved Domains (1) summary
      pfam01529
      Location:99 → 224
      DHHC; DHHC palmitoyltransferase

    2. NM_172151.4 → NP_742163.4  palmitoyltransferase ZDHHC8 isoform 1

      See identical proteins and their annotated locations for NP_742163.4

      Status: VALIDATED

      Source sequence(s)
      AY668947, AY894892
      Consensus CDS
      CCDS28017.1
      UniProtKB/Swiss-Prot
      Q5Y5T5, Q7TNF7
      UniProtKB/TrEMBL
      Q2TGE7
      Related
      ENSMUSP00000076224.6, ENSMUST00000076957.7
      Conserved Domains (1) summary
      pfam01529
      Location:99 → 224
      zf-DHHC; DHHC palmitoyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      18038612..18056471 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522224.5 → XP_006522287.1  palmitoyltransferase ZDHHC8 isoform X1

      See identical proteins and their annotated locations for XP_006522287.1

      UniProtKB/TrEMBL
      Q2TGE7
      Conserved Domains (1) summary
      cl19890
      Location:28 → 171
      DHHC; DHHC palmitoyltransferase

    2. XM_036159976.1 → XP_036015869.1  palmitoyltransferase ZDHHC8 isoform X2

    3. XM_036159977.1 → XP_036015870.1  palmitoyltransferase ZDHHC8 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5Y5T5.1 GenPept UniProtKB/Swiss-Prot:Q5Y5T5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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