Apela apelin receptor early endogenous ligand [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Apelaprovided by MGI
Official Full Name: apelin receptor early endogenous ligandprovided by MGI
Primary source: MGI:MGI:3642370
See related: Ensembl:ENSMUSG00000079042 AllianceGenome:MGI:3642370
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ela; Ende; Elabela; Gm10664
Summary: Predicted to enable apelin receptor binding activity and hormone activity. Involved in circulatory system development and positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis. Acts upstream of or within regulation of blood pressure. Located in extracellular space. Is expressed in several structures, including embryo ectoderm; embryo endoderm; gut; heart; and metanephros. Used to study pre-eclampsia. Orthologous to human APELA (apelin receptor early endogenous ligand). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in kidney adult (RPKM 30.1), placenta adult (RPKM 5.1) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 8 B3.1; 8 32.52 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (65481069..65489970, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (65028417..65037336, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ELABELA/APJ Axis Prevents Diabetic Glomerular Endothelial Injury by Regulating AMPK/NLRP3 Pathway.
Title: ELABELA/APJ Axis Prevents Diabetic Glomerular Endothelial Injury by Regulating AMPK/NLRP3 Pathway.
Elabela-APJ axis mediates angiogenesis via YAP/TAZ pathway in cerebral ischemia/reperfusion injury.
Title: Elabela-APJ axis mediates angiogenesis via YAP/TAZ pathway in cerebral ischemia/reperfusion injury.
Apela inhibits systemic and renal inflammatory reactions in mice with type I cardiorenal syndrome.
Title: Apela inhibits systemic and renal inflammatory reactions in mice with type I cardiorenal syndrome.
Antagonistic interaction between ELA and intrarenal renin angiotensin system in the distal nephron that appears to exert a major impact on blood pressure regulation.
Title: ELABELA antagonizes intrarenal renin-angiotensin system to lower blood pressure and protects against renal injury.
loss of Apela signaling impacts early Aplnr-expressing mesodermal populations.
Title: Loss of Apela Peptide in Mice Causes Low Penetrance Embryonic Lethality and Defects in Early Mesodermal Derivatives.
Elabela but not Apelin knockout pregnant mice exhibit preeclampsia -like symptoms, including proteinuria and elevated blood pressure due to defective placental angiogenesis.
Title: ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice.
the ELABELA (ELA)-APJ signaling axis is only required for sinus venosus-derived progenitors.
Title: Alternative Progenitor Cells Compensate to Rebuild the Coronary Vasculature in Elabela- and Apj-Deficient Hearts.
conclude that apela is present in the adult heart, is upregulated in post-infarction cardiac remodeling, and increases cardiac contractility in an ERK1/2-dependent manner
Title: Characterization of apela, a novel endogenous ligand of apelin receptor, in the adult heart.
Ende was expressed dynamically and in specific populations of the definitive endoderm from E7.0 to E8.5.
Title: Expression of two novel transcripts in the mouse definitive endoderm.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7) 1 citation
Targeted (2) 1 citation

General gene information

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Markers

Gm10664 (e-PCR), detects polymorphism
- UniSTS:528628

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables apelin receptor binding	ISO Inferred from Sequence Orthology more info
enables apelin receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables hormone activity	ISO Inferred from Sequence Orthology more info
enables hormone activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in apelin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in apelin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell migration involved in mesendoderm migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in coronary vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic heart tube development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoderm development	ISS Inferred from Sequence or Structural Similarity more info
involved_in heart development	ISS Inferred from Sequence or Structural Similarity more info
involved_in mesendoderm migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in mesoderm migration involved in gastrulation	ISS Inferred from Sequence or Structural Similarity more info
involved_in placenta blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of G protein-coupled receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of heart contraction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of trophoblast cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of trophoblast cell migration	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vasculogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: apelin receptor early endogenous ligand

Names: Protein Elabela; protein Toddler

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001297554.2 → NP_001284483.1 apelin receptor early endogenous ligand precursor

See identical proteins and their annotated locations for NP_001284483.1

Status: VALIDATED

Source sequence(s)

AC102287

Consensus CDS

CCDS80883.1

UniProtKB/Swiss-Prot

P0DMC4

Related

ENSMUSP00000140510.2, ENSMUST00000142822.4

Conserved Domains (1) summary

cd20244
Location:2 → 54

Toddler; Apelin receptor early endogenous ligand, also called Toddler
NM_001399422.1 → NP_001386351.1 apelin receptor early endogenous ligand precursor

Status: VALIDATED

Source sequence(s)

AC102287

UniProtKB/Swiss-Prot

P0DMC4

Related

ENSMUSP00000139425.2, ENSMUST00000124790.8

Conserved Domains (1) summary

cd20244
Location:2 → 54

Toddler; Apelin receptor early endogenous ligand, also called Toddler

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

65481069..65489970 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NR_040692.1: Suppressed sequence

Description

NR_040692.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.