Gpr15lg G protein coupled receptor 15 ligand [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gpr15lgprovided by MGI
Official Full Name: G protein coupled receptor 15 ligandprovided by MGI
Primary source: MGI:MGI:1917295
See related: Ensembl:ENSMUSG00000096001 AllianceGenome:MGI:1917295
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gpr15l; 2610528A11Rik
Summary: Enables chemokine activity. Involved in lymphocyte chemotaxis. Predicted to be located in extracellular region. Is expressed in tail unsegmented mesenchyme. Orthologous to human GPR15LG (G protein-coupled receptor 15 ligand). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in colon adult (RPKM 238.3) and testis adult (RPKM 26.0) See more
Orthologs: human all
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Genomic context

Location:: 14 B; 14 21.29 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (36824097..36832058, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (37102140..37110101, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GPR15LG regulates psoriasis-like inflammation by down-regulating inflammatory factors on keratinocytes.
Title: GPR15LG regulates psoriasis-like inflammation by down-regulating inflammatory factors on keratinocytes.
Allotransplantation of skin from Gpr15l-deficient mice onto wild-type mice resulted in substantial graft protection, suggesting nonredundant roles for GPR15 and GPR15L in the generation of effector T cell responses.
Title: A natural ligand for the orphan receptor GPR15 modulates lymphocyte recruitment to epithelia.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables chemokine activity	IDA Inferred from Direct Assay more info	PubMed
enables chemokine activity	ISO Inferred from Sequence Orthology more info
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in T cell homeostasis	IEA Inferred from Electronic Annotation more info
involved_in T cell homeostasis	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-positive bacterium	IEA Inferred from Electronic Annotation more info
involved_in defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to fungus	IEA Inferred from Electronic Annotation more info
involved_in defense response to fungus	ISO Inferred from Sequence Orthology more info
involved_in lymphocyte chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in lymphocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in mast cell degranulation	ISO Inferred from Sequence Orthology more info
involved_in mast cell degranulation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell cycle G1/S phase transition	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell cycle G1/S phase transition	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell division	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell division	ISO Inferred from Sequence Orthology more info
involved_in regulation of T cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of T cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of keratinocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of keratinocyte proliferation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein GPR15LG

Names: protein GPR15 ligand; protein GPR15L; secreted protein C10orf99 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.