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    Urb2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae) [ Mus musculus (house mouse) ]

    Gene ID: 382038, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Urb2provided by MGI
    Official Full Name
    URB2 ribosome biogenesis 2 homolog (S. cerevisiae)provided by MGI
    Primary source
    MGI:MGI:2681124
    See related
    Ensembl:ENSMUSG00000031976 AllianceGenome:MGI:2681124
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0133
    Summary
    Predicted to be involved in ribosome biogenesis. Predicted to be located in aggresome and midbody. Predicted to be active in nucleolus. Is expressed in glossopharyngeal ganglion and trigeminal ganglion. Orthologous to human URB2 (URB2 ribosome biogenesis homolog). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 13.3), thymus adult (RPKM 5.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Urb2 in Genome Data Viewer
    Location:
    8 E2; 8 72.33 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (124748236..124775244)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (124021497..124048505)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette, sub-family B member 10 Neighboring gene predicted gene, 53469 Neighboring gene STARR-seq mESC enhancer starr_22990 Neighboring gene TATA-box binding protein associated factor 5 like Neighboring gene STARR-seq mESC enhancer starr_22991 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene microRNA 1967 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:126581223-126581424 Neighboring gene predicted gene, 29897 Neighboring gene predicted gene, 30005

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
    2. ALS-linked loss of Cyclin-F function affects HSP90. Siebert A, et al. Life Sci Alliance, 2022 Sep 16. PMID 36114006, Free PMC Article
    3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0133

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in ribosome biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in aggresome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    unhealthy ribosome biogenesis protein 2 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001029876.2 → NP_001025047.1  unhealthy ribosome biogenesis protein 2 homolog

      See identical proteins and their annotated locations for NP_001025047.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC139575
      Consensus CDS
      CCDS22768.1
      UniProtKB/TrEMBL
      B9EKU4, E9Q7L1
      Conserved Domains (1) summary
      pfam10441
      Location:1321 → 1516
      Urb2; Urb2/Npa2 family

    2. NM_001368414.1 → NP_001355343.1  unhealthy ribosome biogenesis protein 2 homolog

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC139575
      Consensus CDS
      CCDS22768.1
      UniProtKB/TrEMBL
      B9EKU4, E9Q7L1
      Related
      ENSMUSP00000034457.9, ENSMUST00000034457.9
      Conserved Domains (1) summary
      pfam10441
      Location:1321 → 1516
      Urb2; Urb2/Npa2 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      124748236..124775244
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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