Fbxl5 F-box and leucine-rich repeat protein 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fbxl5provided by MGI
Official Full Name: F-box and leucine-rich repeat protein 5provided by MGI
Primary source: MGI:MGI:2152883
See related: Ensembl:ENSMUSG00000039753 AllianceGenome:MGI:2152883
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fbl4; Fir4
Summary: Predicted to enable iron ion binding activity. Acts upstream of or within multicellular organismal-level iron ion homeostasis and positive regulation of protein catabolic process. Predicted to be located in perinuclear region of cytoplasm. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in several structures, including central nervous system; eye; genitourinary system; hemolymphoid system gland; and liver. Orthologous to human FBXL5 (F-box and leucine rich repeat protein 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in cerebellum adult (RPKM 17.0), placenta adult (RPKM 16.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 B3; 5 23.81 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (43901958..43939529, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (43744618..43782149, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FBXL5 promotes lipid accumulation in alcoholic fatty liver disease by promoting the ubiquitination and degradation of TFEB.
Title: FBXL5 promotes lipid accumulation in alcoholic fatty liver disease by promoting the ubiquitination and degradation of TFEB.
Role of FBXL5 in redox homeostasis and spindle assembly during oocyte maturation in mice.
Title: Role of FBXL5 in redox homeostasis and spindle assembly during oocyte maturation in mice.
FBXL5-deficient mice are the first genetically engineered mouse model of liver carcinogenesis promoted by iron overload.
Title: Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis.
Increased intracellular growth due to compromised expressions of Fpn and FBXL5 by specific siRNAs reveals that Leishmania donovani uses a novel strategy of manipulating IRP2-FBXL5 axis to inhibit host Fpn expression.
Title: Leishmania donovani inhibits ferroportin translation by modulating FBXL5-IRP2 axis for its growth within host macrophages.
Conditional deletion of Fbxl5 in mouse HSCs results in cellular iron overload and a reduced cell number. Bone marrow transplantation reveals that FBXL5-deficient HSCs are unable to reconstitute the hematopoietic system of irradiated recipients as a result of stem cell exhaustion. Transcriptomic analysis shows abnormal activation of oxidative stress responses and the cell cycle in FBXL5-deficient mouse HSCs.
Title: Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells.
FBXL5 contributes to regulation of neural stem progenitor cell proliferation during mammalian brain development.
Title: FBXL5 Inactivation in Mouse Brain Induces Aberrant Proliferation of Neural Stem Progenitor Cells.
we describe the iron and oxygen sensing mechanisms of the FBXL5 Hr-like domain and its role in mediating ROS biology.
Title: F-box and leucine-rich repeat protein 5 (FBXL5): sensing intracellular iron and oxygen.
F-box and leucine-rich repeat protein 5 (FBXL5) is required for maintenance of cellular and systemic iron homeostasis
Title: F-box and leucine-rich repeat protein 5 (FBXL5) is required for maintenance of cellular and systemic iron homeostasis.
The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo.
Title: The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (2)
Gene trapped (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables iron ion binding	ISO Inferred from Sequence Orthology more info
enables iron ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular iron ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular iron ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SCF ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of SCF ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: F-box/LRR-repeat protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159963.2 → NP_001153435.1 F-box/LRR-repeat protein 5 isoform A

See identical proteins and their annotated locations for NP_001153435.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (A).

Source sequence(s)

AC140277

Consensus CDS

CCDS51489.1

UniProtKB/Swiss-Prot

Q14CG1, Q3TAK6, Q3TWC9, Q3UC66, Q80XI5, Q8BGF5, Q8BNL3, Q8C2S5, Q8C3Q8

UniProtKB/TrEMBL

F7BZC4

Related

ENSMUSP00000045792.10, ENSMUST00000047857.16

Conserved Domains (4) summary

cd09293
Location:340 → 404

AMN1; Antagonist of mitotic exit network protein 1

cd12109
Location:7 → 160

Hr_FBXL5; Hemerythrin-like domain of FBXL5-like proteins

sd00034
Location:358 → 384

LRR_AMN1; leucine-rich repeat [structural motif]

pfam12937
Location:205 → 249

F-box-like; F-box-like
NM_001424600.1 → NP_001411529.1 F-box/LRR-repeat protein 5 isoform 3

Status: VALIDATED

Source sequence(s)

AC140277
NM_001424602.1 → NP_001411531.1 F-box/LRR-repeat protein 5 isoform 4

Status: VALIDATED

Source sequence(s)

AC140277
NM_001424604.1 → NP_001411533.1 F-box/LRR-repeat protein 5 isoform 5

Status: VALIDATED

Source sequence(s)

AC140277

Related

ENSMUSP00000143703.2, ENSMUST00000196483.5
NM_001424605.1 → NP_001411534.1 F-box/LRR-repeat protein 5 isoform 6

Status: VALIDATED

Source sequence(s)

AC140277
NM_001424606.1 → NP_001411535.1 F-box/LRR-repeat protein 5 isoform 7

Status: VALIDATED

Source sequence(s)

AC140277
NM_001424607.1 → NP_001411536.1 F-box/LRR-repeat protein 5 isoform 8

Status: VALIDATED

Source sequence(s)

AC140277

Related

ENSMUSP00000109681.4, ENSMUST00000114047.10
NM_001424608.1 → NP_001411537.1 F-box/LRR-repeat protein 5 isoform 9

Status: VALIDATED

Source sequence(s)

AC140277

UniProtKB/TrEMBL

D3Z584

Related

ENSMUSP00000113557.2, ENSMUST00000119523.8
NM_001424609.1 → NP_001411538.1 F-box/LRR-repeat protein 5 isoform 10

Status: VALIDATED

Source sequence(s)

AC140277
NM_001424610.1 → NP_001411539.1 F-box/LRR-repeat protein 5 isoform 11

Status: VALIDATED

Source sequence(s)

AC140277
NM_001424611.1 → NP_001411540.1 F-box/LRR-repeat protein 5 isoform 12

Status: VALIDATED

Source sequence(s)

AC140277
NM_001424612.1 → NP_001411541.1 F-box/LRR-repeat protein 5 isoform 13

Status: VALIDATED

Source sequence(s)

AC140277
NM_001424613.1 → NP_001411542.1 F-box/LRR-repeat protein 5 isoform 14

Status: VALIDATED

Source sequence(s)

AC140277
NM_001424614.1 → NP_001411543.1 F-box/LRR-repeat protein 5 isoform 15

Status: VALIDATED

Source sequence(s)

AC140277
NM_001424615.1 → NP_001411544.1 F-box/LRR-repeat protein 5 isoform 16

Status: VALIDATED

Source sequence(s)

AC140277
NM_001424616.1 → NP_001411545.1 F-box/LRR-repeat protein 5 isoform 17

Status: VALIDATED

Source sequence(s)

AC140277
NM_001424617.1 → NP_001411546.1 F-box/LRR-repeat protein 5 isoform 18

Status: VALIDATED

Source sequence(s)

AC140277
NM_001424618.1 → NP_001411547.1 F-box/LRR-repeat protein 5 isoform 19

Status: VALIDATED

Source sequence(s)

AC140277
NM_178729.5 → NP_848844.1 F-box/LRR-repeat protein 5 isoform B

See identical proteins and their annotated locations for NP_848844.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has a different 3' terminus, compared to variant 1, which results in a protein (isoform B) with a shorter and distinct C-terminus, compared to isoform A.

Source sequence(s)

AC140277

Consensus CDS

CCDS19263.1

UniProtKB/TrEMBL

F7BZC4

Related

ENSMUSP00000084733.5, ENSMUST00000087465.11

Conserved Domains (4) summary

cd09293
Location:340 → 404

AMN1; Antagonist of mitotic exit network protein 1

cd12109
Location:7 → 160

Hr_FBXL5; Hemerythrin-like domain of FBXL5-like proteins

sd00034
Location:333 → 357

LRR_AMN1; leucine-rich repeat [structural motif]

pfam12937
Location:205 → 249

F-box-like; F-box-like

RNA

NR_188801.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC140277
NR_188802.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC140277
NR_188803.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC140277

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

43901958..43939529 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036165123.1 → XP_036021016.1 F-box/LRR-repeat protein 5 isoform X1

UniProtKB/TrEMBL

F7BZC4

Conserved Domains (4) summary

cd09293
Location:340 → 404

AMN1; Antagonist of mitotic exit network protein 1

cd12109
Location:7 → 160

Hr_FBXL5; Hemerythrin-like domain of FBXL5-like proteins

sd00034
Location:358 → 384

LRR_AMN1; leucine-rich repeat [structural motif]

pfam12937
Location:205 → 249

F-box-like