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    Lcn9 lipocalin 9 [ Mus musculus (house mouse) ]

    Gene ID: 77704, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Lcn9provided by MGI
    Official Full Name
    lipocalin 9provided by MGI
    Primary source
    MGI:MGI:1924954
    See related
    Ensembl:ENSMUSG00000023210 AllianceGenome:MGI:1924954
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9230102I19Rik
    Summary
    Predicted to enable small molecule binding activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human LCN9 (lipocalin 9). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward genital fat pad adult (RPKM 720.6) See more
    Orthologs
    human all
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    Genomic context

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    See Lcn9 in Genome Data Viewer
    Location:
    2 A3; 2 18.15 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (25713100..25715558)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25823088..25825546)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 13539 Neighboring gene glycosyltransferase 6 domain containing 1 Neighboring gene predicted gene, 35689 Neighboring gene spermatogenesis and oogenesis specific basic helix-loop-helix 1 Neighboring gene STARR-seq mESC enhancer starr_03968 Neighboring gene potassium channel, subfamily T, member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Transcriptome profiling of the initial segment and proximal caput of mouse epididymis. Wang X, et al. Front Endocrinol (Lausanne), 2023. PMID 37324270, Free PMC Article
    2. Deficiency for Lcn8 causes epididymal sperm maturation defects in mice. Wen Z, et al. Biochem Biophys Res Commun, 2021 Apr 9. PMID 33631677
    3. CRISPR/Cas9-mediated disruption of lipocalins, Ly6g5b, and Ly6g5c causes male subfertility in mice. Sakurai N, et al. Andrology, 2024 Jul. PMID 36428102, Free PMC Article
    4. A novel mouse line with epididymal initial segment-specific expression of Cre recombinase driven by the endogenous Lcn9 promoter. Gong QQ, et al. PLoS One, 2021. PMID 34310634, Free PMC Article
    5. Molecular evolution of epididymal lipocalin genes localized on mouse chromosome 2. Suzuki K, et al. Gene, 2004 Sep 15. PMID 15363845

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A novel mouse line with epididymal initial segment-specific expression of Cre recombinase driven by the endogenous Lcn9 promoter.
      Title: A novel mouse line with epididymal initial segment-specific expression of Cre recombinase driven by the endogenous Lcn9 promoter.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5)  1 citation
    • Targeted (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables small molecule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    epididymal-specific lipocalin-9
    Names
    MUP-like lipocalin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029959.2 → NP_084235.1  epididymal-specific lipocalin-9 precursor

      See identical proteins and their annotated locations for NP_084235.1

      Status: VALIDATED

      Source sequence(s)
      AK020305
      Consensus CDS
      CCDS15792.1
      UniProtKB/Swiss-Prot
      Q80ZC4, Q9D267
      Related
      ENSMUSP00000023978.3, ENSMUST00000023978.3
      Conserved Domains (1) summary
      pfam00061
      Location:34 → 174
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      25713100..25715558
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319341.2 → XP_017174830.1  epididymal-specific lipocalin-9 isoform X4

      Conserved Domains (1) summary
      cl10502
      Location:2 → 142
      lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

    2. XM_017319340.2 → XP_017174829.1  epididymal-specific lipocalin-9 isoform X3

      Conserved Domains (1) summary
      cd19429
      Location:21 → 173
      lipocalin_9; lipocalin 9

    3. XM_017319338.1 → XP_017174827.1  epididymal-specific lipocalin-9 isoform X1

      Conserved Domains (1) summary
      cd19429
      Location:69 → 210
      lipocalin_9; lipocalin 9

    4. XM_017319339.1 → XP_017174828.1  epididymal-specific lipocalin-9 isoform X2

      Conserved Domains (1) summary
      cd19429
      Location:69 → 213
      lipocalin_9; lipocalin 9
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D267.1 GenPept UniProtKB/Swiss-Prot:Q9D267

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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