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    Sirt5 sirtuin 5 [ Mus musculus (house mouse) ]

    Gene ID: 68346, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sirt5provided by MGI
    Official Full Name
    sirtuin 5provided by MGI
    Primary source
    MGI:MGI:1915596
    See related
    Ensembl:ENSMUSG00000054021 AllianceGenome:MGI:1915596
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    0610012J09Rik; 1500032M05Rik
    Summary
    Enables protein-glutaryllysine deglutarylase activity; protein-malonyllysine demalonylase activity; and protein-succinyllysine desuccinylase activity. Involved in protein deacylation and regulation of ketone biosynthetic process. Acts upstream of or within regulation of succinate dehydrogenase activity and response to ischemia. Located in cytosol and mitochondrial inner membrane. Is expressed in several structures, including 1st branchial arch maxillary component; heart; oocyte; palatal shelf; and sensory organ. Orthologous to human SIRT5 (sirtuin 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 3.8), bladder adult (RPKM 2.9) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Sirt5 in Genome Data Viewer
    Location:
    13 A4; 13 21.6 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (43518849..43549073)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (43365389..43395203)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52047 Neighboring gene predicted gene, 53796 Neighboring gene RAN binding protein 9 Neighboring gene nucleolar protein 7 Neighboring gene predicted gene, 26064

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD+ binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables NAD+ binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables NAD+ binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables NAD-dependent protein lysine deacetylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone deacetylase activity, NAD-dependent IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-glutaryllysine deglutarylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-glutaryllysine deglutarylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein-glutaryllysine deglutarylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-malonyllysine demalonylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-malonyllysine demalonylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein-malonyllysine demalonylase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein-malonyllysine demalonylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-succinyllysine desuccinylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-succinyllysine desuccinylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein-succinyllysine desuccinylase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein-succinyllysine desuccinylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in negative regulation of cardiac muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-lysine demalonylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-lysine demalonylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within peptidyl-lysine desuccinylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-lysine desuccinylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-lysine desuccinylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein deacetylation ISO
    Inferred from Sequence Orthology
    more info
     
    NOT involved_in protein deacetylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein deglutarylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein deglutarylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein demalonylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein demalonylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein desuccinylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein desuccinylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein desuccinylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of ketone biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of succinate dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to ischemia IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial intermembrane space ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    NAD-dependent protein deacylase sirtuin-5, mitochondrial
    Names
    NAD-dependent deacetylase sirtuin-5
    NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial
    NP_849179.1
    XP_006517014.1
    XP_006517015.1
    XP_006517016.1
    XP_006517017.1
    XP_011242714.1
    XP_011242715.1
    XP_030103247.1
    XP_030103248.1
    XP_030103249.1
    XP_030103250.1
    XP_036014035.1
    XP_036014036.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178848.3NP_849179.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial

      See identical proteins and their annotated locations for NP_849179.1

      Status: PROVISIONAL

      Source sequence(s)
      AC132121
      Consensus CDS
      CCDS26478.1
      UniProtKB/Swiss-Prot
      Q8K2C6
      UniProtKB/TrEMBL
      A0A1Y7VJY8
      Related
      ENSMUSP00000152796.2, ENSMUST00000223194.2
      Conserved Domains (1) summary
      cd01412
      Location:51301
      SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      43518849..43549073
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516951.3XP_006517014.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006517014.1

      UniProtKB/TrEMBL
      A0A1Y7VJY8, A0A1Y7VM56
      Conserved Domains (1) summary
      cd01412
      Location:51289
      SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...
    2. XM_006516954.2XP_006517017.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X3

      Conserved Domains (1) summary
      cl00195
      Location:4181
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
    3. XM_036158143.1XP_036014036.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X4

      Conserved Domains (1) summary
      cl00195
      Location:4179
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
    4. XM_030247387.2XP_030103247.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X2

      UniProtKB/Swiss-Prot
      Q8K2C6
      UniProtKB/TrEMBL
      A0A1Y7VJY8
      Related
      ENSMUSP00000152740.2, ENSMUST00000220576.2
      Conserved Domains (1) summary
      cd01412
      Location:51301
      SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...
    5. XM_036158142.1XP_036014035.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X3

      Conserved Domains (1) summary
      cl00195
      Location:4181
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
    6. XM_006516953.3XP_006517016.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006517016.1

      UniProtKB/TrEMBL
      A0A1Y7VJY8, A0A1Y7VM56
      Related
      ENSMUSP00000152526.2, ENSMUST00000221515.2
      Conserved Domains (1) summary
      cd01412
      Location:51289
      SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...
    7. XM_006516952.5XP_006517015.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006517015.1

      UniProtKB/TrEMBL
      A0A1Y7VJY8, A0A1Y7VM56
      Conserved Domains (1) summary
      cd01412
      Location:51289
      SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...
    8. XM_030247390.2XP_030103250.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X4

      Conserved Domains (1) summary
      cl00195
      Location:4179
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
    9. XM_030247388.2XP_030103248.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X2

      UniProtKB/Swiss-Prot
      Q8K2C6
      UniProtKB/TrEMBL
      A0A1Y7VJY8
      Conserved Domains (1) summary
      cd01412
      Location:51301
      SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...
    10. XM_011244413.3XP_011242715.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_011242715.1

      UniProtKB/TrEMBL
      A0A1Y7VJY8, A0A1Y7VM56
      Conserved Domains (1) summary
      cd01412
      Location:51289
      SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...
    11. XM_030247389.2XP_030103249.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X2

      UniProtKB/Swiss-Prot
      Q8K2C6
      UniProtKB/TrEMBL
      A0A1Y7VJY8
      Conserved Domains (1) summary
      cd01412
      Location:51301
      SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...
    12. XM_011244412.3XP_011242714.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_011242714.1

      UniProtKB/TrEMBL
      A0A1Y7VJY8, A0A1Y7VM56
      Conserved Domains (1) summary
      cd01412
      Location:51289
      SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...