Ribc2 RIB43A domain with coiled-coils 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ribc2provided by MGI
Official Full Name: RIB43A domain with coiled-coils 2provided by MGI
Primary source: MGI:MGI:1914997
See related: Ensembl:ENSMUSG00000022431 AllianceGenome:MGI:1914997
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Trib; 4930579A10Rik
Summary: Involved in flagellated sperm motility. Is active in axonemal A tubule inner sheath and sperm flagellum. Is expressed in bladder wall; diaphragm; ilio-psoas; skeleton; and tail mesenchyme. Orthologous to human RIBC2 (RIB43A domain with coiled-coils 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis adult (RPKM 6.1) and bladder adult (RPKM 0.1) See more
Orthologs: human all
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Genomic context

Location:: 15 E2; 15 40.25 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (85016261..85028771)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (85132060..85144570)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genomic structure and expression profile of mouse Trib and comparison of its homology with other ribbon proteins.
Title: Genomic structure and expression analysis of the mouse testis-specific ribbon protein (Trib) gene.
Trib expression is testis-specific and appears to be found only in the germ cells during the leptotene-pachytene stages of spermatogenesis.
Title: Genomic structure and expression analysis of the mouse testis-specific ribbon protein (Trib) gene.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in flagellated sperm motility	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in axonemal A tubule inner sheath	IDA Inferred from Direct Assay more info	PubMed
located_in axonemal microtubule	ISO Inferred from Sequence Orthology more info
located_in axonemal microtubule	ISS Inferred from Sequence or Structural Similarity more info
is_active_in sperm flagellum	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: RIB43A-like with coiled-coils protein 2

Names: testis-specific ribbon protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026357.2 → NP_080633.2 RIB43A-like with coiled-coils protein 2

See identical proteins and their annotated locations for NP_080633.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the protein coding variant.

Source sequence(s)

AK016311, BY716712

Consensus CDS

CCDS49689.1

UniProtKB/Swiss-Prot

G3X8W0, Q9D4Q1

Related

ENSMUSP00000023067.3, ENSMUST00000023067.4

Conserved Domains (1) summary

pfam05914
Location:3 → 377

RIB43A

RNA

NR_152195.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AL772308

Related

ENSMUST00000229238.2
NR_164346.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL772308

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

85016261..85028771

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159551.1 → XP_036015444.1 RIB43A-like with coiled-coils protein 2 isoform X1

Conserved Domains (1) summary

pfam05914
Location:6 → 204

RIB43A
XM_036159552.1 → XP_036015445.1 RIB43A-like with coiled-coils protein 2 isoform X1

Conserved Domains (1) summary

pfam05914
Location:6 → 204

RIB43A
XM_036159553.1 → XP_036015446.1 RIB43A-like with coiled-coils protein 2 isoform X1

Conserved Domains (1) summary

pfam05914
Location:6 → 204

RIB43A