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    C1qtnf7 C1q and tumor necrosis factor related protein 7 [ Mus musculus (house mouse) ]

    Gene ID: 109323, updated on 27-Nov-2024

    Summary

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    Official Symbol
    C1qtnf7provided by MGI
    Official Full Name
    C1q and tumor necrosis factor related protein 7provided by MGI
    Primary source
    MGI:MGI:1925911
    See related
    Ensembl:ENSMUSG00000061535 AllianceGenome:MGI:1925911
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Adig; Ctrp7; 5530401N20Rik; 8430425G24Rik
    Summary
    Enables identical protein binding activity. Located in extracellular space. Is expressed in several structures, including adipose tissue; central nervous system; genitourinary system; gut; and skeleton. Orthologous to human C1QTNF7 (C1q and TNF related 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in bladder adult (RPKM 5.7), lung adult (RPKM 3.9) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See C1qtnf7 in Genome Data Viewer
    Location:
    5 B3; 5 23.78 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (43672792..43776805)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (43515425..43619126)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene 7854 Neighboring gene STARR-seq mESC enhancer starr_12968 Neighboring gene cytoplasmic polyadenylation element binding protein 2 Neighboring gene STARR-seq mESC enhancer starr_12969 Neighboring gene STARR-positive B cell enhancer mm9_chr5:43715638-43715939 Neighboring gene STARR-seq mESC enhancer starr_12970 Neighboring gene predicted gene 43699 Neighboring gene STARR-seq mESC enhancer starr_12971 Neighboring gene STARR-seq mESC enhancer starr_12973 Neighboring gene predicted gene 15866 Neighboring gene predicted gene, 35762 Neighboring gene coiled-coil and C2 domain containing 2A Neighboring gene F-box and leucine-rich repeat protein 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CTRP7 deletion attenuates obesity-linked glucose intolerance, adipose tissue inflammation, and hepatic stress. Petersen PS, et al. Am J Physiol Endocrinol Metab, 2017 Apr 1. PMID 28223291, Free PMC Article
    2. Expression of adipokines in preimplantation rabbit and mice embryos. Schmidt T, et al. Histochem Cell Biol, 2008 Jun. PMID 18330590
    3. A family of Acrp30/adiponectin structural and functional paralogs. Wong GW, et al. Proc Natl Acad Sci U S A, 2004 Jul 13. PMID 15231994, Free PMC Article
    4. Molecular, biochemical and functional characterizations of C1q/TNF family members: adipose-tissue-selective expression patterns, regulation by PPAR-gamma agonist, cysteine-mediated oligomerizations, combinatorial associations and metabolic functions. Wong GW, et al. Biochem J, 2008 Dec 1. PMID 18783346, Free PMC Article
    5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of collagen trimer IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    complement C1q tumor necrosis factor-related protein 7
    Names
    C1q and tumor necrosis factor related protein 5
    adiponectin g

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135172.1 → NP_001128644.1  complement C1q tumor necrosis factor-related protein 7 isoform a precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK017441, BC038308, BC090967
      Consensus CDS
      CCDS51488.1
      UniProtKB/TrEMBL
      A0A3B0J1T4, E9PVG1
      Related
      ENSMUSP00000076206.8, ENSMUST00000076939.10
      Conserved Domains (2) summary
      pfam01391
      Location:63 → 115
      Collagen; Collagen triple helix repeat (20 copies)
      pfam00386
      Location:156 → 280
      C1q; C1q domain

    2. NM_175425.4 → NP_780634.2  complement C1q tumor necrosis factor-related protein 7 isoform b precursor

      See identical proteins and their annotated locations for NP_780634.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses a downstream translation initiation codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      BC038308, BC090967
      Consensus CDS
      CCDS19262.1
      UniProtKB/Swiss-Prot
      Q8BVD7, Q8CHX9
      UniProtKB/TrEMBL
      A0A3B0J1T4, Q5BKS0
      Related
      ENSMUSP00000113520.2, ENSMUST00000121872.3
      Conserved Domains (2) summary
      pfam01391
      Location:56 → 108
      Collagen; Collagen triple helix repeat (20 copies)
      pfam00386
      Location:149 → 273
      C1q; C1q domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      43672792..43776805
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503665.5 → XP_006503728.1  complement C1q tumor necrosis factor-related protein 7 isoform X1

      See identical proteins and their annotated locations for XP_006503728.1

      UniProtKB/Swiss-Prot
      Q8BVD7, Q8CHX9
      UniProtKB/TrEMBL
      A0A3B0J1T4, Q5BKS0
      Conserved Domains (2) summary
      pfam01391
      Location:56 → 108
      Collagen; Collagen triple helix repeat (20 copies)
      pfam00386
      Location:149 → 273
      C1q; C1q domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BVD7.2 GenPept UniProtKB/Swiss-Prot:Q8BVD7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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